ノルマルパラフィン 化學(xué)特性,用途語,生産方法
解説
ノルマルパラフィンは，パラフィン系炭化水素の一つ。融解潛熱や生分解性が高く、空調(diào)システムの蓄熱材や界面活性剤の原料として利用される。
小學(xué)館 デジタル大辭泉について 情報(bào) | 凡例
化學(xué)的特性
Light mineral oil is a transparent, colorless liquid, without
fluorescence in daylight. It is practically tasteless and odorless
when cold, and has a faint odor when heated. The USP32–NF27
specifies that light mineral oil may contain a suitable stabilizer.
調(diào)製方法
Light mineral oil is obtained by the distillation of petroleum. A
suitable stabilizer may be added to the oil.
応用例（製薬）
Light mineral oil is used in applications similar to those of mineral
oil.It is used primarily as an excipient in topical pharmaceutical
formulations where its emollient properties are exploited in
ointment bases. It is also used in ophthalmic
formulations. Light mineral oil is additionally used in oil-inwater
and polyethlylene glycol/glycerol emulsions; as a solvent
and lubricant in capsules and tablets; as a solvent and penetration
enhancer in transdermal preparations;and as the oily medium
used in the microencapsulation of many drugs.
Light mineral oil is also used in cosmetics and certain food
products.
安全性
Light mineral oil is used in applications similar to those of mineral
oil. Mineral oil is considered safe by the FDA for direct use in foods.
However, oral ingestion of large doses of light mineral oil or chronic
consumption may be harmful. Chronic use may impair appetite and
interfere with the absorption of fat-soluble vitamins. It is absorbed
to some extent when emulsified, leading to granulomatous
reactions. Oral and intranasal use of mineral oil or products
containing mineral oil by infants or children is not recommended
because of the possible danger of causing lipoid pneumonia.
See Mineral Oil for further information.
貯蔵
Light mineral oil undergoes oxidation when exposed to heat and
light. Oxidation begins with the formation of peroxides, exhibiting
an ‘induction period’. Under typical storage conditions, the
induction period may take months or years. However, once a trace
of peroxide is formed, further oxidation is autocatalytic and
proceeds very rapidly. Oxidation results in the formation of
aldehydes and organic acids, which impart taste and odor. The USP32–NF27 permits the addition of suitable stabilizers to retard
oxidation, butylated hydroxyanisole, butylated hydroxytoluene,
and alpha tocopherol being the most commonly used antioxidants.
Light mineral oil may be sterilized by dry heat.
Light mineral oil should be stored in an airtight container in a
cool, dry place and protected from light.
不和合性
Incompatible with strong oxidizing agents.
規(guī)制狀況(Regulatory Status)
GRAS listed. Accepted in the UK for use in certain food
applications. Light mineral oil is included in the FDA Inactive
Ingredients Database (ophthalmic preparations; oral capsules and
tablets; otic, rectal, topical, and transdermal preparations). Included
in nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
ノルマルパラフィン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品