thioperamide maleate salt
- CAS No.
- 148440-81-7
- Chemical Name:
- thioperamide maleate salt
- Synonyms
- MR-12842 maleate;Thioperamide maleate, H3 antagonist;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
- CBNumber:
- CB91216162
- Molecular Formula:
- C15H24N4SC4H4O4
- Molecular Weight:
- 0
- MDL Number:
- MFCD00083209
- MOL File:
- 148440-81-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Thioperamide maleate salt solid | T123 | 10mg | $144 |
| Thioperamide maleate salt solid | T123 | 25mg | $345 |
| Thioperamide (maleate) ≥98% | 10011127 | 1mg | $17 |
| Thioperamide (maleate) ≥98% | 10011127 | 5mg | $63 |
| Thioperamide (maleate) ≥98% | 10011127 | 10mg | $108 |
| storage temp. | desiccated under inert gas |
|---|---|
| solubility | H2O: >10mg/mL |
| form | solid |
| color | white |
| Water Solubility |
H2O: >10mg/mL DMSO: 12mg/mL ethanol: 3mg/mL |
| InChI | 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | REZRBLGMJZZSID-BTJKTKAUSA-N |
| SMILES | OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
thioperamide maleate salt price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T123 | Thioperamide maleate salt solid | 148440-81-7 | 10mg | $144 | 2026-04-30 | Buy |
| Sigma-Aldrich | T123 | Thioperamide maleate salt solid | 148440-81-7 | 25mg | $345 | 2026-04-30 | Buy |
| Cayman Chemical | 10011127 | Thioperamide (maleate) ≥98% | 148440-81-7 | 1mg | $17 | 2026-04-30 | Buy |
| Cayman Chemical | 10011127 | Thioperamide (maleate) ≥98% | 148440-81-7 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 10011127 | Thioperamide (maleate) ≥98% | 148440-81-7 | 10mg | $108 | 2026-04-30 | Buy |
thioperamide maleate salt Chemical Properties,Uses,Production
Description
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-
Uses
Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.
Biochem/physiol Actions
Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.
in vivo
Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[4].
| Animal Model: | Naive female C57BL/6J mice[4] |
| Dosage: | 5, 10 or 20 mg/kg |
| Administration: | Injections (i.p.) |
| Result: | Facilitated reconsolidation of a contextually-conditioned fear memory. |
IC 50
H3 Receptor
References
[1] GALINA MEIER . Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists[J]. European Journal of Pharmaceutical Sciences, 2001, 13 3: Pages 249-259. DOI: 10.1016/s0928-0987(01)00106-3
[2] CHIE HARADA. Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures[J]. Brain Research Bulletin, 2004, 63 2: Pages 143-146. DOI: 10.1016/j.brainresbull.2004.02.001
thioperamide maleate salt Preparation Products And Raw materials
Raw materials
Preparation Products
thioperamide maleate salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15491 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
View Lastest Price from thioperamide maleate salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Thioperamide maleate
148440-81-7
|
$35.00-129.00 | 99.88% | 10g | TargetMol Chemicals Inc. |
-
- Thioperamide maleate
148440-81-7
- $35.00-129.00
- 99.88%
- TargetMol Chemicals Inc.
