5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
- CAS No.
- 376584-62-2
- Chemical Name:
- 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
- Synonyms
- 1-Oxoisoindolin-5-ylboronic acid pinacol ester;1-Isoindolinone-5-boronic acid pinacol ester;1-Isoindolinone-5-boronicacidpinacolester,96%;1-Oxoisoindoline-5-boronic acid, pinacol ester;1-Oxo-2,3-dihydro-isoindole-5-boronic acid picol ester;1-Oxo-2,3-dihydro-isoindole-5-boronic acid pinacol ester;2,3-Dihydro-1H-isoindol-1-one-5-boronic acid pinacol ester;5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ON;5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone
- CBNumber:
- CB92455302
- Molecular Formula:
- C14H18BNO3
- Molecular Weight:
- 259.11
- MDL Number:
- MFCD11040393
- MOL File:
- 376584-62-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone | CDS023371 | 50 mg | $230 |
| 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | FT142017 | 1g | $900 |
| 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | FT142017 | 0.5g | $900 |
| 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | FT142017 | 0.25g | $900 |
| 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | FT142017 | 0.1g | $900 |
| More product size | |||
| Boiling point | 476.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.16±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 13.95±0.20(Predicted) |
| Appearance | Off-white to light yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | 1S/C14H18BNO3/c1-13(2)14(3,4)19-15(18-13)10-5-6-11-9(7-10)8-16-12(11)17/h5-7H,8H2,1-4H3,(H,16,17) |
| InChIKey | CLACMCLRELMFLJ-UHFFFAOYSA-N |
| SMILES | CC1(OB(C2=CC=C3C(NCC3=C2)=O)OC1(C)C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS023371 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone | 50 mg | $230 | 2026-04-30 | Buy | |
| Biosynth | FT142017 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 376584-62-2 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | FT142017 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 376584-62-2 | 0.5g | $900 | 2026-06-04 | Buy |
| Biosynth | FT142017 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 376584-62-2 | 0.25g | $900 | 2026-06-04 | Buy |
| Biosynth | FT142017 | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 376584-62-2 | 0.1g | $900 | 2026-06-04 | Buy |
5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE Chemical Properties,Uses,Production
Uses
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one is a useful synthetic compound.
Synthesis
552330-86-6
73183-34-3
376584-62-2
General procedure for the synthesis of 1-isoindolone-5-boronic acid pinacol ester from 5-bromo-2,3-dihydroisoindol-1-one and bipinacol ester: to an anhydrous solution of 5-bromo-2,3-dihydroisoindol-1-one (1 eq.) of dioxane (0.1 M) were added bis(pinacol) diboron (1.1 eq.), potassium acetate (3.5 eq.) and 1,1'-bis(diphenylphosphine ) ferrocene (dppf, 0.05 eq.). The reaction mixture was degassed with nitrogen for 20 minutes. Subsequently, dichloro(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) (PdCl2(dppf), 0.05 eq.) was added and the mixture was degassed again for 5 minutes. Under nitrogen protection, the reaction mixture was heated to 70 °C for 2 hours and then warmed to 120 °C to continue the reaction for 16 hours. After completion of the reaction, the mixture was partitioned between ethyl acetate (EtOAc) and water. The aqueous phase was further extracted with ethyl acetate, the organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The residue was dissolved in dichloromethane (CH2Cl2) and hexane was added to precipitate the product. The resulting suspension was filtered and the brown powder was collected and dried and used without further purification. The yield of the product 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydroisoindol-1-one was 94% and purity was 76% with boric acid (13%) as the major impurity. Mass spectrometry analysis (LC-MS, ESP): m/z 260.4 [2M+H]+, retention time (R/T) = 3.51 min.
References
[1] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 121-122
[2] Patent: WO2016/161145, 2016, A1. Location in patent: Paragraph 00746
[3] Patent: WO2016/180536, 2016, A1. Location in patent: Page/Page column 199
[4] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 28-29
[5] Patent: WO2007/131991, 2007, A1. Location in patent: Page/Page column 91
5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28509 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9067 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2021-07-13 | 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLIN-1-ONE
376584-62-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
