Fenbendazole
- CAS No.
- 43210-67-9
- Chemical Name:
- Fenbendazole
- Synonyms
- Febendazole;fenbendazol;Fenbedazole;5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester;Methyl (6-(phenylthio)-1H-benzo[d]iMidazol-2-yl)carbaMate;[5-(Phenylthio)-1H-benzimidazol-2-yl]carbonic acid, Methyl ester;hoe881;Axilur;Fenbion;PANACUR
- CBNumber:
- CB9154575
- Molecular Formula:
- C15H13N3O2S
- Molecular Weight:
- 299.35
- MDL Number:
- MFCD00144301
- MOL File:
- 43210-67-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fenbendazole European Pharmacopoeia (EP) Reference Standard | F0040000 | 150 mg | $254 |
| Fenbendazole British Pharmacopoeia (BP) Reference Standard | BP692 | 100mg | $282 |
| Fenbendazole United States Pharmacopeia (USP) Reference Standard | 1269403 | 100mg | $1310 |
| Fenbendazole VETRANAL , analytical standard | 35032 | 100mg | $63.8 |
| Fenbendazole >98.0%(HPLC)(N) | F0812 | 25g | $122 |
| More product size | |||
| Melting point | 233°C |
|---|---|
| Density | 1.2767 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C |
| Water Solubility | Insoluble in water |
| solubility |
DMSO:16.67(Max Conc. mg/mL);55.69(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);33.41(Max Conc. mM) |
| pka | 10.80±0.10(Predicted) |
| form | Solid |
| color | White to Light yellow |
| Merck | 14,3960 |
| BRN | 759077 |
| InChI | InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) |
| InChIKey | HDDSHPAODJUKPD-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)NC1NC2=CC(SC3=CC=CC=C3)=CC=C2N=1 |
| CAS DataBase Reference | 43210-67-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 621BVT9M36 |
| ATC code | P02CA06 |
| EPA Substance Registry System | Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (43210-67-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361fd-H373-H410 |
| Precautionary statements | P201-P202-P260-P273-P280-P308+P313 |
| target organs | Liver,lymph node,Stomach,Nervous system |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 2 |
| RTECS | DD6520500 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Repr. 2 STOT RE 2 |
| Toxicity | dog,LD50,oral,> 500mg/kg (500mg/kg),Pesticide Science. Vol. 8, Pg. 550, 1977. |
Fenbendazole price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F0040000 | Fenbendazole European Pharmacopoeia (EP) Reference Standard | 43210-67-9 | 150 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP692 | Fenbendazole British Pharmacopoeia (BP) Reference Standard | 43210-67-9 | 100mg | $282 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1269403 | Fenbendazole United States Pharmacopeia (USP) Reference Standard | 43210-67-9 | 100mg | $1310 | 2026-04-30 | Buy |
| Sigma-Aldrich | 35032 | Fenbendazole VETRANAL , analytical standard | 43210-67-9 | 100mg | $63.8 | 2025-07-31 | Buy |
| TCI Chemical | F0812 | Fenbendazole >98.0%(HPLC)(N) | 43210-67-9 | 25g | $122 | 2026-04-30 | Buy |
Fenbendazole Chemical Properties,Uses,Production
Benzimidazole anthelmintics
Fenbendazole is a benzimidazole anthelmintic with a broad spectrum,high efficiency and low toxicity ,in the structure,it has a strong affinity with the parasite tubulin ,by influencing cell transport and energy metabolism,it plays a role in preventing the polymerization of micro tubes, which ultimately destroys the integrity of parasite cells and energy transmission.
Fenbendazole is used to drive and to kill the animal gastrointestinal parasites, it not only has a highly anthelmintic activity on animal gastrointestinal roundworms, hookworms, whipworms, some tapeworms and nematodes , but also has a preferred effect on the part of the bronchial tree and lung parasites (Aelurostrongylus abstrutus and lung fluke) .
Aofendazuo
Aofendazuo is a benzimidazole anthelmintic, also known as the Austrian phenol metronidazole, oxfendazole, benzene etomidate sulfoxide, benzene sulfur oxygen imidazole ,it is the sulfoxide form of Fenbendazole , white or off-white powder at room temperature, slight special smell, it can damage the microtubules of the worms epithelial cells of the gastrointestinal tract, and inhibit the worms uptake of glucose from the intestine.
