2-Methoxy-4-methylphenol
- CAS No.
- 93-51-6
- Chemical Name:
- 2-Methoxy-4-methylphenol
- Synonyms
- CREOSOL;4-METHYLGUAIACOL;4-Methyl-2-methoxyphenol;Phenol, 2-methoxy-4-methyl-;FEMA 2671;2-METHOXY-P-CRESOL;VALSPICE;METHYL GUAIACOL;p-Methylguaiacol;p-Creosol
- CBNumber:
- CB9667640
- Molecular Formula:
- C8H10O2
- Molecular Weight:
- 138.16
- MDL Number:
- MFCD00002378
- MOL File:
- 93-51-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Methoxy-4-methylphenol natural, 97%, FG | W267112 | 1 each | $62.3 |
| 2-Methoxy-4-methylphenol natural, 97%, FG | W267112 | 100g | $339 |
| 2-Methoxy-4-methylphenol ≥98%, FG | W267104 | 1 each | $58 |
| 2-Methoxy-4-methylphenol natural, 97%, FG | W267112 | 1kg | $1690 |
| 2-Methoxy-4-methylphenol ≥98%, FG | W267104 | 100g | $77.4 |
| More product size | |||
| Melting point | 5 °C (lit.) |
|---|---|
| Boiling point | 221-222 °C (lit.) |
| Density | 1.092 g/mL at 25 °C (lit.) |
| FEMA | 2671 | 2-METHOXY-4-METHYLPHENOL |
| refractive index |
n |
| FLAVIS Number | 04.007 | 2-Methoxy-4-methylphenol |
| Flash point | 211 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Liquid |
| pka | 10.27±0.18(Predicted) |
| Specific Gravity | 1.091.092 |
| color | colorless to light yellow |
| Odor | at 10.00 % in dipropylene glycol. spicy clove vanilla phenolic medicinal leathery woody smoky burnt |
| Odor Type | spicy |
| biological source | synthetic |
| Water Solubility | Slightly soluble in water. |
| Merck | 14,2571 |
| JECFA Number | 715 |
| BRN | 1862340 |
| Henry's Law Constant | 7.7×100 mol/(m3Pa) at 25℃, Sagebiel et al. (1992) |
| Dielectric constant | 11.0 |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C8H10O2/c1-6-3-4-7(9)8(5-6)10-2/h3-5,9H,1-2H3 |
| InChIKey | PETRWTHZSKVLRE-UHFFFAOYSA-N |
| SMILES | COc1cc(C)ccc1O |
| LogP | 1.65 |
| CAS DataBase Reference | 93-51-6(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 2-METHOXY-4-METHYLPHENOL |
| EWG's Food Scores | 1-2 |
| FDA UNII | W9GW1KZG6N |
| NIST Chemistry Reference | Phenol, 2-methoxy-4-methyl-(93-51-6) |
| EPA Substance Registry System | Phenol, 2-methoxy-4-methyl- (93-51-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GP1755000 | |||||||||
| F | 10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29095090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2-Methoxy-4-methylphenol price More Price(114)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W267112 | 2-Methoxy-4-methylphenol natural, 97%, FG | 93-51-6 | 1 each | $62.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | W267112 | 2-Methoxy-4-methylphenol natural, 97%, FG | 93-51-6 | 100g | $339 | 2026-04-30 | Buy |
| Sigma-Aldrich | W267104 | 2-Methoxy-4-methylphenol ≥98%, FG | 93-51-6 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W267112 | 2-Methoxy-4-methylphenol natural, 97%, FG | 93-51-6 | 1kg | $1690 | 2026-04-30 | Buy |
| Sigma-Aldrich | W267104 | 2-Methoxy-4-methylphenol ≥98%, FG | 93-51-6 | 100g | $77.4 | 2026-04-30 | Buy |
2-Methoxy-4-methylphenol Chemical Properties,Uses,Production
Description
2-Methoxy-4-methylphenol has a characteristic aromatic odor (sweet, spicy, slightly vanilla-like) and a somewhat bitter taste (vanilla-like). May be prepared by methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.
