Ganciclovir Mono-O-acetate
- CAS No.
- 88110-89-8
- Chemical Name:
- Ganciclovir Mono-O-acetate
- Synonyms
- Monacetyl ganciclor;Mono acetyl Ganciclovir;Gancyclovir Impurity 20;Valganciclovir USP RC E;Ganciclovir Impurity 30;O-Monoacetylganciclovir;Ganciclovir Impurity 16;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate
- CBNumber:
- CB91176343
- Molecular Formula:
- C11H15N5O5
- Molecular Weight:
- 297.27
- MDL Number:
- MFCD09840659
- MOL File:
- 88110-89-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ganciclovir Mono-O-acetate | TRC-G235010-25MG | 25mg | $256 |
| Ganciclovir Mono-O-acetate | TRC-G235010-250MG | 250mg | $2098 |
| Ganciclovir Mono-O-acetate | TRC-G235010-100MG | 100mg | $931 |
| Ganciclovir mono-O-acetate | FG23646 | 5g | $900 |
| Ganciclovir mono-O-acetate | FG23646 | 50g | $900 |
| More product size | |||
| Melting point | 194-197°C |
|---|---|
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.32±0.20(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | VOP6XHY7OL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H351-H340 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| REACH Registrations | Active |
Ganciclovir Mono-O-acetate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-G235010-25MG | Ganciclovir Mono-O-acetate | 88110-89-8 | 25mg | $256 | 2026-06-03 | Buy |
| TRC | TRC-G235010-250MG | Ganciclovir Mono-O-acetate | 88110-89-8 | 250mg | $2098 | 2026-06-03 | Buy |
| TRC | TRC-G235010-100MG | Ganciclovir Mono-O-acetate | 88110-89-8 | 100mg | $931 | 2026-06-03 | Buy |
| Biosynth | FG23646 | Ganciclovir mono-O-acetate | 88110-89-8 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FG23646 | Ganciclovir mono-O-acetate | 88110-89-8 | 50g | $900 | 2026-06-04 | Buy |
Ganciclovir Mono-O-acetate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Ganciclovir derivative.
Synthesis
2466-76-4
82410-32-0
88110-89-8
The general procedure for the synthesis of 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate from 1-acetylimidazole and 2-amino-9-(((1,3-dihydroxypropan-2- yl)oxy)methyl)-1H-purin-6(9H)-one is as follows: 500.0 g (1.96 mol, 1.0 equiv) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq.) of trimethyl borate and 7.5 kg of toluene were added to the reaction vessel and heated to reflux for 5 hours. The progress of the reaction was monitored by TLC to confirm the complete reaction of the ingredients. The reaction mixture was cooled to room temperature and 396.7 g (3.93 mol, 2.0 eq.) of triethylamine was added, followed by 323.7 g (2.94 mol, 1.5 eq.) of 1-acetylimidazole, and stirred for 6 hours at room temperature. The ratio of monoacetyl ganciclovir to N,O-diacetyl ganciclovir was analyzed by HPLC to be 94:4. The reaction mixture was cooled to 0-10 °C and 2.0 kg of methanol was slowly added dropwise followed by stirring for 2 h at room temperature. The solvent was removed by concentration under reduced pressure, 3.0 kg of ethyl acetate was added, the organic layer was washed with 500 g of water and the aqueous layer was extracted with 500 g of ethyl acetate. The organic layers were combined, concentrated under reduced pressure and recrystallized by ethanol to give 440.9 g of colorless crystal product in 75.7% yield and 99.2% purity.
References
[1] Patent: CN108383840, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
[2] Patent: CN108503642, 2018, A. Location in patent: Paragraph 0028-0034; 0039; 0040; 0042-0050; 0053; 0054
[3] Patent: CN108503641, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0034; 0040-0051; 0054; 0055
[4] Patent: CN108409739, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
Ganciclovir Mono-O-acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from Ganciclovir Mono-O-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Ganciclovir mono-O-acetate
88110-89-8
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-01-04 | Ganciclovir Mono-O-acetate
88110-89-8
|
1kg | 99.0%min | 10tons | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2025-12-01 | Ganciclovir Mono-O-acetate
88110-89-8
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Ganciclovir mono-O-acetate
88110-89-8
- $0.00
- TargetMol Chemicals Inc.
-
- Ganciclovir Mono-O-acetate
88110-89-8
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- Ganciclovir Mono-O-acetate
88110-89-8
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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