4-Chlorotoluene
- CAS No.
- 106-43-4
- Chemical Name:
- 4-Chlorotoluene
- Synonyms
- 1-CHLORO-4-METHYLBENZENE;P-CHLOROTOLUENE;chlorotoluenes;UPD;p-chloro-toluen;1-chloro-4-methyl-benzen;4-CHLORO-1-METHYLBENZENE;4-Chlorotoluene p-Chlorotoluene;p-ChL;p-Chlortoluol
- CBNumber:
- CB9852675
- Molecular Formula:
- C7H7Cl
- Molecular Weight:
- 126.58
- MDL Number:
- MFCD00000631
- MOL File:
- 106-43-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Chlorotoluene 98% | 111929 | 100g | $118 |
| 4-Chlorotoluene 98% | 111929 | 500g | $260 |
| Anti-UROD antibody produced in goat affinity isolated antibody, buffered aqueous solution | SAB2502168 | 100μG | $545 |
| 4-Chlorotoluene | C0297 | 25G | $28 |
| 4-Chlorotoluene | C0297 | 500G | $72 |
| More product size | |||
| Melting point | 6-8 °C(lit.) |
|---|---|
| Boiling point | 162 °C(lit.) |
| Density | 1.07 g/mL at 25 °C(lit.) |
| vapor density | 4.38 (vs air) |
| vapor pressure | 10 mm Hg ( 45 °C) |
| refractive index |
n |
| Flash point | 121 °F |
| storage temp. | 2-8°C |
| solubility | 0.040g/l |
| form | Liquid |
| color | Clear |
| PH | 7.4 (H2O)(saturated aqueous solution) |
| explosive limit | 0.7-12.2%(V) |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Merck | 14,2171 |
| BRN | 1903635 |
| Henry's Law Constant | 2.7×10-3 mol/(m3Pa) at 25℃, Brockbank (2013) |
| Dielectric constant | 6.0800000000000001 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3 |
| InChIKey | NPDACUSDTOMAMK-UHFFFAOYSA-N |
| SMILES | Cc1ccc(Cl)cc1 |
| LogP | 3.33 at 20℃ |
| CAS DataBase Reference | 106-43-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | PCT |
| FDA UNII | Q8R236H42N |
| NIST Chemistry Reference | Benzene, 1-chloro-4-methyl-(106-43-4) |
| EPA Substance Registry System | p-Chlorotoluene (106-43-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS07,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H303-H361-H317-H305-H411-H226 | |||||||||
| Precautionary statements | P501-P273-P272-P202-P240-P261-P210-P233-P201-P243-P241-P242-P271-P280-P370+P378-P312-P391-P331-P362+P364-P303+P361+P353-P333+P313-P301+P310-P304+P340+P312-P403+P235-P405 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,N,T,F | |||||||||
| Risk Statements | 20-51/53-39/23/24/25-23/24/25-11-10-43 | |||||||||
| Safety Statements | 24/25-61-45-36/37-16-7 | |||||||||
| RIDADR | UN 2238 3/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XS9010000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29036990 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Inhalation Aquatic Chronic 2 Flam. Liq. 3 Skin Sens. 1 |
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| Hazardous Substances Data | 106-43-4(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Chlorotoluene price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 111929 | 4-Chlorotoluene 98% | 106-43-4 | 100g | $118 | 2026-04-30 | Buy |
| Sigma-Aldrich | 111929 | 4-Chlorotoluene 98% | 106-43-4 | 500g | $260 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB2502168 | Anti-UROD antibody produced in goat affinity isolated antibody, buffered aqueous solution | 106-43-4 | 100μG | $545 | 2023-01-07 | Buy |
| TCI Chemical | C0297 | 4-Chlorotoluene | 106-43-4 | 25G | $28 | 2026-04-30 | Buy |
| TCI Chemical | C0297 | 4-Chlorotoluene | 106-43-4 | 500G | $72 | 2026-04-30 | Buy |
4-Chlorotoluene Chemical Properties,Uses,Production
Chemical Properties
Colorless oily liquid. Slightly soluble in water. Soluble in ethanol, ether, acetone, benzene and chloroform.
Uses
4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. It is also used for the preparation model gas of 4-chlorotoulene by passing synthesized air into liquid 4-chlorotoulene.
Application
4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook]
Definition
ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. It is an intermediate for the manufacture of Fenvalerate, Paclobutrazol, Uniconazole, Trifluralin,Thiobencarb, Daimuron and other pesticides.
Preparation
4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene.
General Description
The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors.
Hazard
Avoid inhalation; strong irritant.
Flammability and Explosibility
Flammable
Safety Profile
Moderately toxic by ingestion. Mdly toxic by inhalation. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLYL CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.
Purification Methods
Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.]
4-Chlorotoluene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xin Cheng Yue Chemical Co.,Ltd | +86-021-57806787 +86-17701820076 | wuziwei@xinyuefirm.com | China | 31 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
View Lastest Price from 4-Chlorotoluene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-23 | 4-Chlorotoluene
106-43-4
|
$1.00 | 1KG | 99.5% | 1000mt/year | Jinan Finer Chemical Co., Ltd | |
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2026-07-20 | 4-Chlorotoluene
106-43-4
|
1000kg | 99.8% | 100000ton | Shanghai Xin Cheng Yue Chemical Co.,Ltd | ||
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2026-07-09 | 4-Chlorotoluene
106-43-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 4-Chlorotoluene
106-43-4
- $1.00
- 99.5%
- Jinan Finer Chemical Co., Ltd
-
- 4-Chlorotoluene
106-43-4
- 99.8%
- Shanghai Xin Cheng Yue Chemical Co.,Ltd
-
- 4-Chlorotoluene
106-43-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
