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Boc-1-amino-3,6-dioxa-8-octanediamine

Boc-1-amino-3,6-dioxa-8-octanediamine structure

CAS No.: 153086-78-3

Chemical Name:: Boc-1-amino-3,6-dioxa-8-octanediamine

Synonyms: BOC-NH-PEG2-NH2;NHBoc-PEG3-NH2;N-Boc-3,6-dioxaoctane-1,8-diamine;N-BOC-2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;{2-[2-(2-AMino-ethoxy)-ethoxy]-ethyl}-carbaMic acid tert-butyl ester;BOC-DOOA;NH2-PEG2-NHBOC;NHBoc-PEG2-amine;PROTAC Linker 13;BOC-N-AMIDO-PEG2-NH2

CBNumber:: CB8456887

Molecular Formula:: C11H24N2O4

Molecular Weight:: 248.32

MDL Number:: MFCD03788155

MOL File:: 153086-78-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:21:01

Product description	Number	Pack Size	Price
N-Boc- 2,2′-(ethylenedioxy)diethylamine ≥95.0% (NT)	89761	1g	$242
N-Boc- 2,2′-(ethylenedioxy)diethylamine ≥95.0% (NT)	89761	5G	$931
N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine >97.0%(HPLC)(T)	B5141	200mg	$55
N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine >97.0%(HPLC)	B5141	1g	$148
t-Boc-N-amido-PEG2-amine (Boc-1-amino-3,6-dioxa-8-octanediamine) ≥95%	516936	25g	$1111
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Boc-1-amino-3,6-dioxa-8-octanediamine Properties

Boiling point	365.2±27.0 °C(Predicted)
Density	1.046 g/mL at 20 °C
refractive index	1.4570 to 1.4610
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	12.23±0.46(Predicted)
form	clear liquid
color	Colorless to Light yellow to Light orange
InChI	InChI=1S/C11H24N2O4/c1-11(2,3)17-10(14)13-5-7-16-9-8-15-6-4-12/h4-9,12H2,1-3H3,(H,13,14)
InChIKey	OCUICOFGFQENAS-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCCOCCOCCN
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves
Risk Statements	36/37/38
Safety Statements	26-37/39
RIDADR	2735
WGK Germany	3
F	10-21
HazardClass	8
PackingGroup	Ⅲ
HS Code	29241990
Storage Class	10 - Combustible liquids

Boc-1-amino-3,6-dioxa-8-octanediamine price More Price(108)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	89761	N-Boc- 2,2′-(ethylenedioxy)diethylamine ≥95.0% (NT)	153086-78-3	1g	$242	2026-04-30	Buy
Sigma-Aldrich	89761	N-Boc- 2,2′-(ethylenedioxy)diethylamine ≥95.0% (NT)	153086-78-3	5G	$931	2026-04-30	Buy
TCI Chemical	B5141	N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine >97.0%(HPLC)(T)	153086-78-3	200mg	$55	2026-04-30	Buy
TCI Chemical	B5141	N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine >97.0%(HPLC)	153086-78-3	1g	$148	2026-04-30	Buy
Usbiological	516936	t-Boc-N-amido-PEG2-amine (Boc-1-amino-3,6-dioxa-8-octanediamine) ≥95%	153086-78-3	25g	$1111	2026-06-03	Buy

Product number	Packaging	Price	Buy
89761	1g	$242	Buy
89761	5G	$931	Buy
B5141	200mg	$55	Buy
B5141	1g	$148	Buy
516936	25g	$1111	Buy

Boc-1-amino-3,6-dioxa-8-octanediamine Chemical Properties,Uses,Production

Description

t-Boc-N-Amido-PEG2-amine is a PEG linker containing an amino group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Light yellow oil

Uses

Linker reagent for the prep. of a broad variety of linked tags, monomers for polymerisation, ionophores etc., e.g. biotinylation reagents.

reaction suitability

reagent type: cross-linking reagent

Synthesis

929-59-9

24424-99-5

153086-78-3

General procedure: A dichloromethane solution (10 mL/mmol) of 1,8-diamino-3,6-dioxaoctane (1 eq.) was treated with di-tert-butyl dicarbonate (0.15 eq.) at 0 °C, kept at 0 °C for 5 hours, and then the reaction was continued at room temperature for 18 hours. Upon completion of the reaction, the organic phase was washed with water until all unreacted 1,8-diamino-3,6-dioxaoctane was removed by extraction. The organic phase was dried over anhydrous magnesium sulfate and recovered quantitatively to give the Boc-protected product tert-butyl 2-(2-(2-aminoethoxy)ethoxy)ethylcarbamate, which was concentrated under vacuum. The product characterization data were as follows:11a: 1H NMR (300 MHz, CDCl3): δ 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2).11b: 1H NMR ( 300 MHz, CDCl3): δ 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2).

