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N-Cbz-L-Aspartic acid 4-tert-butyl ester

N-Cbz-L-Aspartic acid 4-tert-butyl ester structure

CAS No.: 5545-52-8

Chemical Name:: N-Cbz-L-Aspartic acid 4-tert-butyl ester

Synonyms: Z-ASP(OTBU)-OH;ASP(OtBu)-OH;Cbz-Asp(OtBu)-OH;(S)-2-(((Benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid;Z-L-ASP(OTBU)-OH;CBZ-AMINOACID;Z-Asp(OBut).H2O;CBZ-ASP(OBUT)-OH;Z-Asp(OtBu)-OH H;Z-Asp(OtBu)-OH.H20

CBNumber:: CB9124864

Molecular Formula:: C16H21NO6

Molecular Weight:: 323.34

MDL Number:: MFCD00042857

MOL File:: 5545-52-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:15

Product description	Number	Pack Size	Price
Z-Asp(OtBu)-OH ≥98.0% (TLC)	02378	5g	$120
Z-Asp(OtBu)-OH	B6364	5G	$41
Z-Asp(OtBu)-OH	B6364	25G	$124
Cbz-L-Aspartic 4-tert-butyl ester Asreported	269290	1g	$333
Cbz-L-Aspartic 4-tert-butyl ester Asreported	269290	2g	$460
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N-Cbz-L-Aspartic acid 4-tert-butyl ester Properties

Boiling point	513.1±50.0 °C(Predicted)
Density	1.219±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO, and methanol.
pka	3.67±0.23(Predicted)
form	Powder
color	White to off-white
optical activity	29°(C=0.01g/mL, CHCL3, 20°C, 589nm)
BRN	2569846
Major Application	peptide synthesis
InChI	InChI=1S/C16H21NO6/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20)/t12-/m0/s1
InChIKey	HLSLRFBLVZUVIE-LBPRGKRZSA-N
SMILES	C(O)(=O)[C@H](CC(OC(C)(C)C)=O)NC(OCC1=CC=CC=C1)=O
CAS DataBase Reference	5545-52-8(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29224999

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

N-Cbz-L-Aspartic acid 4-tert-butyl ester price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	02378	Z-Asp(OtBu)-OH ≥98.0% (TLC)	5545-52-8	5g	$120	2026-04-30	Buy
TCI Chemical	B6364	Z-Asp(OtBu)-OH	5545-52-8	5G	$41	2026-04-30	Buy
TCI Chemical	B6364	Z-Asp(OtBu)-OH	5545-52-8	25G	$124	2026-04-30	Buy
Usbiological	269290	Cbz-L-Aspartic 4-tert-butyl ester Asreported	5545-52-8	1g	$333	2026-06-03	Buy
Usbiological	269290	Cbz-L-Aspartic 4-tert-butyl ester Asreported	5545-52-8	2g	$460	2026-06-03	Buy

Product number	Packaging	Price	Buy
02378	5g	$120	Buy
B6364	5G	$41	Buy
B6364	25G	$124	Buy
269290	1g	$333	Buy
269290	2g	$460	Buy

N-Cbz-L-Aspartic acid 4-tert-butyl ester Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

It is a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

540-88-5

1152-61-0

(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

47307-26-6

N-Cbz-L-Aspartic acid 4-tert-butyl ester

5545-52-8

42417-76-5

The general procedure for the synthesis of (S)-3-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid, N-benzyloxycarbonyl-L-aspartic acid 4-tert-butyl ester and Z-L-aspartic acid tert-butyl ester tert-butyl ester, using tert-butyl acetate and N-CBZ-L-aspartic acid, is as follows: an ester-exchange reaction system was set up according to the methodology described in Example 1 , but BF3 -Et2O was replaced with other catalysts. The catalysts tested included acids or salts as listed in Table I. The reaction was carried out at room temperature or at about 50°C for 5.5 to 15 hours. At the end of the reaction, the reaction mixtures were analyzed by HPLC technique as in Example 1. The results of Table I show that the ester exchange reaction in the presence of catalysts such as concentrated sulfuric acid (H2SO4), methanesulfonic acid (MsOH), zinc chloride (ZnCl2), and titanium tetrachloride in dichloromethane (TiCl4 in DCM), significantly produced Z-Asp(OtBu)2. In contrast, the catalytic effect of aluminum chloride (AlCl3), ferric chloride (FeCl3) and titanium tetraisopropoxide (Ti[OiPr]4) was not significant even under the conditions of increasing the reaction temperature and prolonging the reaction time.

References

[1] Patent: US2003/236430, 2003, A1. Location in patent: Page 3

N-Cbz-L-Aspartic acid 4-tert-butyl ester synthesis

Synthesis of N-Cbz-L-Aspartic acid 4-tert-butyl ester from Z-ASP(OTBU)-OME

N-Cbz-L-Aspartic acid 4-tert-butyl ester Preparation Products And Raw materials

Raw materials

4-Oxazolidineacetic acid, 5-oxo-3-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester, (4S)- TERT-BUTYL PROPIONATE Z-ASP(OTBU)-OME tert-Butyl bromoacetate BENZOIC ACID TERT-BUTYL ESTER

TERT-BUTYL FORMATE tert-Butyl methyl ether tert-Butyl methacrylate tert-Butyl acetate N-Carbobenzyloxy-L-aspartic acid

