3-azaspiro[5.5]undecane hydrochloride
![3-azaspiro[5.5]undecane hydrochloride Structure](CAS/GIF/1125-01-5.gif)
- CAS No.
- 1125-01-5
- Chemical Name:
- 3-azaspiro[5.5]undecane hydrochloride
- Synonyms
- hydrochloride - [A81406];3-Azaspiro[5.5]undecane HCl;4,4-Pentamethylenepiperidine;4,4-Pentamethylenepiperidine HCl;9-azaspiro[5.5]undecane chloride;3-azaspiro[5.5]undecane hydrochloride
- CBNumber:
- CB9923980
- Molecular Formula:
- C10H20ClN
- Molecular Weight:
- 189.7255
- MDL Number:
- MFCD02093801
- MOL File:
- 1125-01-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,4-Pentamethylenepiperidine hydrochloride Asreported | 254415 | 50mg | $366 |
| 4,4-Pentamethylenepiperidine | 019241 | 100mg | $403 |
| 3-Azaspiro[5.5]undecane hydrochloride ≥97% | CS-0029483 | 1g | $80 |
| 3-Azaspiro[5.5]undecane hydrochloride ≥97% | CS-0029483 | 5g | $296 |
| 3-Azaspiro[5.5]undecane hydrochloride ≥97% | CS-0029483 | 10g | $591 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H315-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
3-azaspiro[5.5]undecane hydrochloride price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 254415 | 4,4-Pentamethylenepiperidine hydrochloride Asreported | 1125-01-5 | 50mg | $366 | 2026-06-03 | Buy |
| Usbiological | 019241 | 4,4-Pentamethylenepiperidine | 1125-01-5 | 100mg | $403 | 2026-06-03 | Buy |
| ChemScene | CS-0029483 | 3-Azaspiro[5.5]undecane hydrochloride ≥97% | 1125-01-5 | 1g | $80 | 2026-06-04 | Buy |
| ChemScene | CS-0029483 | 3-Azaspiro[5.5]undecane hydrochloride ≥97% | 1125-01-5 | 5g | $296 | 2026-06-04 | Buy |
| ChemScene | CS-0029483 | 3-Azaspiro[5.5]undecane hydrochloride ≥97% | 1125-01-5 | 10g | $591 | 2026-06-04 | Buy |
3-azaspiro[5.5]undecane hydrochloride Chemical Properties,Uses,Production
Uses
4,4-Pentamethylenepiperidine Hydrochloride is a M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2).
Uses
A M2 proton channel blocker. Inhibits influenza virus M2 protein (AM2).
Synthesis
1130-32-1
![3-azaspiro[5.5]undecane hydrochloride](/CAS/GIF/1125-01-5.gif)
1125-01-5
The synthesis of BL-1743 started with 3,3-cyclopentane glutarimide, which was first subjected to a reductive reaction with lithium aluminum hydride (LiAlH4) in tetrahydrofuran (THF) under refluxing conditions to afford 3-azaspiro[5,5]undecane hydrochloride (9), which was followed by treatment with HCl/ethyl ether to obtain the target product in 75% yield (see Scheme 1). Next, model compound BL-1743 was prepared by nucleophilic substitution of compound 9 by 2-methylthio-2-imidazoline.In addition, compound 9 was subjected to reductive amination with different aldehydes in dichloroethane using sodium triacetoxyborohydride (NaBH(OAc)3) and formic acid (HCO2H) as reducing agents to afford derivatives 1-8 in yields ranging from 65% to 95%. The results of activity tests showed that the inhibitory activity of BL-1743 was completely lost at 100 μM concentration after the imidazoline ring was replaced by a hydrophobic substituent or a heterocyclic ring that lacked a hydrogen bond donor (HBD), and the AM2 activity remained >90%. In contrast, inhibitors 7 and 8 containing an imidazole head group showed moderate inhibitory activity, suggesting that the presence of a hydrogen bond donor may be a structural feature necessary for inhibitory activity.
References
[1] Patent: US2010/69420, 2010, A1. Location in patent: Page/Page column 7
3-azaspiro[5.5]undecane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| Supplier | Advantage |
|---|---|
| Capot Chemical Co.,Ltd. | 60 |
| Alchem Pharmtech,Inc. | 58 |
| Career Henan Chemica Co | 58 |
| Win-Win chemical CO., Limited | 58 |
| BOC Sciences | 58 |
| Nextpeptide Inc | 58 |
| Labnetwork lnc. | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | 58 |
| Aladdin Scientific | 58 |
| Suzhou ARTK Medchem Co., Ltd. | 58 |
