Ethyl trans-4-Hydroxycyclohexanecarboxylate
- CAS No.
- 3618-04-0
- Chemical Name:
- Ethyl trans-4-Hydroxycyclohexanecarboxylate
- Synonyms
- ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate;3618-04-0, 75877-66-6, 17159-80-7;3618-04-0, 17159-80-7, 75877-66-6;trans-Ethyl 4-hydroxycyclohexanecarboxylate;Ethyl trans-4-Hydroxycyclohexanecarboxylate;(1R,4R)-ethyl 4-hydroxycyclohexanecarboxylate;Ethyltrans-4-Hydroxycyclohexanecarboxylate>Ethyl trans-4-hydroxycyclohexane-1-carboxylate;4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER;(Trans)-ethyl 4-hydroxycyclohexane-1-carboxylate
- CBNumber:
- CB92130041
- Molecular Formula:
- C9H16O3
- Molecular Weight:
- 172.22
- MDL Number:
- MFCD16295187
- MOL File:
- 3618-04-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl trans-4-Hydroxycyclohexanecarboxylate >98.0%(GC) | E0838 | 5g | $230 |
| Ethyl trans-4-Hydroxycyclohexanecarboxylate >98.0%(GC) | E0838 | 25g | $575 |
| Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | OR939383 | 5g | $21 |
| Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | OR939383 | 25g | $36 |
| Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | OR939383 | 100g | $137 |
| More product size | |||
| Boiling point | 144°C/12mmHg(lit.) |
|---|---|
| Density | 1.093±0.06 g/cm3(Predicted) |
| refractive index | 1.4630 to 1.4670 |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| pka | 14.98±0.40(Predicted) |
| color | Colorless to Almost colorless |
| InChI | InChI=1S/C9H16O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h7-8,10H,2-6H2,1H3/t7-,8- |
| InChIKey | BZKQJSLASWRDNE-ZKCHVHJHSA-N |
| SMILES | [C@@H]1(C(OCC)=O)CC[C@@H](O)CC1 |
| FDA UNII | DYE45Z9SRP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918199890 |
Ethyl trans-4-Hydroxycyclohexanecarboxylate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0838 | Ethyl trans-4-Hydroxycyclohexanecarboxylate >98.0%(GC) | 3618-04-0 | 5g | $230 | 2026-04-30 | Buy |
| TCI Chemical | E0838 | Ethyl trans-4-Hydroxycyclohexanecarboxylate >98.0%(GC) | 3618-04-0 | 25g | $575 | 2026-04-30 | Buy |
| Apolloscientific | OR939383 | Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | 3618-04-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR939383 | Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | 3618-04-0 | 25g | $36 | 2026-06-04 | Buy |
| Apolloscientific | OR939383 | Ethyl trans-4-hydroxycyclohexanecarboxylate >98% | 3618-04-0 | 100g | $137 | 2026-06-04 | Buy |
Ethyl trans-4-Hydroxycyclohexanecarboxylate Chemical Properties,Uses,Production
Uses
trans-Ethyl 4-hydroxycyclohexanecarboxylate acts as a reagent in the discovery of Mer kinase inhibitors for the treatment of pediatric acute lymphoblastic leukemia, in the structural activity relationship study of piperidine-based derivatives as novel influenza virus inhibitors.
Synthesis
17159-79-4
3618-04-0
To a solution of ethyl 4-oxocyclohexanecarboxylate (13.5 g, 79 mmol) in methanol (150 mL) at 0 °C was slowly added sodium borohydride (5.3 g, 140 mmol). The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) followed by extraction with ethyl acetate (150 mL x 1, 50 mL x 2). The organic phases were combined, washed with water (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: hexane-ethyl acetate 1.5:1 to 1:1) to afford ethyl trans-4-hydroxycyclohexanecarboxylate (12 g, 88% yield, cis-trans ratio = 3:7) as a colorless transparent oil.1H NMR (300 MHz, CDCl3, cis-trans mixture) δ: 4.17-4.08 (m, 2H), 3.90 ( bs, 0.3H), 3.68-3.57 (m, 0.7H), 2.42-1.28 (m, 9H), 1.27-1.22 (m, 3H) ppm.(Hydroxyl signal was not observed.)
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[2] Organic Process Research and Development, 2010, vol. 14, # 4, p. 883 - 889
[3] Patent: WO2005/80317, 2005, A2. Location in patent: Page/Page column 150
[4] Tetrahedron Letters, 2000, vol. 41, # 39, p. 7567 - 7570
[5] Patent: US5175290, 1992, A
Ethyl trans-4-Hydroxycyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Pharmahands (Taizhou) Co., Ltd. | +86 523-86200360 | CHINA | 358 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from Ethyl trans-4-Hydroxycyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2024-07-12 | 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-04-08 | 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
|
1g | 99% | 200KG/MONTH | Pharmahands (Taizhou) Co., Ltd. |
-
- 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
3618-04-0
- 99%
- Pharmahands (Taizhou) Co., Ltd.