Aofendazuo is used for the treatment and control of gastrointestinal adults and larvae, it has a good effect on the treatment of in vivo roundworms and lung worms in pigs and sheep , including Oster nematodes (Ostertagia), Haemonchus , Trichostrongylus, Nematodirus , Cooper nematode (Cooperia), capillary nematodes (Capillaria), toothed Oesophagostomum (Oesophagostomum), Chabertia, Trichuris nematodes form (Trichuris) and dictyocaulasis ( Dictyocaulus) and so on.
The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties
Gray light brown crystalline powder. Melting point 233 ℃ (decomposition). Soluble in dimethyl sulfoxide (DMSO), slightly soluble in common organic solvents, insoluble in water. Odorless, tasteless.
Uses
Anthelmintic. Broad-spectrum, high efficiency, low toxicity, antiparasitic. It has a strong killing effect on Roundworm, nematodes, tapeworms, cysticercosis , Fasciola and other parasites, not only killing worms, especially having a great effect on Transitional larvae ehich are hazardous to the liver, lungs and intestines .Fenbendazole is a benzimidazole anthelmintic, not only having a highly anthelmintic activity for gastrointestinal nematodes adults and larvae , but also having a good effect on dictyocaulasis, flukes and tapeworms, in addition,it has a strong killing eggs effect.
Production method
5-chloro-2-nitroaniline reacts with benzene thiol, to thereby obtain 5-phenylthio-2-nitroaniline in 91% yield.Generate 3-phenylthio-o-phenylenediamine by ferrous sulfate-iron reduction in 90% yield. Finally, cyclize it with the S-methyl-melamine Methyl to obtain fenbendazole.
Description
Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.
Chemical Properties
Off-White Solid
Originator
Panacur,Hoechst,W. Germany,1980
Uses
Fenbendazole is a benzimidazole anthelmintic that is metabolised in mammals to a series of other benzimidazoles including oxfendazole. It is used for the control of gastrointestinal roundworms, lung worms, Nematodes and tape worms. It is the only benzimidazole approved for use in organic livestock production.
Uses
Fenbendazole is a medication used to treat parasites, mainly in dogs. However, studies have found that in a group of mice treated with a combination of fenbendazole and vitamins, tumor growth inhibition was unexpected It may be because it interferes with the uptake of glucose by cancer cells, which is essential for tumor growth and proliferation. It prevents cancer cells from obtaining the glucose needed to grow and divide to inhibit the growth of cancer cells. Studies have found that fenbendazole can kill cancer cells and promote tumor regression in patients with metastatic large B-cell lymphoma, and also plays a role in other metastatic malignant tumors such as bladder cancer and renal cell carcinoma. It is currently being treated in combination with other anti-cancer drugs to study its anti-cancer potential[1-3].
Definition
ChEBI: Fenbendazole is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. It has a role as an antinematodal drug. It is a member of benzimidazoles, a carbamate ester and an aryl sulfide.
Manufacturing Process
20.9 g of S-methyl-thiourea were dissolved in 27 ml of water with 13.5 ml of chloroformic acid methyl ester. Then, 45.7 ml of 25% sodium hydroxide solution were added dropwise, while stirring, at a temperature of 5°C to 10°C. After having stirred for 20 minutes, the reaction mixture was combined with 27 ml of glacial acetic acid, 100 ml of water and 29 g of 3,4-diaminodiphenyl- thioether. Stirring was continued for 90 minutes at a temperature of 85°C, during which time methyl-mercaptan was separated. After having allowed the whole to cool and stand overnight, the 5-phenylmercaptobenzimidazole- 2-methyl-carbamate that had formed was filtered off with suction. After recrystallization from a mixture of glacial acetic acid and methanol, 14 g of 4-phenylmercapto-benzimidazole-2-methyl-carbamate melting at 233°C were obtained.
brand name
Panacur (Hoechst-Roussel).
