1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- CAS No.
- 279255-90-2
- Chemical Name:
- 1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- Synonyms
- (1-Boc-5-indolyl)methanol;1-Boc-1H-indol-5-ylmethanol;tert-butyl 5-(hydroxymethyl)indole-1-carboxylate;5-methylolindole-1-carboxylic acid tert-butyl ester;5-Hydroxymethyl-indole-1-carboxylic acid tert-butyl ester;5-(hydroxymethyl)-1-indolecarboxylic acid tert-butyl ester;1,1-Dimethylethyl 5-(hydroxymethyl)-1H-indole-1-carboxylate;1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl;1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester
- CBNumber:
- CB92553963
- Molecular Formula:
- C14H17NO3
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD09834884
- MOL File:
- 279255-90-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate 95% | OR305230 | 250mg | $160 |
| tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate 95% | OR305230 | 1g | $294 |
| tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 302043 | 250.00mg | $148 |
| tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 302043 | 1.00g | $271 |
| tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 302043 | 5.00g | $970 |
| More product size | |||
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR305230 | tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate 95% | 279255-90-2 | 250mg | $160 | 2026-06-04 | Buy |
| Apolloscientific | OR305230 | tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate 95% | 279255-90-2 | 1g | $294 | 2026-06-04 | Buy |
| Matrix Scientific | 302043 | tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 279255-90-2 | 250.00mg | $148 | 2026-05-19 | Buy |
| Matrix Scientific | 302043 | tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 279255-90-2 | 1.00g | $271 | 2026-05-19 | Buy |
| Matrix Scientific | 302043 | tert-Butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate | 279255-90-2 | 5.00g | $970 | 2026-05-19 | Buy |
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Chemical Properties,Uses,Production
Synthesis
279256-09-6
279255-90-2
General procedure for the synthesis of tert-butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate from tert-butyl 5-formyl-1H-indole-1-carboxylate: firstly, tert-butyl 5-formyl-1H-indole-1-carboxylate (12.23 mmol) was dissolved in methanol (30 mL) to obtain a solution. To this solution, sodium tetrahydroborate (0.463 g, 12.23 mmol) was slowly added at 0 °C. The reaction mixture was stirred continuously at 0 °C for 3 h, followed by stirring at room temperature overnight. After completion of the reaction, the resulting solution was diluted with water (40 mL) and extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, washed sequentially with aqueous sodium carbonate and brine, dried over anhydrous sodium sulfate, and concentrated in vacuum to afford tert-butyl 5-(hydroxymethyl)-1H-indole-1-carboxylate (2.5 g, 10.11 mmol, 83% yield) as a yellow oil.LCMS analysis showed m/z = 270.3 [M + Na]+.
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 20, p. 6847 - 6850
[2] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 955
1H-Indole-1-carboxylic acid, 5-(hydroxyMethyl)-, 1,1-diMethylethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +8618913958656 | inquiries@moldeep.com | China | 19983 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16027 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 2717 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 52678 | 58 |
| Shanghai Medicil Biomedical Co., Ltd. | 021-50822001 | marketing@medicilon.com.cn | China | 1152 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
