5-CYANO-2-THIOPHENE CARBALDEHYDE
- CAS No.
- 21512-16-3
- Chemical Name:
- 5-CYANO-2-THIOPHENE CARBALDEHYDE
- Synonyms
- 5-Cyanothiophene-2-carbaldehyde;5-Formyl-2-thiophenecarbonitrile;5-CYANO-2-THIOPHENE CARBALDEHYDE;5-Formyl-thiophene-2-carbonitrile;5-Cyanothiophene-2-carboxaldehyde;5-Cyanothiophene-2-carboxyaldehyde;2-Thiophenecarbonitrile, 5-formyl-;5-aldehyde-2-thiophenecarbonitrile;5-Cyanothiophene-2-carboxaldehyde 97%;5-Cyano-2-thiophene carbaldehyde, 95+%
- CBNumber:
- CB9845653
- Molecular Formula:
- C6H3NOS
- Molecular Weight:
- 137.16
- MDL Number:
- MFCD09037804
- MOL File:
- 21512-16-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-cyano-2-thiophene carbaldehyde AldrichCPR | CDS012107 | 100 mg | $191 |
| 5-Cyanothiophene-2-carboxaldehyde 97% | 738263 | 1g | $82.8 |
| 5-Formylthiophene-2-carbonitrile >98.0%(GC) | F1133 | 1g | $76 |
| 5-Formylthiophene-2-carbonitrile >98.0%(GC) | F1133 | 5g | $297 |
| 5-Cyanothiophene-2-carboxaldehyde | TRC-C982260-500MG | 500mg | $129 |
| More product size | |||
| Melting point | 90-95℃ |
|---|---|
| Boiling point | 130-135 °C(Press: 1.2 Torr) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White |
| Water Solubility | Slightly soluble in water. |
| InChI | 1S/C6H3NOS/c7-3-5-1-2-6(4-8)9-5/h1-2,4H |
| InChIKey | PZIFYWVUYHMYOA-UHFFFAOYSA-N |
| SMILES | O=Cc1ccc(s1)C#N |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 3439 6.1/PG III | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
5-CYANO-2-THIOPHENE CARBALDEHYDE price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS012107 | 5-cyano-2-thiophene carbaldehyde AldrichCPR | 100 mg | $191 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 738263 | 5-Cyanothiophene-2-carboxaldehyde 97% | 21512-16-3 | 1g | $82.8 | 2023-06-20 | Buy |
| TCI Chemical | F1133 | 5-Formylthiophene-2-carbonitrile >98.0%(GC) | 21512-16-3 | 1g | $76 | 2026-04-30 | Buy |
| TCI Chemical | F1133 | 5-Formylthiophene-2-carbonitrile >98.0%(GC) | 21512-16-3 | 5g | $297 | 2026-04-30 | Buy |
| TRC | TRC-C982260-500MG | 5-Cyanothiophene-2-carboxaldehyde | 21512-16-3 | 500mg | $129 | 2026-06-03 | Buy |
5-CYANO-2-THIOPHENE CARBALDEHYDE Chemical Properties,Uses,Production
Uses
5-Cyanothiophene-2-carboxaldehyde is found in caper and may have pest control activity against meloidogyne incognita.
Synthesis
1003-31-2
68-12-2
21512-16-3
Under the protection of inert atmosphere, n-butyllithium (BuLi, 11.7 mL, 29.3 mmol, 2.5 M solution) was slowly added to a mixture containing diisopropylamine (4.1 mL, 29.3 mmol) and tetrahydrofuran (THF, 150 mL), keeping the temperature lower than -70°C. After addition, the reaction mixture was allowed to gradually warm up to room temperature. Subsequently, the mixture was cooled again to -70°C and a THF solution (15 mL) containing 2-cyanothiophene (3.0 g, 26.7 mmol) was slowly added dropwise at this temperature, and stirring was continued at -78°C for 1 hr after completion of the dropwise addition. Maintaining the reaction temperature below -70°C, N,N-dimethylformamide (DMF, 8.2 mL, 106.6 mmol) was added, followed by continued stirring at -78°C for 1.5 hours. Upon completion of the reaction, citric acid (10 g) was added to the mixture and the entire reaction mixture was poured into water. Diethyl ether extraction was carried out with the water phase and the organic phases were combined, dried and concentrated. The crude product was purified by silica gel column chromatography with an eluent gradient of 10-50% heptane/ethyl acetate (EtOAc). The final product was obtained as 5-formyl-2-thiophenecarbonitrile as a solid with a yield of 2.8 g in 76% yield.
References
[1] Patent: WO2011/73298, 2011, A1. Location in patent: Page/Page column 18
[2] Patent: US2008/200535, 2008, A1. Location in patent: Page/Page column 169
5-CYANO-2-THIOPHENE CARBALDEHYDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9067 | 58 |
| Nanjing Yushan Wanfang Biotechnology Co., Ltd. | +86-025-84918180 +86-18014482516 | 3552541679@qq.com | China | 997 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9981 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from 5-CYANO-2-THIOPHENE CARBALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-05 | 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
|
$9.80 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-CYANO-2-THIOPHENE CARBALDEHYDE
21512-16-3
- $9.80
- 97%-99%
- Career Henan Chemical Co
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