ChemicalBook >> CAS DataBase List >>6-Hydroxy-2(1H)-3,4-dihydroquinolinone
6-Hydroxy-2(1H)-3,4-dihydroquinolinone
- CAS No.
- 54197-66-9
- Chemical Name:
- 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
- Synonyms
- 6-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE;Cilostazol Related CoMpound A;6-HYDROXY-3,4-DIHYDROCARBOSTYRIL;6-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;Q-2;6-HQ;in-2(1H)-one;AURORA KA-4814;6-Hydroxy-2-oxo-1
- CBNumber:
- CB9143232
- Molecular Formula:
- C9H9NO2
- Molecular Weight:
- 163.17
- MDL Number:
- MFCD02179410
- MOL File:
- 54197-66-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 03:50:39
| Product description | Number | Pack Size | Price |
| Cilostazol Related Compound A pharmaceutical secondary standard, certified reference material | PHR2855 | 100MG | $539 |
| Cilostazol Related Compound A United States Pharmacopeia (USP) Reference Standard | 1134164 | 50mg | $1290 |
| 6-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97% | 675350 | 1g | $27.1 |
| 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) | D3448 | 5g | $49 |
| 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) | D3448 | 25g | $147 |
| More product size | |||
| Melting point | 236-240 °C |
|---|---|
| Boiling point | 424.5±45.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 9.86±0.20(Predicted) |
| form | solid |
| color | White to Almost white |
| InChI | InChI=1S/C9H9NO2/c11-7-2-3-8-6(5-7)1-4-9(12)10-8/h2-3,5,11H,1,4H2,(H,10,12) |
| InChIKey | HOSGXJWQVBHGLT-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(O)C=C2)CCC1=O |
| CAS DataBase Reference | 54197-66-9(CAS DataBase Reference) |
| FDA UNII | 2C5NDT39OC |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933790002 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
6-Hydroxy-2(1H)-3,4-dihydroquinolinone price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2855 | Cilostazol Related Compound A pharmaceutical secondary standard, certified reference material | 54197-66-9 | 100MG | $539 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1134164 | Cilostazol Related Compound A United States Pharmacopeia (USP) Reference Standard | 54197-66-9 | 50mg | $1290 | 2026-04-30 | Buy |
| Sigma-Aldrich | 675350 | 6-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97% | 54197-66-9 | 1g | $27.1 | 2023-06-20 | Buy |
| TCI Chemical | D3448 | 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) | 54197-66-9 | 5g | $49 | 2026-04-30 | Buy |
| TCI Chemical | D3448 | 3,4-Dihydro-6-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) | 54197-66-9 | 25g | $147 | 2026-04-30 | Buy |
6-Hydroxy-2(1H)-3,4-dihydroquinolinone Chemical Properties,Uses,Production
Chemical Properties
6-Hydroxy-2(1H)-3,4-dihydroquinolinone Appearance is white to almost white powder to crystal, Melting point 238°C, Store at -20° C.
Uses
A metabolite of Cilostazole.
Synthesis
19313-87-2
54197-66-9
2) 98 g of 3-chloro-N-(4-methoxyphenyl)acrylamide obtained from step 1) was mixed with N-(4-methoxyphenyl)-3-chloroacrylamide, 500 mL of tetrahydrofuran and 98 g of palladium chloride. The reaction mixture was heated to 100 °C under 5 MPa pressure and maintained at that temperature. Upon completion of the reaction, it was cooled to room temperature and then maintained at 110°C for 3 hours. Subsequently, filtration was performed and the filtrate was rotary evaporated to dryness to obtain 6-hydroxy-3,4-dihydro-2(1H)-quinolone crude.3) The 6-hydroxy-3,4-dihydro-2(1H)-quinolone crude obtained in step 2) was dissolved in 50 mL of ethanol, recrystallized and decolorized using activated carbon. After filtration, 74 g of 6-hydroxy-3,4-dihydro-2(1H)-quinolinone was obtained as an off-white solid in 95% yield. The total yield was 85%.