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Preparation Products

L-Aspartic acid 4-tert-butyl ester N-Carbobenzyloxy-L-aspartic acid

N-Cbz-L-Aspartic acid 4-tert-butyl ester Suppliers

Global( 270)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3991	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from N-Cbz-L-Aspartic acid 4-tert-butyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-08	N-Cbz-L-Aspartic acid 4-tert-butyl ester 5545-52-8		1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
	2019-07-06	N-Cbz-L-Aspartic acid 4-tert-butyl ester 5545-52-8	$100.00	1KG	99%		Career Henan Chemical Co

N-Cbz-L-Aspartic acid 4-tert-butyl ester
5545-52-8
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

N-Cbz-L-Aspartic acid 4-tert-butyl ester
5545-52-8
$100.00
99%
Career Henan Chemical Co

N-Cbz-L-Aspartic acid 4-tert-butyl ester Spectrum

N-Cbz-L-Aspartic acid 4-tert-butyl ester(5545-52-8)¹HNMR

5545-52-8(N-Cbz-L-Aspartic acid 4-tert-butyl ester)Related Search:

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Tris(trimethylsilyl)phosphate N-Carbobenzyloxyglycine Sodium L-aspartate L-Aspartic acid L-ASPARTIC ACID

Z-ASP(OTBU)-OH DCHA N-Carbobenzyloxy-L-aspartic acid Z-ASP-OME N-Benzyloxycarbonyl-L-asparagine Z-Asp(OtBu)-Glu(OtBu)-OH

N-Cbz-L-Aspartic acid 4-benzyl ester Z-Asp(OtBu)-His(Trt)-OH Z-ASP(OME)-OH

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CBZ-L-ASPARTIC ACID 4-TERT-BUTYL ESTER N-CBZ-L-ASPARTIC ACID 4-TERT-BUTYL ESTER N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 4-TERT-BUTYL ESTER 4-tert-butyl hydrogen N-[(phenylmethoxy)carbonyl]-L-aspartate Z-L-aspartic acid β-tert·butyl ester monohydrate N-CBZ-L-ASPARTIC ACID-B-T-BUTYL ESTER N-ALPHA-BENZYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER 1-HYDRATE CBZ-ASP(OBUT)-OH Z-ASPARTIC ACID(OTBU)-OH Z-L-ASPARTIC ACID 4-TERT-BUTYL ESTER Z-Asp(OtBu)-OH.H20 Z-Aspartic acid, 4-tert-Butyl ester, H20 Z-L-aspartic acid ?-tert-butyl ester monohydrate99% N-carbobenzyloxy-L-aspartic acid beta-tert-butyl ester Z-L-Aspartic acid 4-tert-butyl ester, N-Cbz-L-aspartic acid 4-tert-butyl ester (S)-2-[(Benzyloxycarbonyl)amino]-4-oxo-4-tert-butoxybutanoic acid Cbz-L-αβAsp-(OCMe3)-OH N-(Benzyloxycarbonyl)-3-(tert-butoxycarbonyl)-L-alanine N-[(Benzyloxy)carbonyl]-L-aspartic acid 4-(1,1-dimethylethyl) ester Cbz-L-Aspartic 4-tert-butyl ester Z-Asp-(OtBu)-OHmonohydrate CBZ-ASP(OTBU)-OH/Z-Asp(OtBu)-OH (2S)-2-(benzyloxycarbonylamino)-4-tert-butoxy-4-keto-butyric acid (2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid CBZ-Asp(OtBu)-OH.H20 Z-L-aspartic acid beta-tert-butyl ester dicyclohexylaMMoniuM salt Z-Asp(OtBu)-OH·H2O Z-L-aspartic acid β-tert·butyl ester Monohydrate Z-L-ASPARTIC ACID-B-T BUTYLESTER MONOHYDRATE CBZ-AMINOACID CBZ-L-ASPARTIC ACID .BETA.-TERT-BUTYL ESTER MONOHYDRATE N-Carbobenzyloxy-L-aspartic acid β-tert butyl ester Cbz-L-Asp(OtBu)-OH Z-L-aspartic acid β-tert-butyl ester dicyclohexylammonium salt≥ 98% (HPLC) (S)-3-(((Benzyloxy)carbonyl)aMino)-5-isopropoxy-5-oxopentanoic Acid Z-Asp(OtBu)-OH >=98.0% (TLC) Z-Asp(OtBu)-OH H Z-L-Asp(OtBu)-OH DCHA Z-Asp(OBut).H2O 4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid Z-Aspartic Acid, Alpha-Tert-Butyl Ester Dicyclohexylammonium Salt L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester N-Benzyloxycarbonyl-L-asparticacid4-tert-butylester,98% (2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoicaci N-Cbz-L-Aspartic acid 4-tert-butyl ester USP/EP/BP N- benzyloxycarbonyl -L- aspartate 4- tert-butyl ester 4-(1,1-Dimethylethyl) hydrogen N-[(phenylmethoxy)carbonyl]-L-aspartate N-Benzyloxycarbonyl-L-aspartic acid-beta-tert-butyl ester Z-Asp(OtBu)-OH 4-(tert-Butyl) hydrogen N-CBZ-L-aspartate L-aspartic acidaminoacid,N-[((phenylmethoxy)carbonyl]-,4-(1,1-dimethyl)ester (S)-2-(((Benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid ASP(OtBu)-OH Cbz-Asp(OtBu)-OH Z-ASP(OTBU)-OH Z-L-ASP(OTBU)-OH 5545-52-8 CH33CO2CCH2CHNHCO2CH2C6H5CO2H C16H23NO7

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