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グラブリジン

グラブリジン 化學(xué)構(gòu)造式
59870-68-7
CAS番號(hào).
59870-68-7
化學(xué)名:
グラブリジン
別名:
グラブリジン;4-(8,8-ジメチル-3,4-ジヒドロ-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン-3β-イル)-1,3-ベンゼンジオール;4-[(3R)-8,8-ジメチル-2H,3H,4H,8H-ピラノ[2,3-f]クロメン-3-イル]ベンゼン-1,3-ジオール;4-[[(R)-3,4-ジヒドロ-8,8-ジメチル-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン]-3-イル]-1,3-ベンゼンジオール;4-[[(R)-3,4-ジヒドロ-8,8-ジメチル-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン]-3β-イル]-1,3-ベンゼンジオール
英語名:
Glabridin
英語別名:
glabridine;Q-100692;GLABRIDIN;LGB-GD 90;LGB-GD 40;KB-289522;LS-176045;Aids096010;Aids-096010;Glabridin-RM
CBNumber:
CB7670448
化學(xué)式:
C20H20O4
分子量:
324.37
MOL File:
59870-68-7.mol
MSDS File:
SDS

グラブリジン 物理性質(zhì)

融點(diǎn) :
154~155℃
沸點(diǎn) :
518.6±50.0 °C(Predicted)
比重(密度) :
1.257±0.06 g/cm3(Predicted)
閃點(diǎn) :
267℃
貯蔵溫度 :
room temp
溶解性:
DMSO:可溶5mg/mL、透明(加溫)
外見 :
酸解離定數(shù)(Pka):
9.66±0.40(Predicted)
色:
白から薄茶色
BRN :
7141956
安定性::
吸濕性
化粧品成分の機(jī)能:
BLEACHING
InChI:
InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey:
PMPYOYXFIHXBJI-ZDUSSCGKSA-N
SMILES:
C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1
LogP:
4.260 (est)
CAS データベース:
59870-68-7(CAS DataBase Reference)

安全性情報(bào)

Sフレーズ  24/25
WGK Germany  3
HSコード  29329990
ストレージクラス 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral

グラブリジン 価格 もっと(10)

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會(huì)社(wako) W01CHDASB-00007234 グラブリジン
Glabridin
59870-68-7 5mg ¥91800 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01CHDASB-00007234 グラブリジン
Glabridin
59870-68-7 10mg ¥145800 2024-03-01 購入
関東化學(xué)株式會(huì)社(KANTO) 49063-80 グラブリジン
Glabridin
59870-68-7 10mg ¥92000 2024-07-01 購入
Sigma-Aldrich Japan G9548 グラブリジン ≥98% (HPLC), powder
Glabridin ≥98% (HPLC), powder
59870-68-7 5mg ¥20900 2024-03-01 購入
Sigma-Aldrich Japan 53633 グラブリジン analytical standard
Glabridin analytical standard
59870-68-7 10mg ¥155000 2023-06-01 購入

グラブリジン 化學(xué)特性,用途語,生産方法

外観

白色~うすい黃褐色, 結(jié)晶~粉末

定義

本品は、次の化學(xué)式で表される有機(jī)化合物である。

溶解性

エタノールに溶け、水にほとんど溶けない。

化粧品の成分用途

皮膚ブリーチ剤

化學(xué)的特性

White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc.

使用

Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.

定義

ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

利點(diǎn)

Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant.

Mode of action

Glabridin[59870-68-7] is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolic process of the body, to avoid oxidative damage to oxidation-sensitive biological macromolecules (low-density lipoprotein LDL, DNA) and the cell wall, etc. by free radical oxidation. Thus, it can prevent certain pathological changes related to free radical oxidation, such as atherosclerosis, and cellular aging. In addition, Glabridin has some hypolipidemic and hypotensive effects.

參考文獻(xiàn)

Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);

グラブリジン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


グラブリジン 生産企業(yè)

Global( 665)Suppliers
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グラブリジン  スペクトルデータ(1HNMR)


59870-68-7(グラブリジン)キーワード:


  • 59870-68-7
  • (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol
  • 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol
  • Glabridin, >=98%
  • Glabridin/Propylene Glycol
  • 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
  • GLABRIDIN
  • 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol
  • 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-B:4,3-B']dipyran-3-yl)-benzene-1,3-diol
  • Aids096010
  • Aids-096010
  • GLABRIDIN(RG)
  • GLABRIDIN (GLYCYRRHIZA GLABRA ROOT EXTRACT)
  • 4-(8,8-DiMethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chroMen-3-yl)-benzene-1,3-diol
  • 2H,8H-Benzo[1,2-b:3,4-b']dipyran,1,3-benzenediolderiv
  • Liquorice flavonoids
  • Glabridin, froM Liquorice root
  • Glabridin/OIL SOLUBLE LICORICE(GLYCYRRHIZA) EXTRACT
  • professional manufacturer Glabridin 59870-68-7
  • 98% Glabridin 59870-68-7 Light-yellow powder
  • Light liquorice set
  • LGB-GD 90
  • LGB-GD 40
  • Soluble GLABRIDIN, Liposomal GLABRIDIN, GLABRIDIN NanoEmulsion, NanoActive GLABRIDIN
  • BioaActive Glabridin
  • Nanoactive Glabridin
  • Soluble Glabridin
  • 1,3-Benzenediol,4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-
  • Glabridin, 98%, from Liquorice root
  • KB-289522
  • LS-176045
  • グラブリジン
  • 4-(8,8-ジメチル-3,4-ジヒドロ-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン-3β-イル)-1,3-ベンゼンジオール
  • 4-[(3R)-8,8-ジメチル-2H,3H,4H,8H-ピラノ[2,3-f]クロメン-3-イル]ベンゼン-1,3-ジオール
  • 4-[[(R)-3,4-ジヒドロ-8,8-ジメチル-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン]-3-イル]-1,3-ベンゼンジオール
  • 4-[[(R)-3,4-ジヒドロ-8,8-ジメチル-2H,8H-ベンゾ[1,2-b:3,4-b′]ジピラン]-3β-イル]-1,3-ベンゼンジオール
  • 生物學(xué)?臨床用標(biāo)準(zhǔn)物質(zhì)
  • 一般醫(yī)薬品
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