Chemical Properties
2-Methoxy-4-methylphenol is a clear colorless to slightly yellow liquid or viscous, yeelowish oil, solidifying in the cold. The prismatic crystals melt at 6° C. Sp.Gr. 1.10. B.P. 222° C. Very slightly soluble in water, soluble in alcohol and oils. Sweet-spicy, phenolic-leathery odor with distinctly Vanilla-1ike undertones, balsamicwarm sweetness, but overall too medicinal to become classified as a versatile, floral-balsamic ingredient.
Occurrence
Occurs in beechwood tar; also identified in the essential oils of ylang-ylang, jasmine and anise seeds; it is one of the active constituents of creosote. Reported found in Gruyere cheese, smoked fish, cured pork, beer, rum, bourbon whiskey, malt and Scotch whiskey, sherry, white and red wine, cocoa, coffee, tea, mushrooms, mango, pear brandy, malt, wort, dried bonito, Bourbon vanilla, cuttlefish and green maté.
Uses
2-Methoxy-4-methylphenol is used for blending baking and smoked food flavors. Excellent additive and modifier in artificial Ylang-Ylang, Cassie-bases, Jasmin bases, Lily, Gardenia, etc. Finds use in flavor compositions for imitation Vanilla, Clove, various fruit compositions, Rum flavors, etc. and in Nut-Nougat flavor bases. Concentration will be about 0.02 to 1 ppm in the finished consumer product. In beverages, however, it may be as high as 10 to 20 ppm.
Definition
ChEBI: 2-Methoxy-4-methylphenol is a member of phenols and a member of methoxybenzenes. It is used in preparation of renewable bis(cyanate) esters.
Preparation
By methylation of homopyrocatechin using dimethyl sulfate and alkali; also by hydrogenation of vanillin.
Production Methods
With three distinct oxygenated functional groups (aldehyde, ether, and hydroxyl), VAN can undergo selective hydrodeoxygenation to produce 2- methoxy-4-methylphenol (MMP), a promising candidate for future biofuel applications and its use in fragrances and intermediate in pharmaceutical synthesis. Kumar et al. developed stable, cost-effective Ni nanoparticles supported on montmorillonite (MMT) clay, which was synthesized for eco-friendly, alcohol-mediated catalytic transfer hydrodeoxygenation of VAN to MMP. The Ni(10%)/MMT catalyst achieved >99% VAN conversion and 95.2% MMP selectivity using isopropanol (IPA) as a solvent and hydrogen donor[1].
References
[1] Atul Kumar, Prof. Dr. Rajendra Srivastava, Dr. Rajaram Bal. “Ni Nanoparticles Supported Montmorillonite Clay for Selective Catalytic Transfer Hydrodeoxygenation of Vanillin into 2-Methoxy-4-methylphenol.” ChemCatChem 16 9 (2024).
Aroma threshold values
Detection: 90 ppb. Aroma characteristics at 1.0%: smoky, sweet, phenolic, vanilla, spicy clove with a floral carnation nuance.
Taste threshold values
Taste characteristics at 1.0 to 1.25 ppm: sweet phenolic, spice, vanilla, medicinal, clove-like, smoky, guaia col-like with a woody, phenolic nuance.
General Description
2-Methoxy-4-methylphenol is the major component of black-ripe table olive aroma. It is the major anti-inflammatory compound in bamboo vinegar. Kinetics of reaction of 2-methoxy-4-methylphenol with chlorine atoms was studied.
Biochem/physiol Actions
Odor at 1.0%
2-Methoxy-4-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1369 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
Related articles
- 2-Methoxy-4-methylphenol: Synthesis and Multifunctional Applications
- 2-Methoxy-4-methylphenol serves as biofuel/fragrance, and can be synthesized via non-noble metal catalysis or oxidized to vani....
- Oct 13，2025
View Lastest Price from 2-Methoxy-4-methylphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | 2-Methoxy-4-methylphenol
93-51-6
|
$3500.00-3900.00 | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
 |
2026-07-21 | Natural 4-Methyguaiacol
93-51-6
|
1kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-09 | 2-Methoxy-4-methylphenol
93-51-6
|
$1.20-31.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd |
-
- 2-Methoxy-4-methylphenol
93-51-6
- $3500.00-3900.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Natural 4-Methyguaiacol
93-51-6
- 99%
- Sinoway Industrial co., ltd.
-
- 2-Methoxy-4-methylphenol
93-51-6
- $1.20-31.00
- 99%
- Henan Fengda Chemical Co., Ltd
