2-Amino-5-Methyl-Benzonitrile
- CAS No.
- 5925-93-9
- Chemical Name:
- 2-Amino-5-Methyl-Benzonitrile
- Synonyms
- 2-Amino-5-methylbenzonitrile;6-Amino-m-tolunitrile;4-Amino-3-cyanotoluene;2-Cyano-4-methylaniline;2-amino-5-methylbenzenitrile;Benzonitrile, 2-amino-5-methyl-;2-Amino-5-methylbenzonitrile 97%;2-azanyl-5-methyl-benzenecarbonitrile;(5Z)-5-[(4-methoxyphenyl)methylidene]-2-phenyl-6-thiazolo[3,2-b][1,2,4]triazolone
- CBNumber:
- CB9949812
- Molecular Formula:
- C8H8N2
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD00267506
- MOL File:
- 5925-93-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-5-methylbenzonitrile 97% | 696331 | 1g | $45.6 |
| 2-Amino-5-methylbenzonitrile >97.0%(GC) | A2843 | 1g | $89 |
| 2-Amino-5-methylbenzonitrile Asreported | 260038 | 500mg | $326 |
| 2-Amino-5-methylbenzonitrile Asreported | 260038 | 1g | $445 |
| 2-Amino-5-methylbenzonitrile Asreported | 260038 | 2g | $582 |
| More product size | |||
| Melting point | 59-63 °C |
|---|---|
| Boiling point | 152°C/15mmHg(lit.) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| pka | 2.25±0.10(Predicted) |
| form | Solid |
| color | White to Brown |
| InChI | 1S/C8H8N2/c1-6-2-3-8(10)7(4-6)5-9/h2-4H,10H2,1H3 |
| InChIKey | OZLMBXPYRDASTP-UHFFFAOYSA-N |
| SMILES | Cc1ccc(N)c(c1)C#N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Amino-5-Methyl-Benzonitrile price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 696331 | 2-Amino-5-methylbenzonitrile 97% | 5925-93-9 | 1g | $45.6 | 2023-01-07 | Buy |
| TCI Chemical | A2843 | 2-Amino-5-methylbenzonitrile >97.0%(GC) | 5925-93-9 | 1g | $89 | 2026-04-30 | Buy |
| Usbiological | 260038 | 2-Amino-5-methylbenzonitrile Asreported | 5925-93-9 | 500mg | $326 | 2026-06-03 | Buy |
| Usbiological | 260038 | 2-Amino-5-methylbenzonitrile Asreported | 5925-93-9 | 1g | $445 | 2026-06-03 | Buy |
| Usbiological | 260038 | 2-Amino-5-methylbenzonitrile Asreported | 5925-93-9 | 2g | $582 | 2026-06-03 | Buy |
2-Amino-5-Methyl-Benzonitrile Chemical Properties,Uses,Production
Uses
2-Amino-5-methylbenzonitrile can be used in combination therapy to treat Mucopolysaccharidosis I.
Synthesis
64113-86-6
5925-93-9
5-Methyl-2-nitrobenzonitrile (1.92 g, 11.84 mmol) was added in batches to a mixed solution of concentrated hydrochloric acid (12 mL) and ethanol (EtOH, 12 mL) with SnCl2 (11.22 g, 59.2 mmol) in stirring. The temperature was controlled at 20-30 °C using an ice bath during the reaction. The reaction mixture was continued to be stirred at room temperature for 1 h. The reaction mixture was then poured into pre-cooled aqueous 6N NaOH solution (ca. 30 mL) and neutralized to pH 7. The product was extracted with ethyl acetate (EtOAc), followed by washing of the organic layer with brine, drying with anhydrous magnesium sulfate (MgSO4), and concentration to give the target product, 2-amino-5-methylbenzonitrile (1.56 g, 99% yield) as a yellowish brown solid. The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6) δ 2.21 (s, 3H), 5.79 (bs, 2H), 6.68-6.71 (d, 1H), 7.10-7.13 (dd, 1H), 7.15 (s, 1H); 13C NMR (DMSO-d6) δ 20.13,93.99,116.12, 118.94,125.38,132.32,135.76,150.21; mass spectrum (MS) m/z 133 (MH+) confirmed.
References
[1] Patent: US2008/306053, 2008, A1. Location in patent: Page/Page column 60
[2] Tetrahedron, 1994, vol. 50, # 18, p. 5515 - 5525
[3] Patent: US2004/92739, 2004, A1. Location in patent: Page 4
[4] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 2, p. 345 - 349
[5] Chemische Berichte, 1905, vol. 38, p. 3555
2-Amino-5-Methyl-Benzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from 2-Amino-5-Methyl-Benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-14 | 2-Amino-5-Methyl-Benzonitrile
5925-93-9
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-Amino-5-Methyl-Benzonitrile
5925-93-9
- $1.00
- 99%
- Career Henan Chemical Co
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