(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole 価格

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(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole 化學(xué)特性,用途語,生産方法

合成

Suspension of 2- bromo- 4- nitroimidazole (100 g), 2- methyl- 2- oxiranylmethyl (S)- 4- nitrobenzenesulfonate (142.4 g), potassium carbonate (93.6 g), caesium fluoride (15.8 g) and dimethylformamide (420 ml) was stirred at 35- 40°C for 26 hours. The reaction mixture was poured into water (1.2 litres) and then extracted twice with ethyl acetate (1 litre). The ethyl acetate layers were combined after being washed twice with water (1.2 liters), washed with an aqueous solution (800 ml) saturated with sodium chloride, then dried over anhydrous magnesium sulfate. After being filtrated under reduced pressure, the filtrate was concentrated under a reduced pressure. The thus obtained residue was purified by use of a silica gel column chromatography (eluent: n-hexane/ ethyl acetate = 1/1), there was obtained (R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole (110.9 g, yield: 81%) as a yellow powdery product.

(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole 上流と下流の製品情報

原材料

準備製品

(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	zwchem@163.com	China	571	61
Changzhou Yourui Pharmaceutical Technology Co., Ltd	18168818882 15961169601;	877458914@qq.com	China	8724	58
Hubei Rhema Reference Materials Technology Co., Ltd.	15787879035 15787875101	ydw9035@rmastandards.com	China	9979	58
Henan Inokai New Materials Co., Ltd	15090072163	3921118937@qq.com	China	2481	58
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.	0714-3999001 17771081808	2654977911@qq.com	China	9998	58

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• 681484-60-6
• DE-8
• 2-bromo-1-[[(2R)-2-methyloxiran-2-yl]methyl]-4-nitroimidazole
• 1H-Imidazole, 2-bromo-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro-
• (R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole
• Delamanid Impurity 28