レンボレキサント 価格

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入

レンボレキサント 化學(xué)特性,用途語(yǔ),生産方法

効能

催眠薬, オレキシン受容體拮抗薬

説明

Lemborexant is a newer orexin receptor antagonist which is submitted to US FDA for review as new drug application for the treatment of insomnia after completing two key Phase 3 studies of lemborexant – SUNRISE 1 (Study 304) and SUNRISE 2 (Study 303).

化學(xué)的特性

Lemborexant is a white to off-white powder that is practically insoluble in water.

使用

Lemborexant is a novel orexin receptor antagonist and is used in the treatment of insomnia, characterised by difficulties with sleep onset or sleep maintenance. Orexins are neuropeptides involved in regulating sleep and arousal by promoting wakefulness. Lemborexant blocks the binding of orexins A and B to their receptors 1 and 2 thereby reducing wakefulness and promoting sleep. Suvorexant is the other orexin receptor antagonist marketed in Australia for insomnia.

薬物動(dòng)態(tài)學(xué)

合成

Synthesis route of Lemborexant

薬物相互作用

Lemborexant is metabolized by CYP3A4 and is susceptible to interactions with medications such as amiodarone, amlodipine, carbamazepine, clarithromycin, diltiazem, fluoxetine and phenytoin. Lemborexant may affect other medications metabolised by CYP2B6, such as bupropion and methadone. Alcohol should be avoided: a single dose of alcohol can increase lemborexant concentrations up to 70%.

Mode of action

The mechanism of action of lemborexant in the treatment of insomnia is Blocks the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R, presumed to suppress wake drive.

參考文獻(xiàn)

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212028s000lbl.pdf
https://www.smchealth.org/sites/main/files/file-attachments/dayvigo_for_publish.pdf1592332002
https://www.superiorhealthplan.com/content/dam/centene/Superior/policies/pharmacy-policies/Lemborexant%20(Dayvigo)%20(CP.PMN.233)%20(PDF).pdf

レンボレキサント 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

レンボレキサント 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3703	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	529	58
Xi an Biohorlden Industry Trade Co Ltd	+86-18829283179 +86-13636819721	sales@horlden.com	China	334	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
AFINE CHEMICALS LIMITED	+86-571-85134551	info@afinechem.com	China	15083	58

1369764-02-2(レンボレキサント)キーワード:

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• 1369764-02-2
• E 2006
• Lemborexant
• lemborexant,E2006
• (1R,2S)-2-[(2,4-DIMETHYLPYRIMIDIN-5-YL)OXYMETHYL]-2-(3-FLUOROPHENYL)-N-(5-FLUOROPYRIDIN-2-YL)CYCLOPROPANE-1-CARBOXAMIDE
• lemborexant / E-2006, CID 56944144
• E-2006 Lemborexant
• 2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide
• CS-2189
• Dayvigo.
• E-2006; E 2006; E2006; LEMBOREXANT; DAYVIGO.
• Cyclopropanecarboxamide, 2-[[(2,4-dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)-, (1R,2S)-
• Lemborexant USP/EP/BP
• Lemborexant API
• labradon
• (1S,2R)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-1-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide
• Lemborexant Impurity 1
• (1R,2S)-2-[[(2,4-dimethyl-5-pyrimidine)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridyl)cyclopropaneformamide (Leborethen)
• (1R,2S)-2-[[(2,4-Dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)cyclopropanecarboxamide
• Lemborexan
• レンボレキサント
• レンボレキサント (JAN)
• (1R,2S)-2-{[(2,4-ジメチルピリミジン-5-イル)オキシ]メチル}-2-(3-フルオロフェニル)-N-(5-フルオロピリジン-2-イル)シクロプロパン-1-カルボキサミド
• (1R,2S)-N-(5-フルオロピリジン-2-イル)-2α-(3-フルオロフェニル)-2-(2,4-ジメチルピリミジン-5-イルオキシメチル)シクロプロパン-1β-カルボアミド
• (1R)-N-(5-フルオロ-2-ピリジニル)-2β-(2,4-ジメチル-5-ピリミジニルオキシメチル)-2-(3-フルオロフェニル)シクロプロパン-1β-カルボアミド
• デエビゴ錠