ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride
![ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride Structure](CAS/GIF/33400-45-2.gif)
- CAS No.
- 33400-45-2
- Chemical Name:
- ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride
- Synonyms
- Flupirtine HCl;Flupirtine Hydrochloride;ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride;ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate,hydrochloride
- CBNumber:
- CB8937085
- Molecular Formula:
- C15H18ClFN4O2
- Molecular Weight:
- 340.78
- MDL Number:
- MFCD01737882
- MOL File:
- 33400-45-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ETHYL 2-AMINO-6-[[P-FLUOROBENZYL]AMINO]PYRIDINE-3-CARBAMATE MONOHYDROCHLORIDE 95.00% | HCH0260627 | 5MG | $495.99 |
| FDA UNII | 224NM3F2WX |
|---|
ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0260627 | ETHYL 2-AMINO-6-[[P-FLUOROBENZYL]AMINO]PYRIDINE-3-CARBAMATE MONOHYDROCHLORIDE 95.00% | 33400-45-2 | 5MG | $495.99 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| HCH0260627 | 5MG | $495.99 | Buy |
ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride Chemical Properties,Uses,Production
Uses
Flupirtine hydrochloride (D 9998 hydrochloride) is a selective neuropotassium channel opener with analgesic activity. Flupirtine hydrochloride is used to inhibit a variety of pain conditions, including chronic musculoskeletal pain, migraines, and neuralgia. Flupirtine hydrochloride has antidepressant and antioxidant properties and may increase the analgesic effect in combination therapy with morphine. Flupirtine hydrochloride relieves abnormally increased muscle tension and has a muscle relaxant effect. Flupirtine hydrochloride is clinically superior to other drugs, such as tramadol and pantoxan, plus its side effects are better tolerated. Flupirtine hydrochloride has a significant effect on inhibiting neural hyperexcitability and therefore exhibits inhibitory potential in various pain states[1].
References
[1] Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106(9-10):857-67. DOI:10.1007/s007020050206
[2] Flupirtine in pain management: pharmacological properties and clinical use DOI:10.2165/11536230-000000000-00000
[3] Klinger F, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166(5):1631-42. DOI:10.1111/j.1476-5381.2011.01821.x
[4] Swedberg MD, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246(3):1067-74. PMID:2901483
[5] Wu SN, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403. DOI:10.1155/2012/148403
[6] Kolosov A, et al. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012 Nov;13(11):1444-56. DOI:10.1111/j.1526-4637.2012.01502.x
[7] Michel MC, et al. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br J Clin Pharmacol. 2012 May;73(5):821-5. DOI:10.1111/j.1365-2125.2011.04138.x
ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Artis Biotech Co. Ltd. | 19138486554 18108108965 | sales@artisbio.com | China | 2400 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29717 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Artis Biotech Co. Ltd. | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Flupirtine HCl
33400-45-2
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Flupirtine HCl
33400-45-2
- $1520.00-2500.00
- TargetMol Chemicals Inc.
