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ChemicalBook >> CAS DataBase List >>WITHAFERIN A

WITHAFERIN A

CAS No.
5119-48-2
Chemical Name:
WITHAFERIN A
Synonyms
(4beta,5beta,6beta,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione;NSC 273757;nsc-101088;upeferinA.;Withaferine;WITHAFERIN A;withaferinea;Withaferin A-RM;Withaferin A (WFA);Withaferin A Standard
CBNumber:
CB9454365
Molecular Formula:
C28H38O6
Molecular Weight:
470.6
MDL Number:
MFCD10687098
MOL File:
5119-48-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Withaferin A phyproof? Reference Substance PHL89824 10MG $633
Withaferin A 681535 1mg $166
Withaferin A 681535 5mg $556
Withaferin A ≥95% 11352 1mg $90
Withaferin A ≥95% 11352 5mg $262
More product size

WITHAFERIN A Properties

Melting point 252-253℃
alpha D28 +125° (c = 1.30 in CHCl3)
Boiling point 680.7±55.0 °C(Predicted)
Density 1.28
Flash point 226℃
storage temp. Desiccate at -20°C
solubility Soluble in DMSO (up to 20 mg/ml)
pka 13.49±0.70(Predicted)
form White solid
color White
biological source plant (Withania somnifera)
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Major Application food and beverages
InChIKey DBRXOUCRJQVYJQ-CKNDUULBSA-N
SMILES C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C
FDA UNII L6DO3QW4K5
UNSPSC Code 85151701
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  T
WGK Germany  3
RTECS  KE7288500
HS Code  29322090
Storage Class 11 - Combustible Solids

WITHAFERIN A price More Price(113)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL89824 Withaferin A phyproof? Reference Substance 5119-48-2 10MG $633 2026-04-30 Buy
Sigma-Aldrich 681535 Withaferin A 5119-48-2 1mg $166 2026-04-30 Buy
Sigma-Aldrich 681535 Withaferin A 5119-48-2 5mg $556 2026-04-30 Buy
Cayman Chemical 11352 Withaferin A ≥95% 5119-48-2 1mg $90 2026-04-30 Buy
Cayman Chemical 11352 Withaferin A ≥95% 5119-48-2 5mg $262 2026-04-30 Buy
Product number Packaging Price Buy
PHL89824 10MG $633 Buy
681535 1mg $166 Buy
681535 5mg $556 Buy
11352 1mg $90 Buy
11352 5mg $262 Buy

WITHAFERIN A Chemical Properties,Uses,Production

Description

Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro(IC50= 12 nM) andin vivo.1Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2Covalently binds to the intermediate filament protein, vimentin3inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis inin vivomodels.5

Chemical Properties

Solid

Uses

Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).

Definition

ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.

Biological Activity

Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.

target

ROS | NF-kB | p53 | STAT | PARP | Bcl-2/Bax | Caspase | TGF-β/Smad | TNF-α | COX | PGE | PI3K | Akt | JNK | p38MAPK

storage

Store at -20°C

References

[1] ROYCE MOHAN. Withaferin A is a potent inhibitor of angiogenesis[J]. Angiogenesis, 2004, 7 2: 115-122. DOI:10.1007/s10456-004-1026-3
[2] MARY KAILEH. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.[J]. The Journal of Biological Chemistry, 2007, 282 7: 4253-4264. DOI:10.1074/jbc.m606728200
[3] PAOLA BARGAGNA-MOHAN. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin.[J]. Chemistry & biology, 2007, 14 6: 623-634. DOI:10.1016/j.chembiol.2007.04.010
[4] JOSE T. THAIPARAMBIL. Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation[J]. International Journal of Cancer, 2011, 129 11: 2744-2755. DOI:10.1002/ijc.25938
[5] IZHAR LIVNE-BAR. Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis[J]. Cell Death & Disease, 2016, 7 9: e2386-e2386. DOI:10.1038/cddis.2016.277

1159096-16-8
5119-48-2
Synthesis of WITHAFERIN A from 2,3-dihydro-3beta-O-sulfate withaferin A

WITHAFERIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 189)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3957 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 480 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +86-18080483897 sales@biopurify.com China 4616 58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		+8613815430202 sale02@cqherb.com CHINA 376 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32468 58
Hubei Ipure Biology Co., Ltd 		+8618062405514 ada@ipurechemical.com China 10236 58

View Lastest Price from WITHAFERIN A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WITHAFERIN A pictures 2026-07-15 WITHAFERIN A
5119-48-2
 $77.00-392.00 99.99% 10g TargetMol Chemicals Inc.
WITHAFERIN A pictures 2026-06-30 WITHAFERIN A
5119-48-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
WITHAFERIN A pictures 2026-06-18 WITHAFERIN A
5119-48-2
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
  • WITHAFERIN A pictures
  • WITHAFERIN A
    5119-48-2
  • $77.00-392.00
  • 99.99%
  • TargetMol Chemicals Inc.
  • WITHAFERIN A pictures
  • WITHAFERIN A
    5119-48-2
  • $0.00
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd
  • WITHAFERIN A pictures
  • WITHAFERIN A
    5119-48-2
  • $1.00
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

WITHAFERIN A Spectrum

WITHAFERIN A 5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid delta-lactone,(20s,22r)-oxo nsc-101088 (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone NSC 273757 Withaferine (20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone Withaferin A NSC 273757 NSC 101088 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide withaferinea Withaferin A from leaves of Withania somnifera Ergosta-2,24-dien-26-oicacid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, d-lactone, (4b,5b,6b,22R)- Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem Withaferin A 5119-48-2 Withaferin A Standard Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)- AshwagandhaQ: What is Ashwagandha Q: What is the CAS Number of Ashwagandha Q: What is the storage condition of Ashwagandha upeferinA. (4S,4aR,5aR,6aS,6bS,9R,9aS,11aS,11bR)-4-Hydroxy-9-((S)-1-((R)-5-(hydroxymethyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-9a,11b-dimethyl-5a,6,6a,6b,7,8,9,9a,10,11,11a,11b-dodecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-1(4H)-one Withaferin A-RM Withaferin A from Withania somnifera WITHAFERIN A, 10 mM in DMSO Withaferin A, Withania somnifera Withaferin A (WFA) (1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-Hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one (4S,4a-R,5a-R,6a-S,6b-S,9R,9a-S,1a-S,1b-R)-4-hydroxy-9-((S)-1-((R)-5-(hydroxymethyl)-4-methyl-6-oxy-3,6-dihydro-2H-pyran-2-yl)ethyl)-9a,1bdimethyl-5a,6,6a,6b,7,8,9,9a,10,1,1a,1bdecadihydrocyclopentyl[1,2]phenanthrene[8a,9-b]oxy-1(4H)-one (4beta,5beta,6beta,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione 5119-48-2 Intermediates & Fine Chemicals Pharmaceuticals Steroids antibiotic
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