Lefamulin
- CAS No.
- 1061337-51-6
- Chemical Name:
- Lefamulin
- Synonyms
- 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;BC 3781;Lefamulin;Lefamulin(BC-3781);Lefamulin, 10 mM in DMSO;(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate;Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- CBNumber:
- CB93039318
- Molecular Formula:
- C28H45NO5S
- Molecular Weight:
- 507.73
- MDL Number:
- MFCD28963989
- MOL File:
- 1061337-51-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Lefamulin ≥98% (HPLC), powder | SBR00096 | 5 mg | $79.9 |
| Lefamulin ≥98% (HPLC), powder | SBR00096 | 1 unit | $68.55 |
| Lefamulin ≥95% | 36285 | 5mg | $110 |
| Lefamulin ≥95% | 36285 | 10mg | $156 |
| Lefamulin ≥95% | 36285 | 25mg | $330 |
| Boiling point | 618.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 16 mg/mL; DMSO: 12 mg/mL; Ethanol: 3 mg/mL; PBS (pH 7.2): 0.25 mg/mL |
| form | A solid |
| pka | 14.45±0.60(Predicted) |
| color | White to off-white |
| InChIKey | KPVIXBKIJXZQJX-FCEONZPQSA-N |
| SMILES | C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@]2([H])C(=O)CC3)(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O |
| FDA UNII | 21904A5386 |
| ATC code | J01XX12 |
| UNSPSC Code | 51101500 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H411 |
| Precautionary statements | P260-P264-P270-P308+P311-P405-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | STOT SE 2 |
| REACH Registrations | Active |
Lefamulin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00096 | Lefamulin ≥98% (HPLC), powder | 1061337-51-6 | 5 mg | $79.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | SBR00096 | Lefamulin ≥98% (HPLC), powder | 1061337-51-6 | 1 unit | $68.55 | 2025-07-31 | Buy |
| Cayman Chemical | 36285 | Lefamulin ≥95% | 1061337-51-6 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 36285 | Lefamulin ≥95% | 1061337-51-6 | 10mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 36285 | Lefamulin ≥95% | 1061337-51-6 | 25mg | $330 | 2026-04-30 | Buy |
Lefamulin Chemical Properties,Uses,Production
Uses
Lefamulin is an antibiotic medication used in the treatment of adults with community-acquired bacterial pneumonia.
Biological Activity
Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.
Synthesis
synthesis route of Lefamulin
in vivo
Lefamulin (10-140 mg/kg, s.c.) shows anti-inflammatory effect on LPS-induced lung neutrophilia mouse model[4].
Lefamulin (1.25-160 mg/kg, s.c.) shows antibacterial effect in S. pneumoniae or S. aureus challenged lung infection mice[5].
| Animal Model: | LPS-induced lung neutrophilia mouse model[4] |
| Dosage: | 10-140 mg/kg |
| Administration: | Subcutaneous injection (s.c.) |
| Result: | Reduced BALF neutrophil cell counts. Reduced pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, and GM-CSF), chemokine (CXCL-1, CXCL-2, and CCL-2) and MMP-9 levels in mouse lung tissue. |
Lefamulin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Lefamulin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3016 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28291 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
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