Vanillyl alcohol
- CAS No.
- 498-00-0
- Chemical Name:
- Vanillyl alcohol
- Synonyms
- 4-HYDROXY-3-METHOXYBENZYL ALCOHOL;Vanillin alcohol;FEMA 3737;vanillol;Vanillyl;Vanillinol;VANILLYL ALCOHOL(RG);4-HYDROXY-3-METHOXYBENZENEMETHANOL;4-Hydroxy-3-Methoxybenze-neMenthanol;4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL)
- CBNumber:
- CB8709532
- Molecular Formula:
- C8H10O3
- Molecular Weight:
- 154.16
- MDL Number:
- MFCD00004659
- MOL File:
- 498-00-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Vanillyl alcohol ≥98%, FG | W373702 | 1 each | $58 |
| Vanillyl alcohol ≥98%, FG | W373702 | 100g | $122 |
| Vanillyl alcohol ≥98%, FG | W373702 | 1kg | $409 |
| 4-Hydroxy-3-methoxybenzyl alcohol 98% | 175536 | 50g | $73.3 |
| 4-Hydroxy-3-methoxybenzyl alcohol 98% | 175536 | 250g | $158 |
| More product size | |||
| Melting point | 110-117 °C (lit.) |
|---|---|
| Boiling point | 237.52°C (rough estimate) |
| Density | 1.1690 (rough estimate) |
| refractive index | 1.4620 (estimate) |
| FEMA | 3737 | VANILLYL ALCOHOL |
| FLAVIS Number | 02.213 | Vanillyl alcohol |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | Fine Crystalline Powder |
| pka | 9.75±0.18(Predicted) |
| color | Off-white to beige |
| Odor | at 100.00 %. sweet creamy vanilla caramellic coconut graham cracker tonka milky powdery |
| Odor Type | creamy |
| biological source | synthetic |
| Water Solubility | Soluble in 95% ethanol (5 %), water, and oils. |
| JECFA Number | 886 |
| BRN | 1910044 |
| Henry's Law Constant | 9.6×104 mol/(m3Pa) at 25℃, McFall et al. (2020) |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| InChI | 1S/C8H10O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,9-10H,5H2,1H3 |
| InChIKey | ZENOXNGFMSCLLL-UHFFFAOYSA-N |
| SMILES | COc1cc(CO)ccc1O |
| LogP | 0.42 |
| Substances Added to Food (formerly EAFUS) | VANILLYL ALCOHOL |
| CAS DataBase Reference | 498-00-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | X7EA1JUA6M |
| NIST Chemistry Reference | 4-Hydroxy-3-methoxybenzyl alcohol(498-00-0) |
| UNSPSC Code | 12164502 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29095090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Vanillyl alcohol price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W373702 | Vanillyl alcohol ≥98%, FG | 498-00-0 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W373702 | Vanillyl alcohol ≥98%, FG | 498-00-0 | 100g | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | W373702 | Vanillyl alcohol ≥98%, FG | 498-00-0 | 1kg | $409 | 2026-04-30 | Buy |
| Sigma-Aldrich | 175536 | 4-Hydroxy-3-methoxybenzyl alcohol 98% | 498-00-0 | 50g | $73.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 175536 | 4-Hydroxy-3-methoxybenzyl alcohol 98% | 498-00-0 | 250g | $158 | 2026-04-30 | Buy |
Vanillyl alcohol Chemical Properties,Uses,Production
Description
4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.
Chemical Properties
Vanillyl alcohol is a lignin derived aromatic diol. It has a mild, sweet, balsamic, vanilla-like odor. It has a potential for the production of renewable epoxy thermosets. A bio-based bisphenolic analogue, bisguaiacol, was synthesized via the electrophilic aromatic condensation of vanillyl alcohol and guaiacol. From this, the diglycidyl ether of bisguaiacol was prepared. Further, three single aromatic diglycidyl ethers were synthesized from vanillyl alcohol, gastrodigenin, and hydroquinone.
Chemical Properties
crystalline white to off-white powder
Uses
Used as a flavoring agent. Other possible uses, vanilla, coconut, cream and other dairy nuances, coumarin.
Definition
ChEBI: Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols.
Taste threshold values
Sweet, creamy and milky with a slightly powdery mouthfeel.
General Description
Vanillyl alcohol belongs to the phenolic group of compounds which are widely used as oxidants in food products.
reaction suitability
reagent type: cross-linking reagent
Biochem/physiol Actions
Odor at 1.0%: sweet creamy, phenolic, vanilla and coconut-like with slight brown and coumarinic nuances.
Synthesis
Vanillyl alcohol is prepared from Vanillin by hydrogenation in presence of Platinum black.
References
Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.
Vanillyl alcohol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beri Pharma Co., Ltd. | +8613417710166 | sales@zhberi.com | China | 227 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3625 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhuyan (Hainan) Biotechnology Co., LTD | +8618163349544 | mollylucking@foxmail.com | China | 3000 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
View Lastest Price from Vanillyl alcohol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 4-Hydroxy-3-Methoxybenzyl Alcohol
498-00-0
|
$3.00 | 1KG | 99.% | 50 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-22 | Vanillyl alcohol
498-00-0
|
1G/KG | 99% | 10000000KG | Anhuyan (Hainan) Biotechnology Co., LTD | ||
 |
2026-05-22 | Vanillyl alcohol
498-00-0
|
99% | 2000000kg | Anhuyan (Hainan) Biotechnology Co., LTD |
-
- 4-Hydroxy-3-Methoxybenzyl Alcohol
498-00-0
- $3.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Vanillyl alcohol
498-00-0
- $0.00
- 99%
- Anhuyan (Hainan) Biotechnology Co., LTD
-
- Vanillyl alcohol
498-00-0
- 99%
- Anhuyan (Hainan) Biotechnology Co., LTD
