Moxonidine hydrochloride
- CAS No.
- 75438-58-3
- Chemical Name:
- Moxonidine hydrochloride
- Synonyms
- BDF-5895 HCL;MOXONIDINE HCL;Moxoidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;Moxonidine hydrochloride USP/EP/BP;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
- CBNumber:
- CB8686233
- Molecular Formula:
- C9H13Cl2N5O
- Molecular Weight:
- 278.14
- MDL Number:
- MFCD06795643
- MOL File:
- 75438-58-3.mol
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Moxonidine hydrochloride ≥98% | M1559 | 10MG | $135 |
| Moxonidine hydrochloride ≥98% | M1559 | 25MG | $267 |
| Moxonidine hydrochloride | ADA43858 | 250mg | $1090 |
| Moxonidine hydrochloride | ADA43858 | 500mg | $1515 |
| Moxonidine hydrochloride | 255893 | 10mg | $403 |
| More product size | |||
| Melting point | 189° |
|---|---|
| InChI | InChI=1S/C9H14ClN5O.ClH/c1-9(15-8-11-3-4-12-8)13-6(10)5-7(14-9)16-2;/h5,13H,3-4H2,1-2H3,(H2,11,12,15);1H |
| InChIKey | SKWXZGXGBKLLOD-UHFFFAOYSA-N |
| SMILES | C1(C)(NC2NCCN=2)N=C(OC)C=C(Cl)N1.[H]Cl |
| CAS DataBase Reference | 75438-58-3(CAS DataBase Reference) |
| FDA UNII | 5RYW07SK5E |
Moxonidine hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M1559 | Moxonidine hydrochloride ≥98% | 10MG | $135 | 2026-04-30 | Buy | |
| Sigma-Aldrich | M1559 | Moxonidine hydrochloride ≥98% | 25MG | $267 | 2026-04-30 | Buy | |
| Biosynth | ADA43858 | Moxonidine hydrochloride | 75438-58-3 | 250mg | $1090 | 2026-06-04 | Buy |
| Biosynth | ADA43858 | Moxonidine hydrochloride | 75438-58-3 | 500mg | $1515 | 2026-06-04 | Buy |
| Usbiological | 255893 | Moxonidine hydrochloride | 75438-58-3 | 10mg | $403 | 2021-12-16 | Buy |
Moxonidine hydrochloride Chemical Properties,Uses,Production
Description
Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Uses
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.
Application
Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN).
Biological Activity
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Moxonidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 | sales@synbestech.com | CHINA | 170 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15083 | 58 |
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 815 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5983 | 58 |
View Lastest Price from Moxonidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-18 | Moxonidine hydrochloride
75438-58-3
|
1KG | 97.5%-102% HPLC;EP | 10KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2020-05-10 | Moxonidine hydrochloride
75438-58-3
|
1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-01-13 | Moxonidine hydrochloride
75438-58-3
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Moxonidine hydrochloride
75438-58-3
- $0.00
- 97.5%-102% HPLC;EP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Moxonidine hydrochloride
75438-58-3
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Moxonidine hydrochloride
75438-58-3
- $9.80
- ≥98%
- Career Henan Chemical Co
