1-Benzyl-3-pyrrolidinone
- CAS No.
- 775-16-6
- Chemical Name:
- 1-Benzyl-3-pyrrolidinone
- Synonyms
- 1-BENZYLPYRROLIDIN-3-ONE;1-Benzylpyrrolidinone;N-BENZYL-3-PYRROLIDONE;1-BENZYL-3-PYRROLIDONE;1-BENZLY-3-PYRROLIDONE;5 N-Benzyl-3-Pyrrolidone;N-BeNzyl-3-pyrrolidiNoNe;1-BENZYL-3-PYRROLIDINONE;1-Benzyl-3-pyrrolizinone;1-Benzylpyrrolizin-3-one
- CBNumber:
- CB8753449
- Molecular Formula:
- C11H13NO
- Molecular Weight:
- 175.23
- MDL Number:
- MFCD00005342
- MOL File:
- 775-16-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Benzyl-3-pyrrolidone >98.0%(GC)(T) | B3606 | 5g | $128 |
| 1-Benzyl-3-pyrrolidone >98.0%(GC)(T) | B3606 | 25g | $292 |
| N-BENZYL-3-PYRROLIDINONE 95% | 53982 | 25G | $64 |
| 1-Benzylpyrrolidin-3-one ≥95% | OR301019 | 5g | $21 |
| 1-Benzylpyrrolidin-3-one ≥95% | OR301019 | 25g | $44 |
| More product size | |||
| Boiling point | 77 °C/0.01 mmHg (lit.) |
|---|---|
| Density | 1.091 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | 5.56±0.20(Predicted) |
| form | Crystalline Powder, Crystals or Chunks |
| color | White to off-white |
| BRN | 1526217 |
| InChI | InChI=1S/C11H13NO/c13-11-6-7-12(9-11)8-10-4-2-1-3-5-10/h1-5H,6-9H2 |
| InChIKey | DHGMDHQNUNRMIN-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=CC=C2)CCC(=O)C1 |
| CAS DataBase Reference | 775-16-6(CAS DataBase Reference) |
| FDA UNII | U4F247KXW3 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P280a-P321-P332+P313-P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-24/25-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-Benzyl-3-pyrrolidinone price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3606 | 1-Benzyl-3-pyrrolidone >98.0%(GC)(T) | 775-16-6 | 5g | $128 | 2023-01-07 | Buy |
| TCI Chemical | B3606 | 1-Benzyl-3-pyrrolidone >98.0%(GC)(T) | 775-16-6 | 25g | $292 | 2026-04-30 | Buy |
| AstaTech | 53982 | N-BENZYL-3-PYRROLIDINONE 95% | 775-16-6 | 25G | $64 | 2026-04-30 | Buy |
| Apolloscientific | OR301019 | 1-Benzylpyrrolidin-3-one ≥95% | 775-16-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR301019 | 1-Benzylpyrrolidin-3-one ≥95% | 775-16-6 | 25g | $44 | 2026-06-04 | Buy |
1-Benzyl-3-pyrrolidinone Chemical Properties,Uses,Production
Chemical Properties
clear yellow liquid
Uses
1-Benzyl-3-pyrrolidinone was used as starting reagent in the synthesis of vinyl triflate. It was used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.
Uses
Substrate used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.1
Uses
1-Benzyl-3-pyrrolidinone is a substrate used to prepare chiral, alkenyl sulfoximines leading to highly functionalized diazabicycles.
General Description
The equilibrium constant for the ketoreductase-catalyzed reduction reaction of 1-benzyl-3-pyrrolidinone has been measured in n-hexane. 1-Benzyl-3-pyrrolidinone on enzymatic asymmetric reduction yields enantiopure 1-benzyl-3-hydroxypyrrolidine, well known intermediate for various drugs.
Synthesis
775-15-5
775-16-6
General procedure for the synthesis of 1-benzyl-3-pyrrolidinone from N-benzyl-3-hydroxypyrrolidine: 12.50 g of oxalyl chloride was slowly added dropwise to 70 mL of dichloromethane, stirred and cooled to -65 °C or lower. Subsequently, a dichloromethane solution of 5.0 g of DMSO was added dropwise, keeping the reaction temperature at -65°C. After dropwise addition, stirring was continued for 30 minutes. Next, 8.80 g of a dichloromethane solution of 1-benzyl-3-hydroxypyrrolidine was added dropwise, maintaining the temperature at -65 °C, and the reaction progress was monitored by TLC. After 2 hours of reaction, triethylamine was slowly added dropwise at -65 °C, controlling the temperature at -65 °C, and stirring was continued for 30 minutes after completion of the dropwise addition. Subsequently, the temperature of the reaction system was raised to 0 °C and water was added dropwise to transform the suspension into a clarified solution. The organic layer was separated, washed with brine and dried to give 8.00 g of 1-benzyl-3-pyrrolidone in 90.90% yield and 95% HPLC purity.
References
[1] Patent: CN106938980, 2017, A. Location in patent: Paragraph 0026-0031
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2465 - 2469
1-Benzyl-3-pyrrolidinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 296 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
View Lastest Price from 1-Benzyl-3-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-17 | 1-Benzyl-3-pyrrolidinone
775-16-6
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
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2026-06-15 | 1-Benzyl-3-pyrrolidinone
775-16-6
|
$5.00 | 1kg | ≥98% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-04-17 | 1-Benzyl-3-pyrrolidinone
775-16-6
|
$2.20-8.80 | 1kg | 99% | 50kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 1-Benzyl-3-pyrrolidinone
775-16-6
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-Benzyl-3-pyrrolidinone
775-16-6
- $5.00
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- 1-Benzyl-3-pyrrolidinone
775-16-6
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
