5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
![5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE Structure](CAS/GIF/40707-01-5.gif)
- CAS No.
- 40707-01-5
- Chemical Name:
- 5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
- Synonyms
- LAQU-006;5-chloro-1-methyl-3,1-benzoxazine-2,4-dione;5-Chloro-1-methylbenzo[d][1,3]oxazine-2,4-dione;5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;2H-3,1-Benzoxazine-2,4(1H)-dione, 5-chloro-1-Methyl-;5-chloro-1-Methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
- CBNumber:
- CB9839779
- Molecular Formula:
- C9H6ClNO3
- Molecular Weight:
- 211.6
- MDL Number:
- MFCD00047630
- MOL File:
- 40707-01-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | C50899 | 250mg | $18 |
| 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | C50899 | 1g | $30 |
| 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | C50899 | 5g | $130 |
| 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | AA00C6A8 | 250mg | $7 |
| 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | AA00C6A8 | 1g | $17 |
| More product size | |||
| Melting point | 217.9-218.2 °C |
|---|---|
| Boiling point | 344.8±44.0 °C(Predicted) |
| Density | 1.476±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -3.48±0.20(Predicted) |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C9H6ClNO3/c1-11-6-4-2-3-5(10)7(6)8(12)14-9(11)13/h2-4H,1H3 |
| InChIKey | BTNWNXWHFWYONH-UHFFFAOYSA-N |
| SMILES | N1(C)C2=CC=CC(Cl)=C2C(=O)OC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | C50899 | 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | 40707-01-5 | 250mg | $18 | 2026-05-06 | Buy |
| Synthonix | C50899 | 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | 40707-01-5 | 1g | $30 | 2026-05-06 | Buy |
| Synthonix | C50899 | 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | 40707-01-5 | 5g | $130 | 2026-05-06 | Buy |
| aablocks | AA00C6A8 | 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | 40707-01-5 | 250mg | $7 | 2026-05-28 | Buy |
| aablocks | AA00C6A8 | 5-Chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 97% | 40707-01-5 | 1g | $17 | 2026-05-28 | Buy |
5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE Chemical Properties,Uses,Production
Synthesis
20829-96-3
74-88-4
![5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE](/CAS/GIF/40707-01-5.gif)
40707-01-5
General procedure for the synthesis of 5-chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-diones from 5-chloro-1H-benzo[d][1,3]oxazine-2,4-diones and iodomethane: Iodomethane (2 mL, 4.6 mmol, 4 equiv) and N,N-diisopropylethylamine (DIPEA, 1 mL, 0.74 mol) were suspended at room temperature in N,N-dimethylacetamide (DMA, 10 mL) and stirred for 10 min. Subsequently, 5-chloroisatoic anhydride (200 mg, 1.01 mmol, 1 eq.) was added and the reaction mixture was stirred at 40 °C for 5 hours. Upon completion of the reaction, the resulting product 5-chloro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione was collected by filtration and washed with distilled water to give the pure product (150 mg, 70% yield). The melting point of the product was 224 °C. Infrared spectra (KBr) showed characteristic absorption peaks υ1774, 1716, 1593 cm^-1. 1H NMR (DMSO-d6, 300 MHz) δ 7.78 (t, J = 8.1 Hz, 1H), 7.42 (m, 2H), 3.45 (s, 3H). Elemental analysis results: calculated values for C9H6ClNO3: C, 51.08; H, 2.86; Cl, 16.75; N, 6.62; O, 22.68. measured values: C, 51.12; H, 2.36; Cl, 16.71; N, 6.58.
References
[1] Organic Process Research and Development, 2007, vol. 11, # 4, p. 674 - 680
[2] Journal of Heterocyclic Chemistry, 2016, vol. 53, # 2, p. 437 - 440
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 1 - 10
[4] Monatshefte fur Chemie, 2016, vol. 147, # 6, p. 1069 - 1079
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 8, p. 2075 - 2088
5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3709 | 55 |
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 961 | 65 |
| Nanjing Norris-Pharm Technology Co., Ltd | 18652989687 | sales@norris-pharm.com | China | 8878 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| ShangHai D&B Biological Science and Technology Co.Ltd | 400-008-9730,021-54359730 400-008-9730 | info@chemxyz.com | China | 3645 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1958 | 62 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6939 | 55 |
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