Glycoluril
- CAS No.
- 496-46-8
- Chemical Name:
- Glycoluril
- Synonyms
- Acetylene carbamide;TETRAHYDROIMIDAZO[4,5-D]IMIDAZOLE-2,5(1H,3H)-DIONE;5(1H;NSC 2765;Glycouril;Glycolueil;Glycoluril;Gansu urea;Glyoxalbiuret;ACETYLENEUREA
- CBNumber:
- CB8461401
- Molecular Formula:
- C4H6N4O2
- Molecular Weight:
- 142.12
- MDL Number:
- MFCD00005539
- MOL File:
- 496-46-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Glycoluril 97% | G7305 | 5g | $48 |
| Glycoluril 97% | G7305 | 100g | $157 |
| Glycoluril >98.0%(N) | G0243 | 25g | $53 |
| Glycouril | FG03387 | 1kg | $226.76 |
| Glycouril | FG03387 | 2kg | $362.82 |
| More product size | |||
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 259.66°C (rough estimate) |
| Density | 1.4926 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.8500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 15g/l |
| pka | 12.91±0.20(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | 1.8g/L at 20℃ |
| Merck | 14,93 |
| BRN | 128826 |
| InChI | 1S/C4H6N4O2/c9-3-5-1-2(7-3)8-4(10)6-1/h1-2H,(H2,5,7,9)(H2,6,8,10) |
| InChIKey | VPVSTMAPERLKKM-UHFFFAOYSA-N |
| SMILES | O=C1NC2NC(=O)NC2N1 |
| LogP | -3.28 |
| CAS DataBase Reference | 496-46-8(CAS DataBase Reference) |
| FDA UNII | U9H2W4OS13 |
| NIST Chemistry Reference | Glycoluril(496-46-8) |
| EPA Substance Registry System | Glycoluril (496-46-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29332990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Glycoluril price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G7305 | Glycoluril 97% | 496-46-8 | 5g | $48 | 2026-04-30 | Buy |
| Sigma-Aldrich | G7305 | Glycoluril 97% | 496-46-8 | 100g | $157 | 2026-04-30 | Buy |
| TCI Chemical | G0243 | Glycoluril >98.0%(N) | 496-46-8 | 25g | $53 | 2026-04-30 | Buy |
| Biosynth | FG03387 | Glycouril | 496-46-8 | 1kg | $226.76 | 2026-06-04 | Buy |
| Biosynth | FG03387 | Glycouril | 496-46-8 | 2kg | $362.82 | 2026-06-04 | Buy |
Glycoluril Chemical Properties,Uses,Production
Chemical Properties
WHITE TO VERY SLIGHTLY YELLOW CRYSTALLINE POWDER
Uses
Reactant involved in synthesis of:• ;Glycouril hexamers and monofunctionalized cucurbit[6]uril derivatives1,2,3• ;N-chloro compounds from trichloroisocyanuric acid4• ;Glycouril trimers5
Uses
Glycoluril is used as a reagent in the synthesis of acyclic cucurbit[n]uril molecular containers which can enhance the solubility and bioactivity of poorly soluble pharmaceuticals. Also used as a reagent in the synthesis of cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells.
Uses
For derivatives glycoluril, glycoluril resins
Definition
ChEBI: Glycoluril is an azabicycloalkane and a member of ureas.
Flammability and Explosibility
Not classified
Agricultural Uses
Glycine is the simplest naturally occurring amino acid and is a constituent of most proteins. Its formula is H2N·CH2·COOH.
Synthesis
131543-46-9
57-13-6
496-46-8
To a 500 mL three-necked round-bottomed flask equipped with a stirrer was added 100 mL of deionized water, glyoxal (20 g, 0.345 mol, 1.00 eq., 50 mL of a 40 wt% aqueous solution) and urea (51.7 g, 0.862 mol, 2.50 eq.). The reaction mixture was heated to 90°C and stirred for 5 minutes. Concentrated sulfuric acid (4 mL) was slowly added dropwise over 5 minutes, and a white solid formed within 10 minutes after the drop was completed. Stirring of the reaction mixture was continued for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and 50% aqueous sodium hydroxide was added dropwise until the pH was adjusted to 14. Stirring was stopped and the reaction mixture was cooled to 0°C. The suspension was separated by vacuum filtration through a Brinell's funnel and the solids were washed with cold water (2 x 500 mL). The solid was transferred to a Brinell funnel and dried under suction for 3 h. Subsequently, it was transferred to a 700 mL beaker and dried at 80°C for 16 h. Glycuronium (1) was obtained as an off-white powder in 45.0 g (0.304 mol, 92% yield). Melting point: 335.19°C; IR (cm^-1): 3182.5 (s), 1677.0 (s); 1H NMR (90 MHz, DMSO-d6): δ 7.13 (s, 4H, -NH), 5.23 (s, 2H, N-CH-N).
References
[1] Tetrahedron Letters, 2016, vol. 57, # 15, p. 1681 - 1682
[2] Patent: WO2014/166347, 2014, A1. Location in patent: Page/Page column 13
[3] Patent: WO2015/143974, 2015, A1. Location in patent: Page/Page column 15
[4] J. Gen. Chem. USSR (Engl. Transl.), 1991, vol. 61, # 12, p. 2581 - 2582
[5] Zhurnal Obshchei Khimii, 1991, vol. 61, # 12, p. 2778 - 2780
Glycoluril Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Alfa Chemistry | -- | info@alfa-chemistry.com | United States | 2344 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9050 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from Glycoluril manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Glycoluril
496-46-8
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
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2025-04-04 | Glycoluril
496-46-8
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2021-07-13 | Glycoluril
496-46-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Glycoluril
496-46-8
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- Glycoluril
496-46-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Glycoluril
496-46-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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