FURIN
- CAS No.
- 141760-45-4
- Chemical Name:
- FURIN
- Synonyms
- FURIN;Furin human
- CBNumber:
- CB9159015
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03456906
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| Furin human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) | SRP6274 | 10μg | $674 |
| Furin human ≥2,000?unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells | F2677 | 50units | $504 |
| FURIN PurifiedbyProteinGaffinitychromatography. | 563092 | 50ug | $509 |
| FURIN PurifiedbyProteinGaffinitychromatography. | 563092 | 100ug | $708 |
| Furin PurifiedbyProteinAandpeptideaffinitychromatography. | 546980 | 200ul | $563 |
| storage temp. | -20°C |
|---|---|
| form | buffered aqueous solution |
| biological source | human |
| FDA UNII | E3T1VPO6RG |
| UNSPSC Code | 12352204 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Safety Statements | 23-24/25 |
|---|---|
| WGK Germany | 1 |
| Storage Class | 11 - Combustible Solids |
FURIN price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP6274 | Furin human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) | 10μg | $674 | 2026-04-30 | Buy | |
| Sigma-Aldrich | F2677 | Furin human ≥2,000?unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells | 141760-45-4 | 50units | $504 | 2026-04-30 | Buy |
| Usbiological | 563092 | FURIN PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy | |
| Usbiological | 563092 | FURIN PurifiedbyProteinGaffinitychromatography. | 100ug | $708 | 2026-06-03 | Buy | |
| Usbiological | 546980 | Furin PurifiedbyProteinAandpeptideaffinitychromatography. | 200ul | $563 | 2026-06-03 | Buy |
FURIN Chemical Properties,Uses,Production
Uses
Furin is capable of cleaving precursors of a wide variety of proteins, including growth factors, serum proteins, including proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins, typically at sites marked by the consensus sequence Arg-Xaa-(Lys/Arg)-Arg.
General Description
Furin also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg′). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.
Biochem/physiol Actions
Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It has a molecular mass of 52.7 kDa. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells. Furin cleaves precursor proteins at their paired basic amino acid processing sites. Some substrates of furin include von Willebrand factor, transforming growth factor beta 1 precursor, pro-beta-secretase and proparathyroid hormone.
Description
FURIN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 645 amino acids (108-715 a.a) and having a molecular mass of 69.8kDa. FURIN is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Furin is a member of the peptidase S8 family. Furin signifies the ubiquitous endoprotease activity within constitutive secretory pathways as well as capable of cleavage at the RX (K/R) R consensus motif. Furin is considered to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 as well as gp140 and might take part in tumor progression. Among the diseases associated with FURIN are dementia, familial british and plague.
FURIN Preparation Products And Raw materials
Raw materials
Preparation Products
FURIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4785 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4696 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9865 | 58 |
| ACROBiosystems | 13121935750 | jiaxin.zhao@acrobiosystems.com | China | 1520 | 58 |
| Enzo Biochem Inc | -- | Enzoname@qq.com | China | 6174 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Signalway Antibody LLC | -- | info@sabbiotech.com | China | 6243 | 58 |
| Supplier | Advantage |
|---|---|
| Creative Enzymes | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 55 |
| Sigma-Aldrich | 80 |
| Guangzhou Tomums Life Science Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| Biolab Reagents | 58 |
| ACROBiosystems | 58 |
| Enzo Biochem Inc | 58 |
| Merck KGaA | 58 |
| Signalway Antibody LLC | 58 |
