4-(TRIFLUOROMETHYL)PIPERIDINE
- CAS No.
- 657-36-3
- Chemical Name:
- 4-(TRIFLUOROMETHYL)PIPERIDINE
- Synonyms
- 4-TrifluorMethylpiperidine;4-(TRIFLUOROMETHYL)PIPERIDINE;4-TrifluoroMethylpiperidine HCI;Piperidine, 4-(trifluoromethyl)-;4-(Trifluoromethyl)piperidine 97%
- CBNumber:
- CB8670405
- Molecular Formula:
- C6H10F3N
- Molecular Weight:
- 153.15
- MDL Number:
- MFCD00102068
- MOL File:
- 657-36-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethyl)piperidine >97.0%(GC)(T) | T3081 | 1g | $96 |
| 4-(Trifluoromethyl)piperidine >97.0%(GC)(T) | T3081 | 5g | $289 |
| 4-(Trifluoromethyl)piperidine 98% | PC49502 | 1g | $26 |
| 4-(Trifluoromethyl)piperidine 98% | PC49502 | 5g | $62 |
| 4-(Trifluoromethyl)piperidine 98% | PC49502 | 25g | $281 |
| More product size | |||
| Melting point | 152-154°C |
|---|---|
| Boiling point | 126-129°C |
| Density | 1.129±0.06 g/cm3(Predicted) |
| refractive index | 1.3910 to 1.3950 |
| storage temp. | 2-8°C(protect from light) |
| form | Liquid |
| pka | 9.62±0.10(Predicted) |
| color | Colorless |
| InChI | InChI=1S/C6H10F3N/c7-6(8,9)5-1-3-10-4-2-5/h5,10H,1-4H2 |
| InChIKey | RDRQUUWCJTYHCT-UHFFFAOYSA-N |
| SMILES | N1CCC(C(F)(F)F)CC1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | N | |||||||||
| Risk Statements | 36/37/38-50 | |||||||||
| Safety Statements | 26-36/37/39-61 | |||||||||
| RIDADR | 2735 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-(TRIFLUOROMETHYL)PIPERIDINE price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3081 | 4-(Trifluoromethyl)piperidine >97.0%(GC)(T) | 657-36-3 | 1g | $96 | 2026-04-30 | Buy |
| TCI Chemical | T3081 | 4-(Trifluoromethyl)piperidine >97.0%(GC)(T) | 657-36-3 | 5g | $289 | 2026-04-30 | Buy |
| Apolloscientific | PC49502 | 4-(Trifluoromethyl)piperidine 98% | 657-36-3 | 1g | $26 | 2026-06-04 | Buy |
| Apolloscientific | PC49502 | 4-(Trifluoromethyl)piperidine 98% | 657-36-3 | 5g | $62 | 2026-06-04 | Buy |
| Apolloscientific | PC49502 | 4-(Trifluoromethyl)piperidine 98% | 657-36-3 | 25g | $281 | 2026-06-04 | Buy |
4-(TRIFLUOROMETHYL)PIPERIDINE Chemical Properties,Uses,Production
Uses
4-(Trifluoromethyl)piperidine is used in the preparation of retinoid-related orphan receptor inhibitors.
Synthesis
3796-24-5
657-36-3
GENERAL STEPS: An autoclave (Par 477) equipped with PID temperature control and kinetic measurement storage and a HEL 24 Cat reactor for substrate range testing were used as the reactor for the hydrogenation reaction. In standard experiments, the autoclave was placed in a glove box and the desired Rh NPs (1.25 or 0.625 mol%; catalyst concentration was calculated based on the total number of metallic Rh atoms on the NP surface) and the substrate (concentration of 0.124 M in THF) were added. Subsequently, molecular hydrogen was passed until the set pressure was reached and the reaction was stirred at the selected temperature for the desired time. Upon completion of the reaction, the autoclave was depressurized and the solution was filtered through silica gel for subsequent GC analysis. The conversion and selectivity of each reaction product was determined by GC-FID on an Agilent Technologies 7890A spectrometer using undecane as an internal standard on an HP-5 column (30 m × 0.25 mm × 0.25 μm).The TOF (conversion frequency) was defined as the number of moles of product generated per mole of Rh per hour on the NP surface.
References
[1] Journal of Catalysis, 2017, vol. 354, p. 113 - 127
4-(TRIFLUOROMETHYL)PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5746 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-(TRIFLUOROMETHYL)PIPERIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | 4-Trifluoromethyl-piperidine
657-36-3
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2026-06-30 | 4-(TRIFLUOROMETHYL)PIPERIDINE
657-36-3
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 4-(Trifluoromethyl)piperidine
657-36-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 4-Trifluoromethyl-piperidine
657-36-3
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-(TRIFLUOROMETHYL)PIPERIDINE
657-36-3
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(Trifluoromethyl)piperidine
657-36-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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