3',5'-Difluoroacetophenone
- CAS No.
- 123577-99-1
- Chemical Name:
- 3',5'-Difluoroacetophenone
- Synonyms
- 1-(3,5-difluorophenyl)ethan-1-one;3,5-DIFLUOROACETOPHENONE;CAS:123577-99-1;3', 5' -difluorophenone;3',5'-Difluoroacetophenone;3',5'-Difluoroacetophenone>3',5'-Difluoroacetophenone98%;3′,5′-Difluoroacetophenone,97%;3',5'-Difluoroacetophenone 98%;1-(3,5-Difluorophenyl)ethanone
- CBNumber:
- CB9744132
- Molecular Formula:
- C8H6F2O
- Molecular Weight:
- 156.13
- MDL Number:
- MFCD00042489
- MOL File:
- 123577-99-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3′,5′-Difluoroacetophenone 97% | 541168 | 5g | $62.4 |
| 3',5'-Difluoroacetophenone >97.0%(GC) | D3425 | 5g | $24 |
| 3',5'-Difluoroacetophenone >97.0%(GC) | D3425 | 25g | $112 |
| 3',5'-Difluoroacetophenone | FD64524 | 25g | $150 |
| 3',5'-Difluoroacetophenone | FD64524 | 50g | $181 |
| More product size | |||
| Melting point | 34-38 °C(lit.) |
|---|---|
| Boiling point | 94 °C |
| Density | 1.206±0.06 g/cm3(Predicted) |
| refractive index | 1.4876 |
| Flash point | 180 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Low Melting Solid |
| color | White to slightly yellow |
| BRN | 6798740 |
| InChI | InChI=1S/C8H6F2O/c1-5(11)6-2-7(9)4-8(10)3-6/h2-4H,1H3 |
| InChIKey | OXJLDNSPGPBDCP-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(F)=CC(F)=C1)C |
| CAS DataBase Reference | 123577-99-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,5-Difluoroacetophenone(123577-99-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-R36/37/38-36-26 | |||||||||
| Safety Statements | 26-36-S36-S26-36/37/38 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3',5'-Difluoroacetophenone price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 541168 | 3′,5′-Difluoroacetophenone 97% | 123577-99-1 | 5g | $62.4 | 2026-04-30 | Buy |
| TCI Chemical | D3425 | 3',5'-Difluoroacetophenone >97.0%(GC) | 123577-99-1 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | D3425 | 3',5'-Difluoroacetophenone >97.0%(GC) | 123577-99-1 | 25g | $112 | 2026-04-30 | Buy |
| Biosynth | FD64524 | 3',5'-Difluoroacetophenone | 123577-99-1 | 25g | $150 | 2026-06-04 | Buy |
| Biosynth | FD64524 | 3',5'-Difluoroacetophenone | 123577-99-1 | 50g | $181 | 2026-06-04 | Buy |
3',5'-Difluoroacetophenone Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
3′,5′-Difluoroacetophenone (3,5-Difluoroacetophenone) may be used to synthesize:
- (E)-3-(4-(1,5,9-trithia-13-azacyclohexadecan-13-yl)-phenyl)-1-(3,5-difluorophenyl)prop-2-en-1-one
- 1,3,5-triarylpyrazoline fluorophores containing a 16-membered thiazacrown ligand
- (±)-fluorinated-1-(3-morpholin-4-yl-phenyl)ethylamine
- (E)-1-(3,5-difluorophenyl)-3-(2,4-dimethoxyphenyl) prop-2-en-1-one
- 1-(3,5-difluorophenyl)-4,4,4-trifluorobutane-1,3-dione
General Description
3′,5′-Difluoroacetophenone, also known as 1-(3,5-difluorophenyl)ethanone, is a fluorinated acetophenone.
Synthesis
872181-59-4
123577-99-1
The general procedure for the synthesis of 3,5-difluoroacetophenone from 1-(3,5-difluorophenyl)ethanol was carried out as follows: a solution of Dess-Martin periodontane (9.66 g, 22.8 mmol) was added batchwise to a solution of 1-(3,5-difluorophenyl)ethanol (3.00 g, 19.0 mmol) in dichloromethane (40 mL) under ice-bath cooling conditions. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the solvent was removed by concentration under reduced pressure. The residue was purified by silica gel column chromatography using a CombiFlash device eluting with a gradient of ethyl acetate/hexane (0-40%). Purification afforded 3,5-difluoroacetophenone (2.06 g, 69.6% yield) as a colorless oil. Its 1H NMR (300 MHz, CDCl3) data were as follows: δ 7.45 (m, 2H), 7.01 (m, 1H), 2.59 (s, 3H) ppm.
References
[1] Patent: US2014/200227, 2014, A1. Location in patent: Paragraph 1098; 1099
3',5'-Difluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from 3',5'-Difluoroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 3',5'-Difluoroacetophenone
123577-99-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-12-23 | 3',5'-Difluoroacetophenone
123577-99-1
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3',5'-Difluoroacetophenone
123577-99-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3',5'-Difluoroacetophenone
123577-99-1
- $9.80
- ≥99%
- Career Henan Chemical Co
123577-99-1(3',5'-Difluoroacetophenone)Related Search:
1of4
