4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 170911-92-9
- Chemical Name:
- 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE;Itraconazole Impurity 54;1-Boc-4-(4-aminophenyl)azine;4-(4-Boc-piperazin-1-yl)aniline;1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE;4-(4-Aminophenyl)piperazine, N1-BOC protected;4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine;4-(4-Aminophenyl)piperazine, N1-BOC protected 98%;t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate;4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB9726019
- Molecular Formula:
- C15H23N3O2
- Molecular Weight:
- 277.36
- MDL Number:
- MFCD04115065
- MOL File:
- 170911-92-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate | A3499 | 5G | $147 |
| tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate | A3499 | 25G | $443 |
| 1-Boc-4-(4-aminophenyl)piperazine | 408932 | 250mg | $319 |
| 1-Boc-4-(4-aminophenyl)piperazine | 408932 | 1g | $425 |
| 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Asreported | 261372 | 500mg | $333 |
| More product size | |||
| Boiling point | 441.1±40.0 °C(Predicted) |
|---|---|
| Density | 1.145±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 7.69±0.10(Predicted) |
| form | Solid |
| Appearance | Brown to reddish brown Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)13-6-4-12(16)5-7-13/h4-7H,8-11,16H2,1-3H3 |
| InChIKey | RXFHRKPNLPBDGE-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2921420090 | |||||||||
| NFPA 704 |
|
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A3499 | tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate | 170911-92-9 | 5G | $147 | 2026-04-30 | Buy |
| TCI Chemical | A3499 | tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate | 170911-92-9 | 25G | $443 | 2026-04-30 | Buy |
| Usbiological | 408932 | 1-Boc-4-(4-aminophenyl)piperazine | 170911-92-9 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 408932 | 1-Boc-4-(4-aminophenyl)piperazine | 170911-92-9 | 1g | $425 | 2026-06-03 | Buy |
| Usbiological | 261372 | 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Asreported | 170911-92-9 | 500mg | $333 | 2026-06-03 | Buy |
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Uses
1-Boc-4-(4-aminophenyl)piperazine is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff.
Application
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester can be used as a standard or reference for the qualitative and quantitative analysis of impurities in the synthesis of related drugs, ensuring drug purity and quality control. For example, it can be used to detect process impurities in drugs containing the 4-(4-aminophenyl)piperazine structure, and assist in the development of drug quality standards.
Synthesis
182618-86-6
170911-92-9
The general procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate from tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate was as follows: first, tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (8.2 g, 26.68 mmol) was dissolved in methanol (100 mL), followed by purging with nitrogen and depressurization. Next, 10% wet palladium carbon catalyst was added to the solution and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst, and the filtrate was subsequently concentrated under reduced pressure to afford tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97% yield) as a dark blue oily product, which was used directly in subsequent reactions without further purification. The molecular formula of the product was C15H23N3O2, and the mass spectrometry analysis showed that the m/z was 277.9 (M + H).
References
[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: EP1215208, 2002, A2. Location in patent: Example C(101)
[3] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 77
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 55
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Zhonghan Chemical Technology Co., LTD. | +undefined15066662237 | 3281004549@qq.com | China | 291 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
View Lastest Price from 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester
170911-92-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-13 | 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co | |
 |
2020-01-13 | 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester
170911-92-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
- $6.68
- 97%-99%
- Career Henan Chemical Co
-
- 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
- $6.68
- 97%-99%
- Career Henan Chemical Co