References
[1] Patent: CN108383781, 2018, A. Location in patent: Paragraph 0033; 0034
[2] Patent: CN107325078, 2017, A. Location in patent: Paragraph 0039-0040; 0043-0044; 0046-0047; 0049-0050; 0052
[3] Journal of the Chinese Chemical Society, 2000, vol. 47, # 1, p. 155 - 162
[4] Heterocycles, 2009, vol. 78, # 1, p. 189 - 195
[5] Asian Journal of Chemistry, 2011, vol. 23, # 4, p. 1655 - 1660
6-Hydroxy-2(1H)-3,4-dihydroquinolinone Preparation Products And Raw materials
Global( 399)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
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- Oct 20，2025
View Lastest Price from 6-Hydroxy-2(1H)-3,4-dihydroquinolinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
54197-66-9
|
$9.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-04-17 | 6-Hydroxy-3,4-dihydroquinolin-2(1H)-one
54197-66-9
|
$2.20-8.80 | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-12-24 | 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
54197-66-9
|
$886.00 | 1ASSAYS | 98% | 1T | Shaanxi Dideu Medichem Co. Ltd |
-
- 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
54197-66-9
- $9.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 6-Hydroxy-3,4-dihydroquinolin-2(1H)-one
54197-66-9
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
54197-66-9
- $886.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
54197-66-9(6-Hydroxy-2(1H)-3,4-dihydroquinolinone)Related Search:
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CHLOROPHOSPHONAZO III
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6-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE,6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE
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TQ(3,4-DIHYDRO-6-HYDROXY-2(1H)QUINOLINONE)
Hydroxyl-3,4-dihydrocarbostyril
6-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 6-Hydroxy-3,4-dihydrocarbstyril
3,4-Dihydro-2,6-quinolinediol
3,4-Dihydro-6-hydroxyquinoline-2(1H)-one
6-Hydroxy-3,4-dihydroquinoline-2(1H)-one
AURORA KA-4814
2(1H)-Quinolinone, 3,4-dihydro-6-hydroxy-
6-Hydroxy-3,4-dihydro-2(1H)-quinolinone,6-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 6-Hydroxy-3,4-dihydrocarbstyril
4-tetrahydroquinoline
6-Hydroxy-2-oxo-1
Cilostazol Related Compound A (50 mg) (6-hydroxy-3,4-dihydro-1H-quinolin-2-one)
6-Hydroxy-3,4-dihydro-2(1H)-quinolinone
6-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline
6-hydroxy-3,4-dihydroquinazolone
(Cilostazol)
6-Hydroxy-3,4-dihydro-2(1H)-quinolinone
6-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97%
3,4-Dihydro-6-hydroxy-2(1H)-quinolinone
3,4-DIHYDRO-6-HYDROXYQUINOLINONE
3,4-DIHYDRO-6-HYDROXY-2(1H)-QUINOLINONE
6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ)
6-Hydroxyl-3.4-dihydro-2-(1H)-quinolinone
Intermediate of Cilostazol
6-HYDROXY-3,4-DIHYDRO-2-QUINOLINONE
6-HYDROXY-3,4-DIHYDROCARBSTYRIL
6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE
6-HYDROXY-3,4-DIHYDROQUINOLONE
3,4-Dihydro-6-hydroxycarbostyril
3,4-Dihydro-6-hydroxy-carbostyril
6-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin
6-Hydroxy-3,4-dihydro-1H-quinoline-2-one
3,4-Dihydro-6-hydroxyquinolin-2(1H)-one
6-HYDROXY-2(1H)-3,4-DIHYDROQUINOLINONE CILOSTAZOL INTERMEDIATE
6-HIDROXY-2(1H)-3,4-DIHYDROQUINOLINONE
6-HYDRO-2(1H)-3,4-DIHYDROQUINOLINONE
6-Hydroxy-1,3,4-trihydroquinolin-2-one
6-HYDROXY-1,2,3,4-TETRAHYDRO-2-QUINOLINONE
6-HYDROXY-2(1H)-3,4-DIHYDROQUINOLINONE
6-HQ
6-HYDROXYL-3,4-DIHYDROCARBOSTYRIL
The intermediate of Cilostazol
3,4-Dihydro-6-hydroxy-2-(IH)-quinolinone
6-Hydroxy-1,2,3,4-tetrahydro-2-oxoquinoline
Hydroxyl-3,4-Dihydrocarbostyril(ForCilostazol)
Q-2
3,4-Dihydro-6-hydroxycarbostyril-2(1H)quinolinone
Cilostazol USP Related Compound A
Brexpiprazole Impurity 72
6-Hydroxy-3,4-Dihydroquinolinone(For Cilostazol)
3,4-Dihydro-6-hydroxyquinolin-2(1H)-one 98%
1,2,3,4-Tetrahydro-6-hydroxy-2-oxoquinoline
6-Hydroxy-2(1H)-3,4-dihydroquinolinone
(Cilostazol)
6-Hydroxy-3,4-dihydro-1H-quinolin-2
3,4-Dihydro-6-hydroxy-2(1H)-quinolinone>
6-hydroxy-3,4-dihydroquinoL
in-2(1H)-one
6-Hydroxy-2(1H)-3,4-dihydroquinolinone [Q2]
Cilostazol USP RC A
