4-Fluoro-2-methoxyphenylboronic acid
- CAS No.
- 179899-07-1
- Chemical Name:
- 4-Fluoro-2-methoxyphenylboronic acid
- Synonyms
- AKOS BRN-0234;5-Fluoroanisole-2-boronic acid;4-Fluoro-2-Methoxyphenylboroni;4-FLUORO-2-FORMYLPHENYLBORONIC ACID;2-METHOXY-4-FLUOROPHENYLBORONIC ACID;4-FLUORO-2-METHOXYPHENYLBORONIC ACID;4-FLUORO-2-METHOXYBENZENEBORONIC ACID;B-(4-Fluoro-2-methoxyphenyl)boronic acid;4-fluoro-2-methoxyphenylboronic acid 98%;BORONIC ACID,B-(4-FLUORO-2-METHOXYPHENYL)-
- CBNumber:
- CB9379998
- Molecular Formula:
- C7H8BFO3
- Molecular Weight:
- 169.95
- MDL Number:
- MFCD03788423
- MOL File:
- 179899-07-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluoro-2-methoxyphenylboronic acid ≥95% | 564494 | 5g | $83.4 |
| 4-Fluoro-2-methoxyphenylboronic acid ≥95% | 564494 | 1g | $33 |
| 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | F1062 | 1g | $93 |
| 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | F1062 | 5g | $368 |
| 4-Fluoro-2-methoxybenzeneboronic acid >98% | PC11112 | 1g | $21 |
| More product size | |||
| Melting point | 131-136 °C (lit.) |
|---|---|
| Boiling point | 294.8±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Crystalline Powder |
| pka | 8.69±0.58(Predicted) |
| color | White |
| InChI | InChI=1S/C7H8BFO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3 |
| InChIKey | ADJBXDCXYMCCAD-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(F)C=C1OC)(O)O |
| CAS DataBase Reference | 179899-07-1(CAS DataBase Reference) |
| FDA UNII | YX7R999XR8 |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36-60-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
4-Fluoro-2-methoxyphenylboronic acid price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 564494 | 4-Fluoro-2-methoxyphenylboronic acid ≥95% | 179899-07-1 | 5g | $83.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 564494 | 4-Fluoro-2-methoxyphenylboronic acid ≥95% | 179899-07-1 | 1g | $33 | 2023-06-20 | Buy |
| TCI Chemical | F1062 | 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 179899-07-1 | 1g | $93 | 2026-04-30 | Buy |
| TCI Chemical | F1062 | 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 179899-07-1 | 5g | $368 | 2026-04-30 | Buy |
| Apolloscientific | PC11112 | 4-Fluoro-2-methoxybenzeneboronic acid >98% | 179899-07-1 | 1g | $21 | 2026-06-04 | Buy |
4-Fluoro-2-methoxyphenylboronic acid Chemical Properties,Uses,Production
Uses
suzuki reaction
Uses
Reactant involved in:
Suzuki-Miyaura cross-coupling reactions for synthesis of heterobiaryls
Suzuki and Still coupling for synthesis of antithrombotic drugs
Reactant / precursor used for the synthesis of biologically active molecules including:
2-(4-pyridyl)thienopyridinones for use as GSK-3β inhibitors
Arylheteroarylmethylamines as NR2B subtype of NMDA receptor antagonists with antidepressant activity
Biphenylketones for use as dual modulators of inflammation and bone loss
CB1 antagonists
Synthesis
121-43-7
450-88-4
179899-07-1
4-Fluoro-2-methoxyphenylboronic acid was synthesized as follows: 2-bromo-5-fluoroanisole (5.9 g, 29 mmol) and anhydrous tetrahydrofuran (50 mL) were added to a dry round-bottomed flask under argon protection. After cooling the reaction system to -78°C, n-butyllithium (17.4 mL, 43.5 mmol) was added slowly and dropwise. After stirring the reaction at -78°C for 30 minutes, trimethyl borate (4.9 mL, 43.5 mmol) was added, followed by a slow warming of the reaction mixture to room temperature (~1.3 hours). After completion of the reaction, the mixture was cooled to 0°C and acidified by adding 10% aqueous hydrochloric acid (20 mL). Tetrahydrofuran was removed by distillation under reduced pressure and saturated saline (50 mL) was added. The aqueous phase was extracted twice with ether. The organic phases were combined and washed sequentially with 10% aqueous hydrochloric acid and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellow solid product 4-fluoro-2-methoxyphenylboronic acid (4 g, 82% yield). The product was characterized by 1H NMR (400 MHz, acetone-d6): δ 7.84 (t, 1H, J = 8 Hz, C6-H), 6.85 (dd, 1H, J = 12.2 Hz, C3-H), 6.76 (td, 1H, J = 8, 2 Hz, C5-H).
References
[1] Patent: US2004/6134, 2004, A1
4-Fluoro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 4-Fluoro-2-methoxyphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
|
$1.00 | 1KG | 97%-99% | 1kg;5kg;100kg | Career Henan Chemical Co |
-
- 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Fluoro-2-methoxyphenylboronic acid
179899-07-1
- $1.00
- 97%-99%
- Career Henan Chemical Co
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