3-Chloroaniline
- CAS No.
- 108-42-9
- Chemical Name:
- 3-Chloroaniline
- Synonyms
- M-CHLOROANILINE;3-CHLOROBENZENAMINE;3-Chloranilin;ORANGE GC BASE;3-Chloraniline;3-Cloroaniline;META-CHLOROANILINE;1,3-aminochlorobenzene;oroaniL;CI 37005
- CBNumber:
- CB9697982
- Molecular Formula:
- C6H6ClN
- Molecular Weight:
- 127.57
- MDL Number:
- MFCD00007765
- MOL File:
- 108-42-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Chloroaniline 99% | C22407 | 5g | $44.1 |
| 3-Chloroaniline 99% | C22407 | 100g | $60.4 |
| 3-Chloroaniline >99.0%(GC) | C0110 | 25mL | $18 |
| 3-Chloroaniline >99.0%(GC) | C0110 | 500mL | $93 |
| 3-Chloroaniline Asreported | 281661 | 500g | $460 |
| More product size | |||
| Melting point | −11-−9 °C(lit.) |
|---|---|
| Boiling point | 95-96 °C11 mm Hg(lit.) |
| Density | 1.206 g/mL at 25 °C(lit.) |
| vapor pressure | 1 mm Hg ( 63.5 °C) |
| refractive index |
n |
| Flash point | 255 °F |
| storage temp. | Store below +30°C. |
| solubility | 6.2g/l |
| form | Liquid |
| pka | 3.46(at 25℃) |
| color | Clear pale yellow to brown |
| PH | 7.3 (H2O)(saturated aqueous solution) |
| Odor | Characteristic odour |
| Water Solubility | 6.8 g/L (20 ºC) |
| Decomposition | 190°C |
| Merck | 14,2118 |
| BRN | 605969 |
| Henry's Law Constant | 4.7×100 mol/(m3Pa) at 25℃, Chao et al. (2017) |
| Dielectric constant | 13.4（19℃） |
| Stability | Material darkens in storage with no loss in purity, Material Darkens In Storage |
| InChI | 1S/C6H6ClN/c7-5-2-1-3-6(8)4-5/h1-4H,8H2 |
| InChIKey | PNPCRKVUWYDDST-UHFFFAOYSA-N |
| SMILES | Nc1cccc(Cl)c1 |
| LogP | 0.77-2.03 at 25-30℃ |
| CAS DataBase Reference | 108-42-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6GKR52SKIY |
| NIST Chemistry Reference | m-Chloroaniline(108-42-9) |
| EPA Substance Registry System | m-Chloroaniline (108-42-9) |
| UNSPSC Code | 12352116 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H316-H319-H370-H372-H373-H410 | |||||||||
| Precautionary statements | P501-P273-P270-P260-P271-P264-P280-P391-P337+P313-P305+P351+P338-P308+P311-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 | |||||||||
| target organs | Endocrine system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 23/24/25-33-50/53 | |||||||||
| Safety Statements | 28-36/37-45-60-61-28A | |||||||||
| RIDADR | UN 2019 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BX0350000 | |||||||||
| F | 8-10-23 | |||||||||
| Autoignition Temperature | 705 °C | |||||||||
| Hazard Note | Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29214210 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Sens. 1B STOT RE 2 Oral |
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| Hazardous Substances Data | 108-42-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 256 mg/kg LD50 dermal Rat 250 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
3-Chloroaniline price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C22407 | 3-Chloroaniline 99% | 108-42-9 | 5g | $44.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | C22407 | 3-Chloroaniline 99% | 108-42-9 | 100g | $60.4 | 2026-04-30 | Buy |
| TCI Chemical | C0110 | 3-Chloroaniline >99.0%(GC) | 108-42-9 | 25mL | $18 | 2026-04-30 | Buy |
| TCI Chemical | C0110 | 3-Chloroaniline >99.0%(GC) | 108-42-9 | 500mL | $93 | 2026-04-30 | Buy |
| Usbiological | 281661 | 3-Chloroaniline Asreported | 108-42-9 | 500g | $460 | 2026-06-03 | Buy |
3-Chloroaniline Chemical Properties,Uses,Production
Description
m-Chloroaniline is used as an intermediate for pesticides, pharmaceuticals, and dyes. It is produced by lowpressure hydrogenation of 3-chloronitrobenzene in the liquid phase with noble metal and/or noble metal sulfide catalysts. The addition of metal oxides to the reaction helps avoid dehalogenation. The yield is approximately 98 %.
Chemical Properties
3-Chloroaniline is a clear pale yellow to brown liquid, which becomes darker during storage, insoluble in water, but soluble in ethanol, ether and acid solution.
Application
3-Chloroaniline is the intermediate of the herbicide chloraniline, and the intermediate of the pharmaceutical diuretic antihypertensive drug hydrochlorothiazide, and can be used to produce azo dyes.
3-Chloroaniline was the only aniline compound to increase plasmaALT/GPT activity at 48 h. It is employed in the bioaugmentation of activated sludge.
Uses
3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito rs.
Preparation
3-Chloroaniline is obtained by reducing 3-Nitrochlorobenzene with iron powder in the presence of ferrous sulfate.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 7313, 1995 DOI: 10.1016/0040-4039(95)01474-V
General Description
Colorless to light amber liquid with a sweet odor.
Air & Water Reactions
Sensitive to prolonged exposure to air and light and tends to darken during storage. Insoluble in water.
Reactivity Profile
3-Chloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.
Fire Hazard
3-Chloroaniline is combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Poison by ingestion, skin contact, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYES.
3-Chloroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Yancheng Longshen Chemical Co.,Ltd. | +86-18352073383 +86-18352073383 | sales@longshenchem.com | China | 100 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
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View Lastest Price from 3-Chloroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 3-Chloroaniline
108-42-9
|
1KG | ≥99% | 30 Tons/Month | Yancheng Longshen Chemical Co.,Ltd. | ||
 |
2026-03-20 | 3-Chloroaniline
108-42-9
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2023-10-08 | 3-Chloroaniline
108-42-9
|
$30.00 | 1KG | 99% | 20T | Firsky International Trade (Wuhan) Co., Ltd |
-
- 3-Chloroaniline
108-42-9
- $0.00
- ≥99%
- Yancheng Longshen Chemical Co.,Ltd.
-
- 3-Chloroaniline
108-42-9
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Chloroaniline
108-42-9
- $30.00
- 99%
- Firsky International Trade (Wuhan) Co., Ltd
