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2-Hydroxy-3-cyanopyridine

2-Hydroxy-3-cyanopyridine structure

CAS No.: 20577-27-9

Chemical Name:: 2-Hydroxy-3-cyanopyridine

Synonyms: 2-Hydroxynicotinonitrile;3-Cyano-2-pyridone;3-Cyano-2-pyridinol;3-CYANO-2(1H)-PYRIDINONE;3-Cyano-1H-pyridin-2-one;3-Cyanopyridin-2(1H)-one;2-Hydroy-3-cyanopyridine;2-Hydroxy-3-cycnopyridine;2-Hydroxy-3-cyanopyridine;2-HYDROXY-3-PYRIDINECARBONITRILE

CBNumber:: CB9141849

Molecular Formula:: C6H4N2O

Molecular Weight:: 120.11

MDL Number:: MFCD00661865

MOL File:: 20577-27-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:30:17

Product description	Number	Pack Size	Price
2-Hydroxy-3-cyanopyridine	TRC-H825140-500MG	500mg	$65
2-Hydroxy-3-cyanopyridine	TRC-H825140-2G	2g	$109
2-Hydroxy-3-cyanopyridine	TRC-H825140-1G	1g	$72
3-Cyano-2-hydroxypyridine	FC09747	10g	$150
3-Cyano-2-hydroxypyridine	FC09747	5g	$150
More product size

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2-Hydroxy-3-cyanopyridine Properties

Melting point	90-94
Boiling point	352.3±35.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in dimethyl sulfoxide.
form	Solid
pka	8.93±0.10(Predicted)
InChI	InChI=1S/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)
InChIKey	DYUMBFTYRJMAFK-UHFFFAOYSA-N
SMILES	C1(=O)NC=CC=C1C#N
CAS DataBase Reference	20577-27-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

22-41

Safety Statements

26-39

RIDADR

UN3439

Hazard Note

Irritant/Keep Cold

HazardClass

6.1

HS Code

2933399990

NFPA 704

	1
2		0

2-Hydroxy-3-cyanopyridine price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-H825140-500MG	2-Hydroxy-3-cyanopyridine	20577-27-9	500mg	$65	2026-06-03	Buy
TRC	TRC-H825140-2G	2-Hydroxy-3-cyanopyridine	20577-27-9	2g	$109	2026-06-03	Buy
TRC	TRC-H825140-1G	2-Hydroxy-3-cyanopyridine	20577-27-9	1g	$72	2026-06-03	Buy
Biosynth	FC09747	3-Cyano-2-hydroxypyridine	20577-27-9	10g	$150	2026-06-04	Buy
Biosynth	FC09747	3-Cyano-2-hydroxypyridine	20577-27-9	5g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-H825140-500MG	500mg	$65	Buy
TRC-H825140-2G	2g	$109	Buy
TRC-H825140-1G	1g	$72	Buy
FC09747	10g	$150	Buy
FC09747	5g	$150	Buy

2-Hydroxy-3-cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

Dark Yellow Solid

Uses

2-Hydroxy-3-cyanopyridine (cas# 20577-27-9) is a compound useful in organic synthesis.

Definition

ChEBI: 3-cyano-2-pyridone is a member of pyridines and a nitrile.

Synthesis

6602-54-6

20577-27-9

The general procedure for the synthesis of 2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-chloro-3-cyanopyridine was as follows: acetic acid (826 mL) was slowly added to 2-chloro-3-cyanopyridine (250 g), and the mixture was subsequently heated to reflux and held for 48 hours. Upon completion of the reaction, the reaction mixture was quenched by careful pouring into an ice-water mixture. The resulting precipitate was collected by filtration, washed well with deionized water and dried under appropriate conditions to give the target product 2-hydroxy-3-cyanopyridine. The yield of this step was 95%. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.57 (s, 1H), 8.16 (dd, J = 3.6 Hz, 1H), 7.80 (dd, J = 3.6 Hz, 1H), 6.37 (t, 1H); the mass spectrum (ES) showed m/z of 121.

References

[1] Tetrahedron Letters, 2004, vol. 45, # 35, p. 6633 - 6636
[2] Patent: WO2014/207508, 2014, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7624 - 7643
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5738 - 5746
[5] Synthetic Communications, 2011, vol. 41, # 19, p. 2859 - 2869

2-Hydroxy-3-cyanopyridine synthesis

Synthesis of 2-Hydroxy-3-cyanopyridine from 2-Chloro-3-cyanopyridine

2-Hydroxy-3-cyanopyridine Preparation Products And Raw materials

Raw materials

2-Chloro-3-cyanopyridine

Preparation Products

2-Hydroxynicotinic acid 2-HYDROXY-5-NITRONICOTINONITRILE 5-Bromo-3-cyano-2-hydroxypyridine

2-Hydroxy-3-cyanopyridine Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 2-Hydroxy-3-cyanopyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	2-Hydroxy-3-cyanopyridine 20577-27-9	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2025-06-25	2-Hydroxy-3-cyanopyridine 20577-27-9	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-10-16	2-Hydroxy-3-cyanopyridine 20577-27-9	$10.00	1KG	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
$10.00
99%
Hebei Zhanyao Biotechnology Co. Ltd

2-Hydroxy-3-cyanopyridine Spectrum

2-Hydroxy-3-cyanopyridine(20577-27-9)¹HNMR

20577-27-9(2-Hydroxy-3-cyanopyridine)Related Search:

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Milrinone RICININE 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE 3-Cyano-6-methyl-2(1H)-pyridinone 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one

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2-Hydroxy-3-cycnopyridine 2-Oxo-2,3-dihydropyridine-3-carbonitrile 3-CYANO-2(1H)-PYRIDINONE 2-HYDROXY-3-PYRIDINECARBONITRILE 2-Hydroxy-3-cyanopyridine 1,2-Dihydro-2-oxopyridine-3-carbonitrile 1,2-Dihydropyridine-2-oxo-3-carbonitrile 3-Cyano-1H-pyridin-2-one 1,2-Dihydro-2-oxopyridine-3-carbonitrile 98% 2-Hydroxypyridine-3-carbonitrile, 3-Cyano-2-hydroxypyridine 1,2-Dihydropyridine-2-oxo-3-carbonitrile98% 3-Cyanopyridin-2(1H)-one 3-Cyano-2-pyridinol 3-Cyano-2-pyridone 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo- 2-Hydroxy-3-cyanopyridine ISO 9001：2015 REACH 2-Hydroy-3-cyanopyridine 2-oxo-1,2-dihydropyridine-3-carbonitrile2-hydroxy-3-cyanopyridine 2-Oxo-1,2-dihydropyridin-3-carbonitrile2-hydroxy-3-cyano-pyridine 2-Hydroxynicotinonitrile 20577-27-9 200577-27-9 Bases & Related Reagents Nucleotides Nucleotides and Nucleosides CHIRAL CHEMICALS cyanide| alcohol Heterocycle-Pyridine series Pyridine blocks Carboxes Pyridines Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis Building Blocks C6

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