JQ-1 価格 もっと(10)

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01COBQH-8485	(+)-Jq-1	1268524-70-4	250mg	￥52500	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01COBQH-8485	(+)-Jq-1	1268524-70-4	100mg	￥63000	2023-06-01	購(gòu)入
Sigma-Aldrich Japan	SML1524	≥98% (HPLC) (+)-JQ1 ≥98% (HPLC)	1268524-70-4	5mg	￥39200	2024-03-01	購(gòu)入
Sigma-Aldrich Japan	SML1524	≥98% (HPLC) (+)-JQ1 ≥98% (HPLC)	1268524-70-4	25mg	￥119000	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01TRCT117580	(S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate	1268524-70-4	5mg	￥18300	2024-03-01	購(gòu)入

JQ-1 化學(xué)特性,用途語(yǔ),生産方法

使用

BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.

一般的な説明

JQ1 is a member of the triazolo-diazepine compound family, which functions as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.

Biochem/physiol Actions

(+)-JQ1 is a high affinity, potent and selective inhibitor of BET bromodomain proteins, including BRD2, BRD3, BRD4 and BRDT. (+)-JQ1 (also known as SGCBD01), the active enantiomer of (+/-)-JQ1, inhibits Brd4 (bromodomain-containing 4), which forms complexes with chromatin via two tandem bromodomains (BD1 and BD2) that bind to acetylated lysine residues in histones and Brd4 association with acetylated chromatin is believed to regulate the recruitment of elongation factor b and additional transcription factors to specific promoter regions. The nuclear protein in testis (NUT) gene is known to form fusions with Brd4 that create a potent oncogene, leading to rare, but highly lethal tumors referred to as NUT midline carcinomas (NMC). (+)-JQ1 inhibits recruitment and binding of Brd4 to TNFa and E-selectin promoter elements, and accelerates recovery time in FRAP (fluorescence recovery after photobleaching) assays using GFP-Brd4. Thus (+)-JQ1 is a useful tool to study the role of Brd4 in transcriptional initiation.For characterization details of (+)-JQ1, please visit the JQ-1 probe summary on the Structural Genomics Consortium (SGC) website.(-)-JQ1 is the negative control for the active enantiomer, (+)-JQ1. (-)-JQ1 is available from Sigma. To learn more about and purchase (-)-JQ1, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

JQ-1 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

JQ-1 生産企業(yè)

名前	電話(huà)番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2994	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.	0431-80514535 13634302652	Extension@chemextension.com	CHINA	967	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58

1268524-70-4(JQ-1)キーワード:

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• 1268524-70-4
• (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
• (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thienol[3,2-f][1,2,4]troazolo[4,3-a][1,4]diazepin-6-yl)acetate[(+)-6]
• (+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
• (+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS：
• BroModoMain Inhibitor, (+)-JQ1
• 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, 1,1-diMethylethyl ester, (6S)-
• (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (+)-JQ-1
• (6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium
• jq01
• (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3-a][1
• (+)-JQ1, >=99%
• CS-799
• (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
• JQ-1;JQ 1;JQ1;+JQ 1;+JQ-1;+JQ1
• S-JQ1
• (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diaz
• 3,9-trimethyl-6
• (S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4
• (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate USP/EP/BP
• Bet bromodomain inhibitors
• (S)-tert-butyl 2-(4-(4-chlorophenyl)-2
• 4]diazepin-6-yl)acetate
• 9-triMethyl-6H-thieno[3
• tert-butyl 2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
• (6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-t...
• (+)-JQ-1
• (+)JQ1
• JQ1 compound
• Bromodomain Inhibitor
• Ceftobiprole Impurity 23
• (6S)-2,3,9-トリメチル-4-(4-クロロフェニル)-1-チア-5,7,8,9a-テトラアザ-6H-シクロペンタ[e]アズレン-6β-酢酸t(yī)ert-ブチル
• (6S)-4-(4-クロロフェニル)-2,3,9-トリメチル-6H-チエノ[3,2-f][1,2,4]トリアゾロ[4,3-a][1,4]ジアゼピン-6-酢酸t(yī)ert-ブチル
• (6S)-6,9a-ジヒドロ-2,3,9-トリメチル-4-(4-クロロフェニル)-5,7,8,9a-テトラアザアズレノ[4,5-b]チオフェン-6-酢酸t(yī)ert-ブチル
• tert-ブチル 2-[(9S)-7-(4-クロロフェニル)-4,5,13-トリメチル-3-チア-1,8,11,12-テトラアザトリシクロ[8.3.0.02,6]トリデカ-2(6),4,7,10,12-ペンタエン-9-イル]アセタート
• (6S)-2,3,9-トリメチル-4-(4-クロロフェニル)-1-チア-5,7,8,9a-テトラアザ-6H-シクロペンタ[e]アズレン-6-酢酸t(yī)ert-ブチル
• JQ-1
• 4-(4-クロロフェニル)-2,3,9-トリメチル-6H-チエノ[3,2-f][1,2,4]トリアゾロ[4,3-a][1,4]ジアゼピン-6β-酢酸t(yī)ert-ブチル