8-MERCAPTOADENOSINE
- CAS No.
- 3001-45-4
- Chemical Name:
- 8-MERCAPTOADENOSINE
- Synonyms
- 8-Thioadenosine;8-MERCAPTOADENOSINE;Adenosine,7,8-dihydro-8-thioxo-;7,8-Dihydro-8- thioxo- adenosine;6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8,9-dihydro-7H-purine-8-thione;6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione
- CBNumber:
- CB9824069
- Molecular Formula:
- C10H13N5O4S
- Molecular Weight:
- 299.31
- MDL Number:
- MFCD01318026
- MOL File:
- 3001-45-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 7,8-Dihydro-8-thioxo-adenosine | ND76854 | 1g | $524.72 |
| 7,8-Dihydro-8-thioxo-adenosine | ND76854 | 2g | $974.5 |
| 7,8-Dihydro-8-thioxo-adenosine | ND76854 | 5g | $2173.85 |
| 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione | 307598 | 250.00mg | $32 |
| 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione | 307598 | 1.00g | $74 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P280 |
8-MERCAPTOADENOSINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ND76854 | 7,8-Dihydro-8-thioxo-adenosine | 3001-45-4 | 1g | $524.72 | 2026-06-04 | Buy |
| Biosynth | ND76854 | 7,8-Dihydro-8-thioxo-adenosine | 3001-45-4 | 2g | $974.5 | 2026-06-04 | Buy |
| Biosynth | ND76854 | 7,8-Dihydro-8-thioxo-adenosine | 3001-45-4 | 5g | $2173.85 | 2026-06-04 | Buy |
| Matrix Scientific | 307598 | 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione | 3001-45-4 | 250.00mg | $32 | 2026-05-19 | Buy |
| Matrix Scientific | 307598 | 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione | 3001-45-4 | 1.00g | $74 | 2026-05-19 | Buy |
8-MERCAPTOADENOSINE Chemical Properties,Uses,Production
Uses
8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase[1].
Synthesis
2946-39-6
3001-45-4
The general procedure for the synthesis of 6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-3,4-diol of 6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione from (2R,3R,4S,5R)-2-(6-amino-8-bromo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl) was as follows : 1. NaSH (0.8 g, 10 equiv) was added to a solution of 8-bromoadenine (0.5 g, 1.44 mmol) in DMF (7 mL). 2. heat the mixture to 100 °C and add a small amount of water to increase solubility. 3. Stir the reaction mixture at 100°C overnight. 4. the solvent is evaporated under high vacuum and the residue is co-evaporated with methanol several times until a solid is formed. 5. the residue is dissolved in water and neutralized with NaOH solution. 6. After freeze-drying, the product was purified by silica gel column chromatography (eluent: CHCl3:MeOH = 10:1). 7. The target compound was obtained as a light yellow powder (100% yield, melting point 169-170°C). Product characterization data: 1H-NMR (CD3OD, 200 MHz): δ 8.09 (s, 1H, H-2), 6.65 (d, J = 7 Hz, 1H, H-1'), 5.01 (dd, J = 7, 5.5 Hz, 1H, H-2'), 4.39 (dd, J = 5.5, 2.5 Hz, 1H, H-3'), 4.13 (q, J = 2.5 Hz. 1H, H-4'), 3.87 (dd, J = 12.5, 2.5 Hz, 1H, H-5'), 3.71 (dd, J = 1.25, 3 Hz, 1H, H-5''). 13C-NMR (CD3OD, 300 MHz): δ 167.88 (C-6), 151.92 (C-2), 148.12 (C-4), 147.88 (C-8), 107.00 (C-5), 88.62 (C-1'), 85.59 (C-4'), 70.70 (C-2'), 70.62 (C-3') , 62.13 (C-5'). MS (CI/NH3): m/z 317 [M + NH4]+.
References
[1] M Ikehara, et al. Studies of nucleosides and nucleotides. LVI. A versatile method for the systhesis of 8-mercaptoadenosine nucleotides. Chem Pharm Bull (Tokyo). 1973 Feb;21(2):444-5. DOI:10.1248/cpb.21.444
8-MERCAPTOADENOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-MERCAPTOADENOSINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9985 | 58 |
| Shenzhen Nexcon Pharmatechs Ltd. | +86-0755-89396905 +86-18025329037 | admin@nexconn.com | China | 5281 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232 | 1282296214@qq.com | China | 497 | 55 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Wellman Pharmaceutical Group Limited | 15807197853 18971451745 | 15807197853@163.com | China | 3626 | 58 |
| Rhawn Reagent | 400-400-1332688 18019345275 | huyue@rhawn.cn | China | 14948 | 58 |
| Fuyang Ziyi Biological Pharmaceutical Co., Ltd. | 19308655899; 19308655899 | 2677609105@qq.com | China | 500 | 58 |
View Lastest Price from 8-MERCAPTOADENOSINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-30 | 8-MERCAPTOADENOSINE
3001-45-4
|
1G | 97% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. |
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- 8-MERCAPTOADENOSINE
3001-45-4
- 97%
- Shenzhen Nexcon Pharmatechs Ltd.
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