2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- CAS No.
- 445264-61-9
- Chemical Name:
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Synonyms
- 2-methoxyl-5-pyridineboronic acid pinacol ester;2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-(-2-Methoxypyridin-5-yl) Pyridine;2-Methoxypyridine-5-boronic acid pinacoL;6-Methoxy-pyridine-3-boronic acid picol ester;6-Methoxy-3-pyridylboronic Acid Pinacol Ester;2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER;6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER;(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester
- CBNumber:
- CB9367724
- Molecular Formula:
- C12H18BNO3
- Molecular Weight:
- 235.09
- MDL Number:
- MFCD05663858
- MOL File:
- 445264-61-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Methoxypyridine-5-boronic acid pinacol ester 97% | 636029 | 1g | $32 |
| 2-Methoxypyridine-5-boronic acid pinacol ester 97% | 636029 | 5g | $152 |
| 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T) | M2650 | 1g | $35 |
| 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T) | M2650 | 5g | $139 |
| (2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester | 159675 | 1g | $418 |
| More product size | |||
| Melting point | 47-51 °C(lit.) |
|---|---|
| Boiling point | 102°C/0.08mmHg(lit.) |
| Density | 1.06±0.1 g/cm3(Predicted) |
| Flash point | 216 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Water Solubility | Soluble in water |
| form | powder to crystal |
| pka | 3.39±0.12(Predicted) |
| color | White to Almost white |
| InChI | 1S/C12H18BNO3/c1-11(2)12(3,4)17-13(16-11)9-6-7-10(15-5)14-8-9/h6-8H,1-5H3 |
| InChIKey | QOGNDJLSYMJGPP-UHFFFAOYSA-N |
| SMILES | COc1ccc(cn1)B2OC(C)(C)C(C)(C)O2 |
| CAS DataBase Reference | 445264-61-9(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 636029 | 2-Methoxypyridine-5-boronic acid pinacol ester 97% | 445264-61-9 | 1g | $32 | 2023-06-20 | Buy |
| Sigma-Aldrich | 636029 | 2-Methoxypyridine-5-boronic acid pinacol ester 97% | 445264-61-9 | 5g | $152 | 2023-01-07 | Buy |
| TCI Chemical | M2650 | 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T) | 445264-61-9 | 1g | $35 | 2026-04-30 | Buy |
| TCI Chemical | M2650 | 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T) | 445264-61-9 | 5g | $139 | 2026-04-30 | Buy |
| Usbiological | 159675 | (2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester | 445264-61-9 | 1g | $418 | 2026-06-03 | Buy |
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Uses,Production
Uses
(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.
Uses
2-Methoxypyridine-5-boronic acid pinacol ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.
Synthesis
13472-85-0
73183-34-3
445264-61-9
Step 1: 5-bromo-2-methoxypyridine (55 g, 0.29 mol), pinacol ester of bisboronic acid (90 g, 0.35 mol), potassium acetate (57 g, 0.58 mol) and bis(triphenylphosphine)palladium(II) chloride (2.2 g, 3 mmol) were dissolved in anhydrous dioxane (500 mL) under nitrogen protection. The reaction mixture was heated and stirred at 108 °C overnight. Upon completion of the reaction, the mixture was concentrated and purified by column chromatography using hexane/ethyl acetate as eluent to afford pinacol ester of 6-methoxypyridine-3-boronic acid (58 g, 84% yield).
References
[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 36
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 151
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 12, p. 2496 - 2500
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6477 - 6485
2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-05 | 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-11-18 | 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-13 | 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
- $0.00
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
