ChemicalBook >> CAS DataBase List >>1-Hydroxybenzotriazole hydrate
1-Hydroxybenzotriazole hydrate
- CAS No.
- 123333-53-9
- Chemical Name:
- 1-Hydroxybenzotriazole hydrate
- Synonyms
- 1-HYDROXYBENZOTRIAZOLE MONOHYDRATE;HOBT HYDRATE;HOBT H2O;1H-benzo[d][1,2,3]triazol-1-ol hydrate;HOBT.H20;HOBT MONOHYDRATE;1-Hydroxybenzotriazole Hydrat;N-HYDROXYBENZOTRIAZOLE HYDRATE;N-HYDROXYBENZOTRIAZOLE MONOHYDRATE;1-Hydroxy-1H-benzotriazole Hydrate
- CBNumber:
- CB8775919
- Molecular Formula:
- C6H7N3O2
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00065690
- MOL File:
- 123333-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:51:31
| Product description | Number | Pack Size | Price |
| 1-Hydroxybenzotriazole hydrate wetted with not less than 14 wt. % water, 97% | 157260 | 25g | $89.1 |
| 1-Hydroxybenzotriazole hydrate wetted with not less than 14 wt. % water, 97% | 157260 | 100g | $210 |
| 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | TRC-H829500-250MG | 250mg | $81 |
| 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | TRC-H829500-1G | 1g | $119 |
| 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | TRC-H829500-10G | 10g | $180 |
| More product size | |||
| Melting point | 155-158 °C(lit.) |
|---|---|
| Boiling point | 248.8°C (rough estimate) |
| Density | 1.065 g/cm |
| refractive index | 1.6910 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMF: 100 mg/mL, clear |
| form | Solid |
| color | White to Off-White |
| Water Solubility | slightly soluble |
| BRN | 4515 |
| Stability | Hygroscopic |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2 |
| InChIKey | PJUPKRYGDFTMTM-UHFFFAOYSA-N |
| SMILES | ON1N=NC2C=CC=CC1=2.O |
| CAS DataBase Reference | 123333-53-9(CAS DataBase Reference) |
| FDA UNII | S72K7GY45F |
| UNSPSC Code | 12352000 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H207-H319-H412 |
| Precautionary statements | P210-P212-P230-P233-P280-P370+P380+P375-P501 |
| Hazard Codes | F |
| Risk Statements | 5-11-R5-R11-44-1 |
| Safety Statements | 15-16-35-7/9-33-S7/9-S33-S16-60-37-26 |
| RIDADR | UN 3474 (1-HYDROXYBENZOTRIAZOLE MONOHYDRATE) |
| WGK Germany | - |
| F | 4.10-8 |
| Hazard Note | Highly Flammable |
| HazardClass | 4.1 |
| PackingGroup | I |
| HS Code | 29339980 |
| Storage Class | 4.1A - Other explosive hazardous materials |
| Hazard Classifications | Aquatic Chronic 3 Desen. Expl. 2 Eye Irrit. 2 |
| Excepted Quantities | Not Permitted as Excepted Quantity |
1-Hydroxybenzotriazole hydrate price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 157260 | 1-Hydroxybenzotriazole hydrate wetted with not less than 14 wt. % water, 97% | 123333-53-9 | 25g | $89.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 157260 | 1-Hydroxybenzotriazole hydrate wetted with not less than 14 wt. % water, 97% | 123333-53-9 | 100g | $210 | 2026-04-30 | Buy |
| TRC | TRC-H829500-250MG | 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | 123333-53-9 | 250mg | $81 | 2026-06-03 | Buy |
| TRC | TRC-H829500-1G | 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | 123333-53-9 | 1g | $119 | 2026-06-03 | Buy |
| TRC | TRC-H829500-10G | 1-Hydroxybenzotriazole Hydrate >95%(HPLC) | 123333-53-9 | 10g | $180 | 2026-06-03 | Buy |
1-Hydroxybenzotriazole hydrate Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
Uses
A common additive for peptide coupling.
Uses
1-Hydroxybenzotriazole hydrate is used as an additive for oligonucleotide couplings and in racemization-free peptide couplings.
General Description
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
reaction suitability
reaction type: Addition Reactions
Toxics Screening Level
The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials
Global( 468)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 489 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
View Lastest Price from 1-Hydroxybenzotriazole hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 1-Hydroxybenzotriazole hydrate
123333-53-9
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-07 | 1-Hydroxybenzotriazole hydrate
123333-53-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-12-01 | 1-Hydroxybenzotriazole hydrate
123333-53-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 1-Hydroxybenzotriazole hydrate
123333-53-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-Hydroxybenzotriazole hydrate
123333-53-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1-Hydroxybenzotriazole hydrate
123333-53-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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HOBT hydrate [1-Hydroxybenzotriazole hydrate]
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CAS:123333-53-9
HOBt - hydrate wetted (>20 wt % water)
1-Hydroxybenzotriazole hydrate wetted (>20 wt % water)
N-HYDROXYBENZOTRIAZOLE MONOHYDRATE
1H-Benzo[d][1,2,3]triazol-1-ol xhydrate
1-Hydroxybenzotriazole hydrate (HOBt)
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