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CPNQ
- CAS No.
- 115687-05-3
- Chemical Name:
- CPNQ
- Synonyms
- B2;CPNQ;SIRT2-IN-8;SIRT2 Inhibitor, B2;Linazolamide intermediate B impurity 2;5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone;Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-;Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
- CBNumber:
- CB9972382
- Molecular Formula:
- C20H17ClN4O3
- Molecular Weight:
- 396.83
- MDL Number:
- MFCD02039810
- MOL File:
- 115687-05-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:28:46
| Product description | Number | Pack Size | Price |
| CPNQ ≥98% (HPLC), solid | C3118 | 5mg | $180 |
| CPNQ ≥98% (HPLC), solid | C3118 | 25mg | $719 |
| B2 Asreported | 254701 | 10mg | $403 |
| B2 Asreported | 254701 | 50mg | $1018 |
| B2 | TRC-B820015-5MG | 5mg | $918 |
| Melting point | 174-176°C |
|---|---|
| Boiling point | 645.5±55.0 °C(Predicted) |
| Density | 1.412±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: insoluble <2mg/mL |
| pka | 2.30±0.29(Predicted) |
| form | solid |
| color | brown |
| Water Solubility |
H2O: insoluble <2mg/mL DMSO: >5mg/mL |
| InChI | 1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2 |
| InChIKey | KLNPVNZJCWIQSK-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(Cl)cc3)c4cccnc14 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
CPNQ price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C3118 | CPNQ ≥98% (HPLC), solid | 115687-05-3 | 5mg | $180 | 2026-04-30 | Buy |
| Sigma-Aldrich | C3118 | CPNQ ≥98% (HPLC), solid | 115687-05-3 | 25mg | $719 | 2021-12-16 | Buy |
| Usbiological | 254701 | B2 Asreported | 115687-05-3 | 10mg | $403 | 2026-06-03 | Buy |
| Usbiological | 254701 | B2 Asreported | 115687-05-3 | 50mg | $1018 | 2026-06-03 | Buy |
| TRC | TRC-B820015-5MG | B2 | 115687-05-3 | 5mg | $918 | 2026-06-03 | Buy |
CPNQ Chemical Properties,Uses,Production
Uses
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.
Definition
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.
Biological Activity
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.
IC 50
SIRT2
CPNQ Preparation Products And Raw materials
Raw materials
Preparation Products
CPNQ Suppliers
Global( 55)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 272369594 | 2723695949@qq.com | China | 4995 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
Linazolamide intermediate B impurity 2
(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
SIRT2 Inhibitor, B2
Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-
Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
SIRT2-IN-8
CPNQ
B2
115687-05-3
