(3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン 価格 もっと(9)

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入
富士フイルム和光純薬株式會社(wako)	W01LKTG4434	グリオトキシン Gliotoxin	67-99-2	1mg	￥28400	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01LKTG4434	グリオトキシン Gliotoxin	67-99-2	5mg	￥102200	2024-03-01	購入
Sigma-Aldrich Japan	G9893	グリオトキシン from Gliocladium fimbriatum Gliotoxin from Gliocladium fimbriatum	67-99-2	5mg	￥43000	2024-03-01	購入
Sigma-Aldrich Japan	G9893	グリオトキシン from Gliocladium fimbriatum Gliotoxin from Gliocladium fimbriatum	67-99-2	25mg	￥161000	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01TRCG410200	グリオトキシン Gliotoxin	67-99-2	1mg	￥59700	2024-03-01	購入

(3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン 化學(xué)特性,用途語,生産方法

化學(xué)的特性

White powder

使用

Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the re gulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent.

定義

ChEBI: A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.

危険性

Poison.

生物活性

Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I κ B α , an endogenous blocker of NF- κ B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC 50 values are 80 and 17 μ M respectively) and displays antitumor activity against breast cancer in vivo .

安全性プロファイル

Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes such as SOx and NOx.

純化方法

Purify gliotoxin by recrystallisation from MeOH. Its solubility in CHCl3 is 1%. The dibenzoyl derivative has m 202o (from CHCl3/MeOH). [Glister & Williams Nature 153 651 1944, Elvidge & Spring J Chem Soc Suppl 135 1949, Johnson et al. J Am Chem Soc 65 2005 1943, Bracken & Raistrick Biochem J 41 569 1947.]

(3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

(3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3970	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618791163155	18791163155@163.com	China	3397	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 13675144456	sean.lv@synzest.com	China	11438	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76

67-99-2((3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン)キーワード:

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• 67-99-2
• GLIOTOXIN
• GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM
• 2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE
• (3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl
• 10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox
• aspergillin
• s.n.12870
• gliotoxin from gliocladium fimbriatum
• GLIOTOXIN FROM GLIOCLADIUM VIRENS
• 10H-3,10a-Epidithiopyrazino1,2-aindole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-, (3R,5aS,6S,10aR)-
• (3R)-2-Methyl-3-(hydroxymethyl)-6β-hydroxy-3α,10aα-epidithio-1,2,3,4,5aβ,6,10,10a-octahydropyrazino[1,2-a]indole-1,4-dione
• 2,3,5aβ,6-Tetrahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-10H-3α,10aα-epidithiopyrazino[1,2-a]indole-1,4-dione
• S-82
• 6-Hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5ah-3,10A-epidithiopyrazino[1,2-A]indole-1,4-dione
• Aids086418
• Aids-086418
• Nsc102866
• (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
• Aspergillin, SN 12879, SN 12870
• Aspergillin solution
• Gliotoxin solution
• Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem
• Gliotoxin, 99%, from Gliocladium fimbriatum
• Gliotoxin, 98%, from Gliocladium fimbriatum
• GliotoxinQ: What is Gliotoxin Q: What is the CAS Number of Gliotoxin Q: What is the storage condition of Gliotoxin Q: What are the applications of Gliotoxin
• Gliotoxin in Acetonitrile
• Gliotoxin, NF-kappaB inhibitor
• Gliotoxin, Gladiocladium fimbriatum
• 2,3,5aβ,6-テトラヒドロ-6β-ヒドロキシ-3β-(ヒドロキシメチル)-2-メチル-10H-3α,10aα-エピジチオピラジノ[1,2-a]インドール-1,4-ジオン
• グリオトキシン
• アスペルギリン
• (3R)-2-メチル-3-(ヒドロキシメチル)-6β-ヒドロキシ-3α,10aα-エピジチオ-1,2,3,4,5aβ,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン
• 抗菌
• グリオトキシン 100ΜG/ML
• グリオトキシン FROM GLIOCLADIUM FIMBRIATUM
• (1R,7S,8S,11R)-7-ヒドロキシ-11-(ヒドロキシメチル)-15-メチル-12,13-ジチア-9,15-ジアザテトラシクロ[9.2.2.01,9.03,8]ペンタデカ-3,5-ジエン-10,14-ジオン
• (3R,5aS,6S,10aR)-2,3,5a,6-テトラヒドロ-6-ヒドロキシ-3-(ヒドロキシメチル)-2-メチル-10H-3α,10a-エピジチオピラジノ[1,2-a]インドール-1,4-ジオン
• (3R,5aS,6S,10aR)-2-メチル-3-(ヒドロキシメチル)-6-ヒドロキシ-3,10a-エピジチオ-1,2,3,4,5a,6,10,10a-オクタヒドロピラジノ[1,2-a]インドール-1,4-ジオン
• 免疫抑制薬
• 生理活性因子