スロペネム 化學(xué)特性,用途語(yǔ),生産方法
効能
抗菌薬
説明
Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme.
使用
Sulopenem is a β-Lactamase inhibitor which is used in treatment of microbial infections. It is an important reagent for many drugs synthesized against bacterial infections.
作用機(jī)序
Sulopenem is one of the penems and, as such, interacts with penicillin-binding proteins (PBPs). From in vitro studies, sulopenem has shown a high affinity for PBP1a, 1b, 2, and 3 in E. coli.
薬物動(dòng)態(tài)學(xué)
When 1 g of CP-65,207 [containing 46.3% of S-isomer (sulopenem)
and 53.7% of R-isomer] was administered by 10-minute intravenous
infusions, the peak concentration of sulopenem in serum was 36.0 mg/
ml, its half-life was 52.8 minutes, and the area under the serum
concentration-versus-time curve (AUC) from 0 to 8 hours was
21.0 mg/ml per hour.
スロペネム 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品