Therapeutic Function
Anthelmintic
General Description
Fenbendazole is a thio substituted benzimidazole, which belongs to the group of anthelmintics. It can be widely used in veterinary medicine particularly, in the treatment of helminth infections.
Side effects
According to the results of toxicological studies, fenbendazole appears to be a safe drug, but up to 5% of people may experience stomach pain or diarrhea if taken in large amounts without interruption. People with severe renal failure or liver failure have a reduced level of drug excretion, and since fenbendazole powder is metabolized mainly in the liver, long-term heavy use can cause an asymptomatic increase in liver enzymes.
Veterinary Drugs and Treatments
Fenbendazole is indicated (labeled) for the removal of the following parasites in dogs: ascarids (Toxocara canis, T. leonina), Hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis). It is not effective against Dipylidium caninum. Fenbendazole has also been used clinically to treat Capillaria aerophilia, Filaroides hirthi, and Paragonimus kellicotti infections in dogs.
Fenbendazole is indicated (labeled) for the removal of the following parasites in cattle: Adult forms of: Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus axei, Bunostomum phlebotomum, Nematodirus helvetianus, Cooperia spp., Trichostrongylus colubriformis, Oesophagostomum radiatum, and Dictyocaulus vivaparus. It is also effective against most immature stages of the above listed parasites. Although not approved, it has good activity against Moniezia spp., and arrested 4th stage forms of Ostertagia ostertagi. Fenbendazole is indicated (labeled) for the removal of the following parasites in horses: large strongyles (S. edentatus, S. equinus, S. vulgaris), small strongyles (Cyathostomum spp., Cylicocylus spp., Cylicostephanus spp., Triodontophorus spp.), and pinworms (Oxyuris equi).
Fenbendazole is indicated (labeled) for the removal of the following parasites in swine: large roundworms (Ascaris suum), lungworms (Metastrongylus pair), nodular worms (Oesphagostomum dentatum, O. quadrispinolatum), small stomach worms (Hyostrongylus rubidus), whipworms (Trichuris suis), and kidney worms (Stephanurus dentatus; both mature and immature).
Although not approved, fenbendazole has been used in cats, sheep, goats, pet birds, and llamas.
Mode of action
Fenbendazole is a benzimidazole antiparasitic drug that works at the sub-cellular level preventing cell division. Benzimidazoles bind to the β-tubulin, inhibiting the cell’s microtubule assembly responsible for intracellular transport and required for mitotic cellular division. In effect, it starves the parasite by causing intestinal cell disruption.
References
[1] Gao P, et al. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. Journal of the American Association for Laboratory Animal Science : JAALAS, 2008.
[2] Park D, et al. Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells. The Korean Journal of Physiology Pharmacology, 2022; 26: 377-387.[3] Shin Y, et al. Anticancer Evaluation of Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles Encapsulating Fenbendazole and Rapamycin in Ovarian Cancer. International Journal of Nanomedicine, 2023; 2023: 2209—2223.
Fenbendazole Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yiwu Fengjin Commercial Company | +86-19164429943 +86-19164429943 | jaspercc0416@163.com | China | 1000 | 58 |
| Hebei ZB Gamay Biological Technology Co.,Ltd | +8617330018573 | info@zbvet.net | China | 263 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 143 | 58 |
| Forest chemical technology | +86-13854236000; +8613854236000 | grant@forestchem.freeqiye.com | China | 296 | 58 |
| Wuhan Biocar Pharmacy CO.,Ltd. | +86-86-13343427080 +8613343427080 | wxxxxxxj@gmail.com | China | 495 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3364 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5983 | 58 |
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View Lastest Price from Fenbendazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-08 | fenbendazole
43210-67-9
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1kg | 99 | 100kg | Forest chemical technology | ||
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2026-06-08 | Fenbendazole
43210-67-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-06-08 | Fenbendazole
43210-67-9
|
1kg | 99% | 1888kgs | Xi an Biohorlden Industry Trade Co Ltd |
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- fenbendazole
43210-67-9
- 99
- Forest chemical technology
-
- Fenbendazole
43210-67-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Fenbendazole
43210-67-9
- 99%
- Xi an Biohorlden Industry Trade Co Ltd
