Scopine-2,2-dithienyl glycolate
- CAS No.
- 136310-64-0
- Chemical Name:
- Scopine-2,2-dithienyl glycolate
- Synonyms
- N-DeMethyl TiotropiuM;N-Desmethyl Tiotropium;Tiotropium EP Impurity B;SCOPINE-2,2-DITHIENYL GLYCOLATE;Tiotropium Bromide EP Impurity B;Scopolamine 2-(2-thienyl)glycolate;CO base bis (2-thiophenyl) glycolate;Scopolamine 2- (2-thiophenyl) glycolate;Scopine-2,2-dithienyl glycolate USP/EP/BP;Tiotropium Bromide Monohydrate Impurity B
- CBNumber:
- CB9843604
- Molecular Formula:
- C18H19NO4S2
- Molecular Weight:
- 377.48
- MDL Number:
- MFCD09038796
- MOL File:
- 136310-64-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Scopine-2,2-dithienyl glycolate Asreported | 289046 | 1g | $991 |
| Scopine-2,2-dithienyl glycolate Asreported | 289046 | 2g | $1210 |
| Scopine-2,2-dithienyl glycolate Asreported | 289046 | 5g | $2478 |
| Scopine-2,2-dithienyl glycolate Asreported | 289046 | 10g | $4000 |
| Scopine-2,2-dithienyl glycolate Asreported | 289046 | 25g | $6105 |
| More product size | |||
| Melting point | 138-140°C |
|---|---|
| Boiling point | 542.3±50.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 10.32±0.29(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Scopine-2,2-dithienyl glycolate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 289046 | Scopine-2,2-dithienyl glycolate Asreported | 136310-64-0 | 1g | $991 | 2026-06-03 | Buy |
| Usbiological | 289046 | Scopine-2,2-dithienyl glycolate Asreported | 136310-64-0 | 2g | $1210 | 2026-06-03 | Buy |
| Usbiological | 289046 | Scopine-2,2-dithienyl glycolate Asreported | 136310-64-0 | 5g | $2478 | 2026-06-03 | Buy |
| Usbiological | 289046 | Scopine-2,2-dithienyl glycolate Asreported | 136310-64-0 | 10g | $4000 | 2026-06-03 | Buy |
| Usbiological | 289046 | Scopine-2,2-dithienyl glycolate Asreported | 136310-64-0 | 25g | $6105 | 2026-06-03 | Buy |
Scopine-2,2-dithienyl glycolate Chemical Properties,Uses,Production
Description
Scopine-2,2-dithienyl glycolate is an organic compound. It is off-white solid. The melting point is 138-140°C. The storage temperature is -20°C. Scopine-2,2-dithienyl glycolate is one of the reaction intermediates in the preparation of tiotropium bromide, which is a highly effective anticholinergic agent and widely used for treatment of asthma and/or chronic obstructive pulmonary disease (COPD) (chronic obstructive pulmonary disease).
Chemical Properties
Off-White Solid
Uses
Scopine Di(2-thienylglycolate) (Tiotropium EP Impurity B) is a precursor to Tiotropium Bromide.
Synthesis
26447-85-8
498-45-3
136310-64-0
Example 1: 7 mol% NHC (relative to compound (1)) in THF at room temperature. In an anhydrous flask containing about 7.85 g of activated 4A molecular sieves, methyl 2,2-dithienylglycolate (2) (R = Me, 3.97 g, 15.6 mmol) and rel-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (1) (2.61 g. 16.8 mmol) was dissolved in THF (14 mL). Another flask was taken and 1-butyl-3-methylimidazolium tetrafluoroborate (210 μL, 1.12 mmol), KOtBu/THF solution (960 μL, 0.96 mmol), and THF (1.0 mL) were added, and stirred for 15 min at room temperature. Subsequently, this mixture was transferred to a flask containing rel-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol solution using a syringe. The syringe and flask were washed with THF (2 x 0.5 mL) and the reaction mixture was stirred at room temperature for 18 h. HPLC analysis showed 86% yield of the expected product.After 18 h, the mixture was filtered and the molecular sieves were washed with THF (2 x 20 mL). The filtrate was concentrated to dryness and the residue was dissolved in toluene (30 mL) and 1M HCl (30 mL). Solid precipitation was observed during phase separation; the suspension was filtered and the solids were washed with toluene (30 mL) and redissolved in the separated aqueous phase. The aqueous phase suspension was cooled to 0 °C and alkalized to the proper pH by adding solid K2CO3. The mixture was stirred at 0 °C for about 30 min, and the resulting solid was filtered, washed with cold water, and dried first on a filter, followed by vacuum drying at 45 °C for 18 h to give the white solid product (3) (4.30 g, 73%, HPLC purity = 99.89%).
References
[1] Patent: WO2013/46138, 2013, A1. Location in patent: Page/Page column 9; 10
[2] Patent: US2004/242622, 2004, A1. Location in patent: Page 29
[3] ChemMedChem, 2017, vol. 12, # 15, p. 1173 - 1182
[4] Patent: US2014/303373, 2014, A1. Location in patent: Paragraph 0034; 0035; 0036; 0037
Scopine-2,2-dithienyl glycolate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 296 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
View Lastest Price from Scopine-2,2-dithienyl glycolate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-05 | Scopine-2,2-dithienyl glycolate
136310-64-0
|
$85.00-850.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-03-20 | Scopine-2,2-dithienyl glycolate
136310-64-0
|
$25.00 | 100g | 99.5% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | Scopine-2,2-dithienyl glycolate
136310-64-0
|
1kg | 0.99 | 100tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Scopine-2,2-dithienyl glycolate
136310-64-0
- $85.00-850.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Scopine-2,2-dithienyl glycolate
136310-64-0
- $25.00
- 99.5%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Scopine-2,2-dithienyl glycolate
136310-64-0
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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