酢酸マフェニド
酢酸マフェニド 物理性質(zhì)
- 融點(diǎn) :
- 151-152°C
- 貯蔵溫度 :
- Inert atmosphere,2-8°C
- 溶解性:
- DMSO：可溶1mg/mL
- 外見(jiàn) :
- 個(gè)體
- 色:
- 白い
- InChI:
- InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)
- InChIKey:
- UILOTUUZKGTYFQ-UHFFFAOYSA-N
- SMILES:
- C1(=CC=C(CN)C=C1)S(=O)(=O)N.C(=O)(O)C
- CAS データベース:
- 13009-99-9(CAS DataBase Reference)
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| WGK Germany |
3 |
|
|
| 國(guó)連危険物分類 |
IRRITANT |
|
|
| HSコード |
2935904000 |
|
|
| ストレージクラス |
11 - Combustible Solids |
|
|
| 毒性 |
LD50 in rats, mice (mg/kg): 2040, 1580 i.v. (Skulan, Hoppe) |
|
|
| 絵表示（GHS） |
|
| 注意喚起語(yǔ) |
警告 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語(yǔ) |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強(qiáng)い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
吸入すると有害 |
急性毒性、吸入 |
4 |
警告 |
|
P261, P271, P304+P340, P312 |
| H335 |
呼吸器への刺激のおそれ |
特定標(biāo)的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P280 |
保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。 |
| P305+P351+P338 |
眼に入った場(chǎng)合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場(chǎng)合は外す こと。その後も洗浄を続けること。 |
|
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01TRCM110200 |
酢酸マフェニド
Mafenide Acetate |
13009-99-9 |
50mg |
￥37500 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQJ-2500 |
酢酸4-(アミノメチル)ベンゼンスルホンアミド
4-(Aminomethyl)benzenesulfonamide acetate |
13009-99-9 |
5g |
￥10000 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQJ-2500 |
酢酸4-(アミノメチル)ベンゼンスルホンアミド
4-(Aminomethyl)benzenesulfonamide acetate |
13009-99-9 |
1g |
￥10000 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQJ-2500 |
4-(Aminomethyl)benzenesulfonamide acetate |
13009-99-9 |
10g |
￥27000 |
2023-06-01 |
購(gòu)入 |
|
Sigma-Aldrich Japan
|
1373008 |
United States Pharmacopeia (USP) Reference Standard
Mafenide acetate United States Pharmacopeia (USP) Reference Standard |
13009-99-9 |
200mg |
￥57500 |
2024-03-01 |
購(gòu)入 |
酢酸マフェニド 化學(xué)特性,用途語(yǔ),生産方法
効能
外用抗菌薬
説明
Mafenide Acetate, also known sulfamylon acetate, is a topical sulphonamide antimicrobial agent with activity against a wide range of microorganisms commonly associated with burn wound infections, including Pseudomonas aeruginosa and Staphylococcus aureus. It is primarily used for the prevention and treatment of burn wound infections. As a carbonic anhydrase inhibitor, sulfamylon acetate may cause metabolic acidosis and peripheral vasodilation. Therefore, its concomitant use with hyperbaric oxygen therapy should be carefully assessed. In burn patients requiring hyperbaric oxygen therapy, silver sulfadiazine may be considered as an alternative topical antimicrobial agent.
化學(xué)的特性
Mafenide acetate, USP is a white, crystalline powder which is freely soluble in water.
一般的な説明
4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds.
This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.
Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.
酢酸マフェニド 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
酢酸マフェニド 生産企業(yè)
Global( 268)Suppliers
13009-99-9(酢酸マフェニド)キーワード:
- 13009-99-9
- 4-aminomethylbenzenesulfonamide acetate salt
- 4-(aminomethyl)benzenesulfonamidemonoacetate
- 4-(aminomethyl)benzenesulfonimideacetate
- Mafenide Acetate (400 mg)
- Methotroxate Disodium
- α-AMINO-P-TOLUENSULFONAMIDEMONOACETATE
- A-AMINO-P-TOLUENSULFONAMIDEMONOACETATE
- Mefamide
- Sulfamylon Acetate
- α-Amino-p-toluenesulfonamide Acetate
- a-Amino-p-toluenesulfonamide Acetate
- Mafenide Acetate (200 mg)
- Mafenide acetate, >=99%
- 4-HOMOSULFANILAMIDE ACETATE
- 4-HOMOSULFANILAMIDE ACETATE SALT
- 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE
- 4-(AMINOMETHYL)BENZENESULFONAMIDE ACETATE
- ALPHA-AMINO-P-TOLUENSULFONAMIDE MONOACETATE
- P-(AMINOMETHYL) BENZENESULFONAMIDE ACETATE
- P-AMINOMETHYLBENZENESULFONAMIDE ACETATE SALT
- alpha-aminotoluene-4-sulphonamide monoacetate
- Mafenidine Acetate
- MAFENIDE ACETATE, 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE
- 4-(aminomethyl)-benzenesulfonamidmonoacetate
- alpha-amino-p-toluenesulfonamidmonoacetate
- mafatate
- maphenideacetate
- MARFANIL
- MARFANIL ACETATE SALT
- MAFENAMIDE ACETATE
- 4-(アミノメチル)ベンゼンスルホンアミド·酢酸
- 酢酸マフェニド
- 4-(アミノメチル)ベンゼンスルホンアミド酢酸塩
- 酢酸4-(アミノメチル)ベンゼンスルホンアミド
- 酢酸マフェニド (JAN)
- 4-(アミノメチル)ベンゼンスルホンアミド?酢酸