ICA 069673
- CAS No.
- 582323-16-8
- Chemical Name:
- ICA 069673
- Synonyms
- ICA 069673;ICA 069673 ，S0144;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);ICA-069673, 10 mM in DMSO;N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
- CBNumber:
- CB92552603
- Molecular Formula:
- C11H6ClF2N3O
- Molecular Weight:
- 269.63
- MDL Number:
- MFCD20926351
- MOL File:
- 582323-16-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ICA 069673 ≥98% | 22995 | 5mg | $105 |
| ICA 069673 ≥98% | 22995 | 10mg | $184 |
| ICA 069673 ≥98% | 22995 | 25mg | $400 |
| ICA 069673 ≥98% | 22995 | 50mg | $796 |
| ICA 069673 ≥98% | 22995 | 5mg | $95 |
| More product size | |||
| Boiling point | 358.9±37.0 °C(Predicted) |
|---|---|
| Density | 1.539±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility |
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM) DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM) Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) |
| form | Powder |
| pka | 9.47±0.70(Predicted) |
| color | White to off-white |
| InChI | 1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18) |
| InChIKey | IIBSHMFXVWTQSJ-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC=C(F)C(F)=C1)NC2=CN=C(Cl)N=C2 |
| FDA UNII | NCO5DC74G8 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ICA 069673 price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 5mg | $105 | 2026-04-30 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 10mg | $184 | 2026-04-30 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 25mg | $400 | 2026-04-30 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 50mg | $796 | 2026-04-30 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 5mg | $95 | 2024-03-01 | Buy |
ICA 069673 Chemical Properties,Uses,Production
Description
ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.
Uses
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2].
storage
Room temperature
References
[1] Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. DOI:10.1124/jpet.115.225268
ICA 069673 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9946 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
