3-オキソシクロブタンカルボン酸
3-オキソシクロブタンカルボン酸 物理性質(zhì)
- 融點 :
- 69-70℃
- 沸點 :
- 296°C
- 比重(密度) :
- 1.431
- 閃點 :
- 147°C
- 貯蔵溫度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 外見 :
- 個體
- 酸解離定數(shù)(Pka):
- 4.35±0.20(Predicted)
- 色:
- オフホワイト
- 水溶解度 :
- 水にわずかに溶ける。
- InChI:
- InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
- InChIKey:
- IENOFRJPUPTEMI-UHFFFAOYSA-N
- SMILES:
- C1(C(O)=O)CC(=O)C1
- CAS データベース:
- 23761-23-1(CAS DataBase Reference)
3-オキソシクロブタンカルボン酸 価格
もっと(23)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01COBOS-7697 |
3-オキソシクロブタンカルボン酸
3-Oxocyclobutanecarboxylic acid |
23761-23-1 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01APOOR40464 |
3-Oxocyclobutane-1-carboxylic acid |
23761-23-1 |
5g |
￥5800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01APOOR40464 |
3-Oxocyclobutane-1-carboxylic acid |
23761-23-1 |
25g |
￥19200 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
O0392 |
3-オキソシクロブタンカルボン酸 >97.0%(GC)(T)
3-Oxocyclobutanecarboxylic Acid
>97.0%(GC)(T) |
23761-23-1 |
1g |
￥4600 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
O0392 |
3-オキソシクロブタンカルボン酸 >97.0%(GC)(T)
3-Oxocyclobutanecarboxylic Acid
>97.0%(GC)(T) |
23761-23-1 |
5g |
￥15200 |
2024-03-01 |
購入 |
3-オキソシクロブタンカルボン酸 化學(xué)特性,用途語,生産方法
外観
白色～うすい黃褐色、結(jié)晶性粉末～粉末
説明
3-Oxocyclobutanecarboxylic acid is an organic common intermediate compound used in pharmaceuticals, organic synthesis and organic light-emitting diode (OLED) intermediates. Abrocitinib, prepared from 3-Oxocyclobutanecarboxylic acid, is approved for the treatment of adult patients with atopic dermatitis (AD), as well as patients with refractory moderate to severe AD who have had limited or minimal response to other systemic medications.
化學(xué)的特性
White solid
使用
3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.
主な応用
3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.
製造方法
The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 3841, 1988
DOI: 10.1021/jo00251a033
3-オキソシクロブタンカルボン酸 上流と下流の製品情報
原材料
準(zhǔn)備製品
3,3-ジフルオロシクロブタンカルボン酸
5,8-ジオキサスピロ[3.4]オクタン-2-メタノール
3-ブロモシクロブタン-1-カルボン酸メチル
3-ブロモシクロブタノン
3-ヒドロキシシクロブタンカルボン酸エチル
Methyl cis-3-hydroxycyclobutanecarboxylate
Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI)
3-メチレンシクロブタンカルボン酸
3-Oxo-cyclobutanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester
isopropyl3-oxocyclobutane-1-carboxylate
Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)
3,3-difluorocyclobutane-1-carbonyl chloride
N-((3-chloropyrazin-2-yl)Methyl)-3-oxocyclobutanecarboxaMide
3-オキソシクロブタンカルボン酸 生産企業(yè)
Global( 558)Suppliers
3-オキソシクロブタンカルボン酸 スペクトルデータ(1HNMR)
23761-23-1(3-オキソシクロブタンカルボン酸)キーワード:
- 23761-23-1
- (3-oxocyclobutyl)carboxylic acid
- 3-Oxycyclobutanecarboxylic acid
- 3-Oxo-cyclobutanecarboxylic acid ,95%
- 3-Oxocyclobutanecarboxyli...
- 3-oxocyclobutanecarboxylic acid(SALTDATA: FREE)
- 3-Oxocyclobutane-1-carboxylic acid 98%
- IFLAB-BB F2124-0041
- CYCLOBUTANECARBOXYLIC ACID, 3-OXO-
- 3-Oxocyclobutanecarboxylic
- 1-Carboxy-3-oxocyclobutane
- 3-Oxocyclobutanecarboxylic acid 98%
- 3-Oxo-1-cyclobutanecarboxylic Acid
- 3-Oxocyclobutanecarboxylic Acid, 97+%
- 3-OxocyclobutanecarboxylicAcid>
- 3-OxocycL
- 3-oxo-cyclobutylkylcarboxylic acid
- CAS 23761-23-1 3-Oxocyclobutanecarboxylic acid
- Oxocyclobutanecarboxylic acid
- 3-Oxocyclobutanyl carboxylic acid
- 3-0xocyclobutanecarboxylic acid
- 3-Oxycyclobutanecarboxylic acid, 98%
- 3-oxocyclobutane-1,1-dicarboxylic acid
- 3-oxocyclobutane-1-carboxylic acid
- 3-OXO-CYCLOBUTANECARBOXYLIC ACID
- cyclobutanone-3-carboxylic acid
- 3-オキソシクロブタンカルボン酸
- (3-オキソシクロブチル)カルボン酸