Fusidic Acid
- CAS No.
- 6990-06-3
- Chemical Name:
- Fusidic Acid
- Synonyms
- FUSIDIC ACID;Fusidine;Fusidinic acid;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;Fusidic acid CRS;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;sq16603;ramycin;Fuzidin
- CBNumber:
- CB8431174
- Molecular Formula:
- C31H48O6
- Molecular Weight:
- 516.71
- MDL Number:
- MFCD00865135
- MOL File:
- 6990-06-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fusidic acid European Pharmacopoeia (EP) Reference Standard | Y0001411 | 15 mg | $241 |
| Fusidic acid for peak identification European Pharmacopoeia (EP) Reference Standard | Y0001394 | 15 mg | $167 |
| Fusidic acid certified reference material, pharmaceutical secondary standard | PHR2810 | 50MG | $400 |
| Fusidic acid European Pharmacopoeia (EP) Reference Standard | Y0001411 | 10 mg | $225 |
| Fusidic acid European Pharmacopoeia (EP) Reference Standard | Y0001411 | y0001411 | $220 |
| More product size | |||
| Melting point | 190-192°C |
|---|---|
| alpha | D20 -9° (chloroform) |
| Boiling point | 521.49°C (rough estimate) |
| Density | 1.0389 (rough estimate) |
| vapor pressure | 0-0Pa at 25℃ |
| refractive index | 1.4890 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent) |
| pka | pK: 5.35 in water |
| form | Solid |
| color | White to Off-White |
| optical activity | -920 (c 1, CHCl3) |
| Water Solubility | 2.376-525000μg/L at 25℃ |
| λmax | 204nm(H2O)(lit.) |
| Merck | 14,4317 |
| Stability | Hygroscopic |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | IECPWNUMDGFDKC-MZJAQBGESA-N |
| SMILES | [H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C |
| LogP | 2.68-6.75 at 20℃ |
| CAS DataBase Reference | 6990-06-3(CAS DataBase Reference) |
| FDA UNII | 59XE10C19C |
| ATC code | D06AX01,D09AA02,J01XC01,S01AA13 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | RC1350000 |
| HS Code | 29419000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen) |
| REACH Registrations | Active |
Fusidic Acid price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001411 | Fusidic acid European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | 15 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001394 | Fusidic acid for peak identification European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | 15 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2810 | Fusidic acid certified reference material, pharmaceutical secondary standard | 6990-06-3 | 50MG | $400 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001411 | Fusidic acid European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | 10 mg | $225 | 2025-07-31 | Buy |
| Sigma-Aldrich | Y0001411 | Fusidic acid European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | y0001411 | $220 | 2024-03-01 | Buy |
Fusidic Acid Chemical Properties,Uses,Production
Mode of action
Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.
Structure
Fusidic acid is a 3alpha-hydroxy steroid, an 11alpha-hydroxy steroid, a sterol ester, a steroid acid, an alpha,beta-unsaturated monocarboxylic acid and a steroid antibiotic. It is a conjugate acid of a fusidate. Fusidic acid has an asteroid-type structure, as do some other antibiotics produced by fungi, but does not possess any steroid activity. The structure is thought to be responsible for the steroid-like high penetration.
Description
Fusidic Acid: An Inhibitor of the Elongation Factor G (EF-G)
Fusidic acid is a steroidal antibiotic compound derived from the fungus Fusidium coccineum. The elongation factor G (EF-G) catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Fusidic acid binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. Fusidic acid is mainly notable for its activity against staphylococci, whether or not they are resistant to methicillin and related penicillins. Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid structure but shows no hormonal activity.
Chemical Properties
White Solid
Uses
Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.
Uses
antibacterial
Definition
ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
brand name
Fucidine (Bristol-Myers Squibb).
Hazard
Moderately toxic inhibitor of translocation during protein synthesis.
Biological Activity
Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.
Biochem/physiol Actions
Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.
Fusidic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | tongyibiochem@163.com | China | 2995 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 906 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
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View Lastest Price from Fusidic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Fusidine
6990-06-3
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-06-08 | Fusidic acid
6990-06-3
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2026-06-03 | Fusidic Acid
6990-06-3
|
2Kg/Bag | 97.5% up / EP | 20 tons | Sinoway Industrial co., ltd. |
-
- Fusidine
6990-06-3
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Fusidic acid
6990-06-3
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- Fusidic Acid
6990-06-3
- $0.00
- 97.5% up / EP
- Sinoway Industrial co., ltd.
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