WIKI4
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- CAS番號.
- 838818-26-1
- 化學名:
- 別名:
- 英語名:
- WIKI4
- 英語別名:
- WIKI;WIKI4;CS-1491;CS-2099;WIKI4 ，S7490;WIKI4 USP/EP/BP;WIKI4, 10 mM in DMSO;Tankyrase1/2 Inhibitor V, WIKI4;WIKI4, Wnt/ beta catenin inhibitor;PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4
- CBNumber:
- CB22731164
- 化學式:
- C29H23N5O3S
- 分子量:
- 521.59
- MOL File:
- 838818-26-1.mol
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WIKI4 物理性質(zhì)
- 沸點 :
- 783.1±70.0 °C(Predicted)
- 比重(密度) :
- 1.37±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- -20°C
- 溶解性:
- DMSO：可溶10mg/mL、透明（加溫）
- 酸解離定數(shù)(Pka):
- 1.70±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
- InChIKey:
- RNUXIZKXJOGYQP-UHFFFAOYSA-N
- SMILES:
- COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式會社(wako)
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W01TOC4855 |
WIKI4 |
838818-26-1 |
5mg |
￥44000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式會社(wako)
|
W01TOC4855 |
WIKI4 |
838818-26-1 |
25mg |
￥169000 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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SML0760 |
≥98% (HPLC)
WIKI4 ≥98% (HPLC) |
838818-26-1 |
5mg |
￥15920 |
2021-03-23 |
購入 |
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Sigma-Aldrich Japan
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SML0760 |
≥98% (HPLC)
WIKI4 ≥98% (HPLC) |
838818-26-1 |
25mg |
￥73900 |
2018-12-25 |
購入 |
WIKI4 化學特性,用途語,生産方法
説明
Tankyrases (TNKS) cleave NAD
+ to produce nicotinamide and ADP-
ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-
ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC
50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-
catenin pathway. WIKI4 inhibits the expression of β-
catenin target genes and cellular responses to Wnt/β-
catenin signaling in both cancer cell lines and embryonic stem cells.
使用
WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/-catenin signaling.
WIKI4 上流と下流の製品情報
原材料
準備製品
WIKI4 生産企業(yè)
Global( 100)Suppliers
838818-26-1()キーワード:
- 838818-26-1
- WIKI4
- 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
- WIKI
- 2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso
- 1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?-
- CS-2099
- CS-1491
- 2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
- WIKI4 USP/EP/BP
- PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4
- WIKI4, Wnt/ beta catenin inhibitor
- WIKI4, 10 mM in DMSO
- Tankyrase1/2 Inhibitor V, WIKI4
- WIKI4 ，S7490