IC 50

PEGs

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4208 - 4212
[2] Tetrahedron, 2012, vol. 68, # 52, p. 10818 - 10826
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2678 - 2685
[4] Journal of the American Chemical Society, 2013, vol. 135, # 34, p. 12684 - 12689
[5] Tetrahedron, 2017, vol. 73, # 33, p. 4972 - 4978

Boc-1-amino-3,6-dioxa-8-octanediamine synthesis

Synthesis of Boc-1-amino-3,6-dioxa-8-octanediamine from 1,8-Diamino-3,6-dioxaoctane and Di-tert-butyl dicarbonate

Boc-1-amino-3,6-dioxa-8-octanediamine Preparation Products And Raw materials

Raw materials

Acetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2,2,2-trifluoro- Boc-NH-PEG2-NH-Boc 1,8-Diazido-3,5-dioxaoctane t-Boc-N-Amido-PEG2-Azide Carbonochloridic acid, 1,1-diMethylethyl ester

1,8-Diamino-3,6-dioxaoctane Di-tert-butyl dicarbonate

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Preparation Products

2-[2-(2-Azidoethoxy)ethoxy]ethanamine

Boc-1-amino-3,6-dioxa-8-octanediamine Suppliers

Global( 262)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	489	58
Adachibio Inc.	+81-8027837258; +8108027837258	sales@adachibio.com	Japan	938	58
LAURENT	+8618100176782	sun@laurentpeg.com	China	365	58
9i LLC	+18039569191	MWan@NiNeiLab.com	United States	418	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Suzhou Highfine Biotech Co.,Ltd.	58
Adachibio Inc.	58
LAURENT	58
9i LLC	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Shandong chuangyingchemical Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Boc-1-amino-3,6-dioxa-8-octanediamine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-08	tert-Butyl [2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate 153086-78-3	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.
2026-05-11	Boc-NH-PEG2-C2-NH2 153086-78-3			10g	TargetMol Chemicals Inc.
2026-02-05	tert-butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate 153086-78-3	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.

tert-Butyl [2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate
153086-78-3
99%
Jinan Ruitong Biotech Co., Ltd.

Boc-NH-PEG2-C2-NH2
153086-78-3
$0.00
TargetMol Chemicals Inc.

tert-butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate
153086-78-3
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Boc-1-amino-3,6-dioxa-8-octanediamine Spectrum

Boc-1-amino-3,6-dioxa-8-octanediamine(153086-78-3)¹HNMR

153086-78-3(Boc-1-amino-3,6-dioxa-8-octanediamine)Related Search:

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TERT-BUTYL 2-[2-(2-AMINOETHOXY)ETHOXY]ETHYLCARBAMATE N-BOC-3,6-DIOXA-1,8-OCTANEDIAMINE 1-(TERT-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE, LIQ. 1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE, LIQ. 5,8-dioxa-2-azadiheptaoic acid, 10-aMino-,1,1-diMethylethyl ester Boc-NH-PEG2-CH2CH2NH2 N-Boc- 2,2'-(ethylenedioxy)diethylaMine >=95.0% (NT) CarbaMic acid,N-[2-[2-(2-aMinoethoxy)ethoxy]ethyl]-, 1,1-diMethylethyl ester t-Boc-N-amido-PEG2-Amine N-Boc- 2,2′-(ethylenedioxy)diethylamine, >=98% N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine Boc-N-amido-PEG2-Amine Boc-NH-PEG3 Boc-1-amino-3,6-dioxa-8-octanediamine tert-Butyl (2-(2-(2-aminoethoxy) N-Boc-2-[2-(2-amino-ethoxy)-ethoxy]-ethylamine Boc-1-amino-3,6-dioxa-8-octanediamine≥ 97% (Titration) BOC-N-AMIDO-PEG2-NH2 BOC-1-AMINO-3,6-DIOXA-8-OCTANEDIAMINE BOC-DOOA 1-(TERT-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE 1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAMINE t-Boc-N-amido-PEG2-Amine 98% NHBoc-PEG2-amine PROTAC Linker 13 Boc-N-amido-PEG2-Amine,t-boc-N-amido-PEG2-amine N-tert-Butyloxycarbonyl-1,8-diamino-3,6-dioxaoctane N-(tert-Butoxycarbonyl)-3,6-dioxa-1,8-octanediamine N-Boc-2-[2-(2-amino-ethoxy)-etho tert-butyl N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate Boc-1-amino-3,6-dioxa-8-octanediamine(Boc-NH-PEG3) t-BocNH-PEG2-CH2CH2NH2 N-BOC-2,2'-(ETHYLENEDIOXY)DIETHYLAMINE {2-[2-(2-AMino-ethoxy)-ethoxy]-ethyl}-carbaMic acid tert-butyl ester NHBoc-PEG3-NH2 t-Boc-Amido-PEG3-Amine NH2-PEG2-NHBOC Boc-N-amido-PEG2-Amine t-boc-N-amido-PEG2-amin N-BOC-2,2′-(ethylenedioxy)bis(ethylamine) N-Boc-2,2’-(ethylenedioxy)diethylamine N-Boc- 2,2′-(ethylenedioxy)diethylamine BOC-NH-PEG2-NH2 N-Boc-3,6-dioxaoctane-1,8-diamine 153086-78-3 153086-78-8 C11H24N2O4 Bifunctional Crosslinkers Specialty Synthesis Peptide Synthesis Linkers peg

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