5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
- CAS No.
- 16078-71-0
- Chemical Name:
- 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
- Synonyms
- ETHYL 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE;AKOS 231-01;AKOS B000506;AKOS NCG-0076;BUTTPARK 19\09-73;AKOS BBS-00002940;5-AMno-4-carbethoxy-1-phenylpyrazole;5-amino-4-carboethoxy-1-phenylyrazole;3-AMINO-4-CARBETHOXY-2-PHENYLPYRAZOLE;5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
- CBNumber:
- CB9270345
- Molecular Formula:
- C12H13N3O2
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD00020731
- MOL File:
- 16078-71-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate 98% | 379441 | 5g | $85.8 |
| Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC) | E1258 | 1g | $115 |
| Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC) | E1258 | 5g | $461 |
| Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported | 275610 | 5g | $333 |
| Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported | 275610 | 10g | $475 |
| More product size | |||
| Melting point | 98-100 °C (lit.) |
|---|---|
| Boiling point | 373.33°C (rough estimate) |
| Density | 1.1818 (rough estimate) |
| refractive index | 1.5290 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | methanol: soluble25mg/mL, clear, colorless |
| form | powder to crystal |
| pka | 0.55±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| BRN | 211079 |
| InChI | InChI=1S/C12H13N3O2/c1-2-17-12(16)10-8-14-15(11(10)13)9-6-4-3-5-7-9/h3-8H,2,13H2,1H3 |
| InChIKey | AYJIUOZKKTUKKD-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=CC=C2)C(N)=C(C(OCC)=O)C=N1 |
| CAS DataBase Reference | 16078-71-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | TA5PP5LH2V |
| NIST Chemistry Reference | Ethyl 3-amino-2-phenylpyrazole-4-carboxylate(16078-71-0) |
| EPA Substance Registry System | 1H-Pyrazole-4-carboxylic acid, 5-amino-1-phenyl-, ethyl ester (16078-71-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-37/39-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ6392025 | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 379441 | Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate 98% | 16078-71-0 | 5g | $85.8 | 2023-06-20 | Buy |
| TCI Chemical | E1258 | Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC) | 16078-71-0 | 1g | $115 | 2026-04-30 | Buy |
| TCI Chemical | E1258 | Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC) | 16078-71-0 | 5g | $461 | 2026-04-30 | Buy |
| Usbiological | 275610 | Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported | 16078-71-0 | 5g | $333 | 2026-06-03 | Buy |
| Usbiological | 275610 | Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported | 16078-71-0 | 10g | $475 | 2026-06-03 | Buy |
5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline flakes
Uses
Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate may be used as internal standard for the GC-MS determination of etomidate [ethyl-1-(1-phenylethyl)-1H-imidazole-5-carboxylate] in mouse brain tissue.
General Description
Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate is a heterocyclic building block.
Synthesis
100-63-0
94-05-3
16078-71-0
General procedure for the synthesis of ethyl 5-amino-1-phenylpyrazole-4-carboxylate from phenylhydrazine and ethyl ethoxymethylcyanoacetate: ethyl 2-cyano-3-ethoxyacrylate (1.5 g, 8.9 mmol, 1.0 equiv.) was dissolved in ethanol (10 mL), followed by the addition of N,N-diisopropylethylamine (0.74 mL, 9.8 mmol, 1.1 equiv.) and phenylhydrazine (0.96 mL, 9.8 mmol, 1.1 equiv.). The reaction mixture was heated to 85 °C and stirred for 12 hours. Upon completion of the reaction, the mixture was concentrated to dryness and the residue was dissolved in a minimal amount of dichloromethane and purified by silica gel column chromatography (eluent: 20-30% ethyl acetate in hexane solution) to afford ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (2.0 g, 96% yield) as an orange solid.MS (EI) m/z: 232 [M + H]+.
References
[1] Patent: WO2016/49500, 2016, A1. Location in patent: Paragraph 00217
[2] Cell Chemical Biology, 2018,
[3] Organic Letters, 2013, vol. 15, # 19, p. 5044 - 5047
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4428 - 4433
[5] Tetrahedron, 2017, vol. 73, # 40, p. 5959 - 5973
5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
View Lastest Price from 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
16078-71-0
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
16078-71-0
- $1.00
- 99%
- Career Henan Chemical Co
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