5'-O-Tritylthymidine
- CAS No.
- 7791-71-1
- Chemical Name:
- 5'-O-Tritylthymidine
- Synonyms
- Trt-dT;5'-O-Trt-dT;5'-O-Tritylthymidine;5'-O-Tritylthymidine;5'-O-Trt-deoxythymidine;5'-Trt-2'-deoxythymidine;5''-O-TRITYLTHYMIDINE(5-OTT);5'-O-Triphenylmethylthymidine;5’-o-(triphenylmethyl)-thymidin;5'-o-(Triphenylmethyl)thymidine
- CBNumber:
- CB8667719
- Molecular Formula:
- C29H28N2O5
- Molecular Weight:
- 484.54
- MDL Number:
- MFCD00038462
- MOL File:
- 7791-71-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5'-O-Tritylthymidine Asreported | 296473 | 500mg | $453 |
| 5'-O-Tritylthymidine Asreported | 296473 | 1g | $616 |
| 5'-O-Tritylthymidine Asreported | 296473 | 2g | $945 |
| 5'-O-Tritylthymidine Asreported | 296473 | 5g | $1574 |
| 5'-O-Tritylthymidine Asreported | 296473 | 10g | $2464 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
5'-O-Tritylthymidine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 296473 | 5'-O-Tritylthymidine Asreported | 7791-71-1 | 500mg | $453 | 2026-06-03 | Buy |
| Usbiological | 296473 | 5'-O-Tritylthymidine Asreported | 7791-71-1 | 1g | $616 | 2026-06-03 | Buy |
| Usbiological | 296473 | 5'-O-Tritylthymidine Asreported | 7791-71-1 | 2g | $945 | 2026-06-03 | Buy |
| Usbiological | 296473 | 5'-O-Tritylthymidine Asreported | 7791-71-1 | 5g | $1574 | 2026-06-03 | Buy |
| Usbiological | 296473 | 5'-O-Tritylthymidine Asreported | 7791-71-1 | 10g | $2464 | 2026-06-03 | Buy |
5'-O-Tritylthymidine Chemical Properties,Uses,Production
Uses
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis[1]. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.
Synthesis
76-83-5
50-89-5
7791-71-1
Triphenylchloromethane (15 g, 53.7 mmol) was slowly added to a solution of pyridine (40 mL) containing 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2,4(1H,3H)-dione (10 g, 41.3 mmol) under nitrogen protection, and the reaction mixture was kept at room temperature for The reaction mixture was stirred for 21.5 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution to the system, followed by extraction and separation with dichloromethane. The organic phase was washed sequentially with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (eluent ratio of ethyl acetate:n-hexane=1:1) to afford the target compound 1-((2R,4S,5R)-4-hydroxy-5-((triphenylmethoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (19.4 g, 97.1% yield), as colorless acicular crystals. ), colorless needle-like crystals.
References
[1] Hernández A et al. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45(19):4254-63. DOI:10.1021/jm011128+
[2] Golubovskaya V et al. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13(4):532-45. DOI:10.2174/1871520611313040002
5'-O-Tritylthymidine Preparation Products And Raw materials
5'-O-Tritylthymidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9985 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055326116 | sales1@nuowei-chem.com | China | 1627 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
View Lastest Price from 5'-O-Tritylthymidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-28 | 5'-O-Tritylthymidine
7791-71-1
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-04-04 | 5'-O-Tritylthymidine
7791-71-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-12-24 | 5'-O-Tritylthymidine
7791-71-1
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 5'-O-Tritylthymidine
7791-71-1
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 5'-O-Tritylthymidine
7791-71-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5'-O-Tritylthymidine
7791-71-1
- $1.00
- 99%
- Career Henan Chemical Co
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