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ChemicalBook >> CAS DataBase List >>N-Ethyl-p-toluenesulfonamide

N-Ethyl-p-toluenesulfonamide

CAS No.
80-39-7
Chemical Name:
N-Ethyl-p-toluenesulfonamide
Synonyms
ETSM;N-E-PTSA;Unipex 108;Uniplex 108;Santicizer 3;Ncgc00091206-01;N-Tosylethylamine;N-Ethyl-p-toluenesul;Brinzolamide Impurity 1;Ethyl toluenesulfonamide
CBNumber:
CB9493133
Molecular Formula:
C9H13NO2S
Molecular Weight:
199.27
MDL Number:
MFCD00048511
MOL File:
80-39-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:39:39
Product description Number Pack Size Price
N-Ethyltoluene-4-sulfonamide for synthesis 8.43970 50 g $55.9
N-Ethyltoluene-4-sulfonamide for synthesis 8.43970 250 g $188
N-Ethyl-p-toluenesulfonamide >98.0%(HPLC)(N) E0674 25g $22
N-Ethyl-p-toluenesulfonamide >98.0%(HPLC)(N) E0674 500g $117
N-?Ethyl-?p-?toluenesulfonamide TRC-E932533-5G 5g $68
More product size

N-Ethyl-p-toluenesulfonamide Properties

Melting point 63-65 °C(lit.)
Boiling point 208 °C745 mm Hg(lit.)
Density 1.26 g/cm3
refractive index 1.5270 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 11.86±0.50(Predicted)
form Solid
color White to Off-White
Stability Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions FILM FORMING
PLASTICISER
InChI InChI=1S/C9H13NO2S/c1-3-10-13(11,12)9-6-4-8(2)5-7-9/h4-7,10H,3H2,1-2H3
InChIKey OHPZPBNDOVQJMH-UHFFFAOYSA-N
SMILES C1(S(NCC)(=O)=O)=CC=C(C)C=C1
LogP 1.960 (est)
Indirect Additives used in Food Contact Substances N-ETHYL-P-TOLUENESULFONAMIDE
CAS DataBase Reference 80-39-7(CAS DataBase Reference)
FDA 21 CFR 175.105
FDA UNII 992S798SJB
NIST Chemistry Reference 4-Toluenesulfonamide, n-ethyl-(80-39-7)
EPA Substance Registry System N-Ethyl-p-toluenesulfonamide (80-39-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37
WGK Germany  3
TSCA  TSCA listed
HS Code  29350090
Storage Class 13 - Non Combustible Solids
NFPA 704
1
0

N-Ethyl-p-toluenesulfonamide price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.43970 N-Ethyltoluene-4-sulfonamide for synthesis 80-39-7 50 g $55.9 2026-04-30 Buy
Sigma-Aldrich 8.43970 N-Ethyltoluene-4-sulfonamide for synthesis 80-39-7 250 g $188 2026-04-30 Buy
TCI Chemical E0674 N-Ethyl-p-toluenesulfonamide >98.0%(HPLC)(N) 80-39-7 25g $22 2026-04-30 Buy
TCI Chemical E0674 N-Ethyl-p-toluenesulfonamide >98.0%(HPLC)(N) 80-39-7 500g $117 2021-12-16 Buy
TRC TRC-E932533-5G N-?Ethyl-?p-?toluenesulfonamide 80-39-7 5g $68 2026-06-03 Buy
Product number Packaging Price Buy
8.43970 50 g $55.9 Buy
8.43970 250 g $188 Buy
E0674 25g $22 Buy
E0674 500g $117 Buy
TRC-E932533-5G 5g $68 Buy

N-Ethyl-p-toluenesulfonamide Chemical Properties,Uses,Production

Description

N-Ethyl-p-toluenesulfonamide (N-PTSA) is a white crystal commonly used as a pharmaceutical intermediate. It is synthesized by reacting ethyl acetoacetate with p-toluenesulfonyl chloride under alkaline conditions. In the pharmaceutical industry, N-PTSA is utilized in the synthesis of various drugs. The presence of ethyl and p-toluenesulfonamide groups in its structure makes N-PTSA valuable for specific applications in drug synthesis. Additionally, N-PTSA is employed as a plasticiser to enhance polymers more reactivity[1].

