NAPHTHOL AS-E PHOSPHATE
- CAS No.
- 18228-17-6
- Chemical Name:
- NAPHTHOL AS-E PHOSPHATE
- Synonyms
- kg-501;KG-501 (2-naphthol-AS-E-phosphate);N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide;NASEP;KD-501;KG-501, 10 mM in DMSO;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
- CBNumber:
- CB9737978
- Molecular Formula:
- C17H13ClNO5P
- Molecular Weight:
- 377.72
- MDL Number:
- MFCD00042718
- MOL File:
- 18228-17-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Naphthol AS-E phosphate for histology | 70485 | 250mg | $116 |
| Naphthol AS-E Phosphate ≥98% | 33602 | 5mg | $69 |
| Naphthol AS-E Phosphate ≥98% | 33602 | 10mg | $120 |
| Naphthol AS-E Phosphate ≥98% | 33602 | 25mg | $263 |
| Naphthol AS-E phosphate, 60% | EN69791 | 1000mg | $210 |
| More product size | |||
| Density | 1.567±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 1.04±0.30(Predicted) |
| color | White to light yellow |
| BRN | 6664478 |
| Major Application | histology |
| InChI | 1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23) |
| InChIKey | RQAQWBFHPMSXKR-UHFFFAOYSA-N |
| SMILES | OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3 |
| FDA UNII | H6R6B93QFC |
| UNSPSC Code | 12352204 |
| NACRES | NA.83 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| F | 8-10-21 |
| Storage Class | 11 - Combustible Solids |
NAPHTHOL AS-E PHOSPHATE price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 70485 | Naphthol AS-E phosphate for histology | 18228-17-6 | 250mg | $116 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 5mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 10mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 25mg | $263 | 2026-04-30 | Buy |
| Biosynth | EN69791 | Naphthol AS-E phosphate, 60% | 18228-17-6 | 1000mg | $210 | 2026-06-04 | Buy |
NAPHTHOL AS-E PHOSPHATE Chemical Properties,Uses,Production
Uses
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biological Activity
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.
in vitro
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.
in vivo
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.
target
| Target | Value | ||||
| CREB () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9949 | 58 |
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