Chemical Properties

off-white crystalline solid

Uses

N-Ethyl-4-toluene sulfonamide is a resin carrier in dental materials used for isolating cavities below restorations; plasticizer in polyvinyl alcohollacquers, polyamides, cellulose acetate, etc.

Uses

Plasticizer.

Uses

N-Ethyl-p-toluenesulfonamide is a reagent used in the sulfonamidation of imidazopyridines.

General Description

Platelets (from dilute alcohol or ligroin) or off-white solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for N-Ethyl-p-toluenesulfonamide are not available; however, N-Ethyl-p-toluenesulfonamide is probably combustible.

References

[1] Xiao Bian . (2025). Solubility, solvent effects and thermodynamic properties of N-Ethyl-p-toluenesulfonamide in twelve pure organic solvents. Journal of the Taiwan Institute of Chemical Engineers, 170, Article 106009. https://doi.org/10.1016/j.jtice.2025.106009

N-Ethyl-p-toluenesulfonamide Preparation Products And Raw materials

Global( 248)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-17732866630 mina@chuanghaibio.com China 18126 58
Shaanxi Haibo Biotechnology Co., Ltd 		+86-18629295024 qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6366 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58

View Lastest Price from N-Ethyl-p-toluenesulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Ethyl-p-Toluenesulfonamide pictures 2026-07-09 N-Ethyl-p-Toluenesulfonamide
80-39-7
 $10.00 1KG 99% Henan Fengda Chemical Co., Ltd
N-Ethyl-p-Toluene Sulfonamide, NEPTSA, N-Ethyl-p-toluenesulfonamide pictures 2026-06-03 N-Ethyl-p-Toluene Sulfonamide, NEPTSA, N-Ethyl-p-toluenesulfonamide
80-39-7
 $5800.00 1KG 99% Min 200 tons per month Shouguang Nuomeng Chemical Co Ltd.
N-Ethyl-p-toluenesulfonamide pictures 2026-03-20 N-Ethyl-p-toluenesulfonamide
80-39-7
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Benzenesulfonamide, N-ethyl-4-methyl- Ethyl toluenesulfonamide Ethylp-toluenesulfonamide n-ethyl-4-methyl-benzenesulfonamid n-ethyl-4-methylbenzenesulfonamide N-Ethyl-4-methyl-benzenesulfonamide N-Ethyltoluene-4-sulfonamide for synthesis n-ethyl-4-toluenesulfonamide N-Ethyl-p-methylbenzenesulfonamide N-Ethyl-p-tolylsulfonamide N-Tosylethylamine p-Tolueneethylsulfonamide p-Toluenesulfonamide, N-ethyl- p-Toluenesulfonyl-N-ethylamide Santicizer 3 Unipex 108 Uniplex 108 ETSM p-Toluenesulfonylethylamide N-Ethyl Para Toluene Sulphonamide N-ETHYLTOLUENESULPHONAMIDE ETHYL-TOLUENESULPHONAMIDE N-ETHYL-4-METHYLBENZENESULPHONAMIDE N-ETHYL-4-TOLUENESULPHONAMIDE BENZENESULFONAMIDE,N-ETHYL- 4-Toluenesulfonic acid N-ethylamide N-E-PTSA N-ETHYL-TOLUENESULFONAMIDE N-ETHYL-P-TOLUENESULFONAMIDE N-Ethyltoluene-4-sulphonamide Ncgc00091206-01 N-Ethyl-p-toluenesul N-Ethyl-p-toluenesulfonamide 98% N-Ethyl-p-toluenesulfonamide, >=99% N-Ethyl-p-toluenesulfonamide N-Ethyl-p-toluenesulfonaMide,N-Ethyltoluene-4-sulphonaMide Brinzolamide Impurity 1 N-Ethyl-p-Toluene Sulfonamide, NEPTSA, N-Ethyl-p-toluenesulfonamide N-Ethyl-p-toluenesulfonamide> N-Ethyl-p-toluenesulfonamide ISO 9001：2015 REACH N-Ethyl-4-methylbenzenesulfonamide in Acetonitrile 3-Ethyl-4-methylbenzenesulfonamide N-Alkylp-toluenesulfonamide N-Ethyl-4-methylbenzenesulfonamide 100 μg/mL in Acetonitrile 80-39-7 Protected Amines Organic Building Blocks Nitrogen Compounds Building Blocks Nitrogen Compounds Organic Building Blocks Protected Amines
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